| Literature DB >> 27125191 |
Ganesh Narayanan1, Varadraj N Vernekar1, Emmanuel L Kuyinu1, Cato T Laurencin2.
Abstract
Regenerative engineering converges tissue engineering, advanced materials science, stem cell science, and developmental biology to regenerate complex tissues such as whole limbs. Regenerative engineering scaffolds provide mechanical support and nanoscale control over architecture, topography, and biochemical cues to influence cellular outcome. In this regard, poly (lactic acid) (PLA)-based biomaterials may be considered as a gold standard for many orthopaedic regenerative engineering applications because of their versatility in fabrication, biodegradability, and compatibility with biomolecules and cells. Here we discuss recent developments in PLA-based biomaterials with respect to processability and current applications in the clinical and research settings for bone, ligament, meniscus, and cartilage regeneration.Entities:
Keywords: Bone; Cartillage; Growth factors; Ligament; Meniscus regeneration; Poly (lactic acid); Regenerative Engineering; Small molecules
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Year: 2016 PMID： 27125191 PMCID： PMC5482531 DOI： 10.1016/j.addr.2016.04.015
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470