Literature DB >> 27122777

The Role of the Renin-Angiotensin System in Amyloid Metabolism of Alzheimer's Disease.

Chao-Liang Chou1, Hung-I Yeh2.   

Abstract

UNLABELLED: The etiology of Alzheimer's disease (AD) remains unclear. Epidemiologic studies suggest hypertension plays a contributing role to AD. Recently, several experimental and observational studies showed interaction between the renin-angiotensin system and amyloid-β, a key pathologic feature of AD, with diverse results. This article reviews molecular, genetic, experimental and clinical data to clarify the impact on an AD patient with angiotensin converting enzyme inhibitor and angiotensin II receptor blocker therapy, with some guidance for the direction of possible future research. KEY WORDS: Alzheimer's disease; Amyloid-β; Renin angiotensin system.

Entities:  

Year:  2014        PMID： 27122777      PMCID： PMC4805016     

Source DB:  PubMed          Journal:  Acta Cardiol Sin        ISSN： 1011-6842            Impact factor:   2.672


  43 in total

1.  Angiotensin converting enzyme density is increased in temporal cortex from patients with Alzheimer's disease.

Authors:  N M Barnes; C H Cheng; B Costall; R J Naylor; T J Williams; C M Wischik
Journal:  Eur J Pharmacol       Date:  1991-08-06       Impact factor: 4.432

2.  Angiotensin-receptor blockers and risk of Alzheimer's disease in hypertension population--a nationwide cohort study.

Authors:  Chien-Yi Hsu; Chin-Chou Huang; Wan-Leong Chan; Po-Hsun Huang; Chia-Hung Chiang; Tzeng-Ji Chen; Chia-Min Chung; Shing-Jong Lin; Jaw-Wen Chen; Hsin-Bang Leu
Journal:  Circ J       Date:  2012-11-10       Impact factor: 2.993

3.  Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.

Authors:  G G Glenner; C W Wong
Journal:  Biochem Biophys Res Commun       Date:  1984-05-16       Impact factor: 3.575

Review 4.  Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport.

Authors:  T A Bayer; O Wirths; K Majtényi; T Hartmann; G Multhaup; K Beyreuther; C Czech
Journal:  Brain Pathol       Date:  2001-01       Impact factor: 6.508

5.  The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial.

Authors:  Hans Lithell; Lennart Hansson; Ingmar Skoog; Dag Elmfeldt; Albert Hofman; Bertil Olofsson; Peter Trenkwalder; Alberto Zanchetti
Journal:  J Hypertens       Date:  2003-05       Impact factor: 4.844

Review 6.  Hypertension, hypertension-clustering factors and Alzheimer's disease.

Authors:  Ingmar Skoog; Deborah Gustafson
Journal:  Neurol Res       Date:  2003-09       Impact factor: 2.448

7.  Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis.

Authors:  Tricia A Thornton-Wells; Jason H Moore; Eden R Martin; Margaret A Pericak-Vance; Jonathan L Haines
Journal:  Genet Epidemiol       Date:  2008-04       Impact factor: 2.135

8.  Dementia is the major cause of functional dependence in the elderly: 3-year follow-up data from a population-based study.

Authors:  H Agüero-Torres; L Fratiglioni; Z Guo; M Viitanen; E von Strauss; B Winblad
Journal:  Am J Public Health       Date:  1998-10       Impact factor: 9.308

9.  Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study.

Authors:  Hans-Christoph Diener; Ralph L Sacco; Salim Yusuf; Daniel Cotton; Stephanie Ounpuu; William A Lawton; Yuko Palesch; Reneé H Martin; Gregory W Albers; Philip Bath; Natan Bornstein; Bernard P L Chan; Sien-Tsong Chen; Luis Cunha; Björn Dahlöf; Jacques De Keyser; Geoffrey A Donnan; Conrado Estol; Philip Gorelick; Vivian Gu; Karin Hermansson; Lutz Hilbrich; Markku Kaste; Chuanzhen Lu; Thomas Machnig; Prem Pais; Robin Roberts; Veronika Skvortsova; Philip Teal; Danilo Toni; Cam VanderMaelen; Thor Voigt; Michael Weber; Byung-Woo Yoon
Journal:  Lancet Neurol       Date:  2008-08-29       Impact factor: 44.182

10.  Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease.

Authors:  P G Kehoe; C Russ; S McIlory; H Williams; P Holmans; C Holmes; D Liolitsa; D Vahidassr; J Powell; B McGleenon; M Liddell; R Plomin; K Dynan; N Williams; J Neal; N J Cairns; G Wilcock; P Passmore; S Lovestone; J Williams; M J Owen
Journal:  Nat Genet       Date:  1999-01       Impact factor: 38.330
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  2 in total

1.  Small RNA modifications in Alzheimer's disease.

Authors:  Xudong Zhang; Fatima Trebak; Lucas A C Souza; Junchao Shi; Tong Zhou; Patrick G Kehoe; Qi Chen; Yumei Feng Earley
Journal:  Neurobiol Dis       Date:  2020-08-21       Impact factor: 5.996

2.  Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer's disease.

Authors:  Lucas A C Souza; Fatima Trebak; Veena Kumar; Ryousuke Satou; Patrick G Kehoe; Wei Yang; Whitney Wharton; Yumei Feng Earley
Journal:  Physiol Genomics       Date:  2020-01-21       Impact factor: 3.107
  2 in total

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