Robert D Salazar1, Asher M Le1, Sandy Neargarder2, Alice Cronin-Golomb3. 1. Department of Psychological and Brain Sciences, Boston University, USA. 2. Department of Psychological and Brain Sciences, Boston University, USA; Department of Psychology, Bridgewater State University, USA. 3. Department of Psychological and Brain Sciences, Boston University, USA. Electronic address: alicecg@bu.edu.
Abstract
OBJECTIVE: Anxiety is commonly endorsed in Parkinson's disease (PD) and significantly affects quality of life. The Beck Anxiety Inventory (BAI) is often used but contains items that overlap with common PD motor symptoms (e.g., "hands trembling"). Because of these overlapping items, we hypothesized that PD motor symptoms would significantly affect BAI scores. METHODS: One hundred non-demented individuals with PD and 74 healthy control participants completed the BAI. PD motor symptoms were assessed by the Unified Parkinson's Disease Rating Scale (UPDRS). Factor analysis of the BAI assessed for a PD motor factor, and further analyses assessed how this factor affected BAI scores. RESULTS: BAI scores were significantly higher for PD than NC. A five-item PD motor factor correlated with UPDRS observer-rated motor severity and mediated the PD-control difference on BAI total scores. An interaction occurred, whereby removal of the PD motor factor resulted in a significant reduction in BAI scores for PD relative to NC. The correlation between the BAI and UPDRS significantly declined when controlling for the PD motor factor. CONCLUSIONS: The results indicate that commonly endorsed BAI items may reflect motor symptoms such as tremor instead of, or in addition to, genuine mood symptoms. These findings highlight the importance of considering motor symptoms in the assessment of anxiety in PD and point to the need for selecting anxiety measures that are less subject to contamination by the motor effects of movement disorders.
OBJECTIVE:Anxiety is commonly endorsed in Parkinson's disease (PD) and significantly affects quality of life. The Beck Anxiety Inventory (BAI) is often used but contains items that overlap with common PD motor symptoms (e.g., "hands trembling"). Because of these overlapping items, we hypothesized that PD motor symptoms would significantly affect BAI scores. METHODS: One hundred non-demented individuals with PD and 74 healthy control participants completed the BAI. PD motor symptoms were assessed by the Unified Parkinson's Disease Rating Scale (UPDRS). Factor analysis of the BAI assessed for a PD motor factor, and further analyses assessed how this factor affected BAI scores. RESULTS: BAI scores were significantly higher for PD than NC. A five-item PD motor factor correlated with UPDRS observer-rated motor severity and mediated the PD-control difference on BAI total scores. An interaction occurred, whereby removal of the PD motor factor resulted in a significant reduction in BAI scores for PD relative to NC. The correlation between the BAI and UPDRS significantly declined when controlling for the PD motor factor. CONCLUSIONS: The results indicate that commonly endorsed BAI items may reflect motor symptoms such as tremor instead of, or in addition to, genuine mood symptoms. These findings highlight the importance of considering motor symptoms in the assessment of anxiety in PD and point to the need for selecting anxiety measures that are less subject to contamination by the motor effects of movement disorders.
Authors: A F G Leentjens; K Dujardin; L Marsh; P Martinez-Martin; I H Richard; S E Starkstein Journal: Parkinsonism Relat Disord Date: 2012-07-06 Impact factor: 4.891
Authors: Albert F G Leentjens; Kathy Dujardin; Gregory M Pontone; Sergio E Starkstein; Daniel Weintraub; Pablo Martinez-Martin Journal: Mov Disord Date: 2014-05-23 Impact factor: 10.338
Authors: Gilberto Levy; Elan D Louis; Lucien Cote; Mario Perez; Helen Mejia-Santana; Howard Andrews; Juliette Harris; Cheryl Waters; Blair Ford; Steven Frucht; Stanley Fahn; Karen Marder Journal: Arch Neurol Date: 2005-03
Authors: Sonja Rutten; Ires Ghielen; Chris Vriend; Adriaan W Hoogendoorn; Henk W Berendse; Albert F G Leentjens; Ysbrand D van der Werf; Jan H Smit; Odile A van den Heuvel Journal: Parkinsonism Relat Disord Date: 2014-12-10 Impact factor: 4.891
Authors: P Martinez-Martin; J M Rojo-Abuin; K Dujardin; G M Pontone; D Weintraub; M J Forjaz; S Starkstein; A F G Leentjens Journal: Eur J Neurol Date: 2013-04-14 Impact factor: 6.089
Authors: Maria João Forjaz; Pablo Martinez-Martin; Kathy Dujardin; Laura Marsh; Irene H Richard; Sergio E Starkstein; Albert F G Leentjens Journal: J Psychosom Res Date: 2013-03-19 Impact factor: 3.006
Authors: Zuzana Kosutzka; Alice Kusnirova; Michal Hajduk; Igor Straka; Michal Minar; Peter Valkovic Journal: Front Neurol Date: 2019-09-24 Impact factor: 4.003
Authors: Stephanie Cernera; Robert S Eisinger; Joshua K Wong; Kwo Wei David Ho; Janine Lobo Lopes; Kevin To; Samuel Carbunaru; Adolfo Ramirez-Zamora; Leonardo Almeida; Kelly D Foote; Michael S Okun; Aysegul Gunduz Journal: NPJ Parkinsons Dis Date: 2020-07-06