Julia F Taylor1, Mary A Ott2. 1. Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address: jft4p@virginia.edu. 2. Department of Pediatrics, Section of Adolescent Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Abstract
STUDY OBJECTIVE: Survival into adulthood is now a reality for many adolescents facing cancer. Fertility preservation (FP) is rapidly advancing, but oncology providers and health systems struggle to incorporate the newest FP technologies into the clinical care of adolescents. Our objective was to systematically review and synthesize the available data regarding the perspectives, experiences, and preferences of adolescents, parents, and oncology providers about FP to inform clinical implementation of FP technologies. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: Five electronic databases (PubMed, Embase, Web of Knowledge, Cumulative Index to Nursing and Allied Health Literature, PsychInfo) were systematically searched for studies published between January 1999 and May 2014. Adolescents were defined as 12-18 years at the time of diagnosis or designated as pubertal/postpubertal and younger than 18 years of age. Studies were assessed for methodological quality, data were extracted using a standardized form, and results were synthesized using guidelines for a narrative syntheses of quantitative and qualitative data. RESULTS: In total, 1237 records were identified, with 22 articles, representing 17 unique studies that met the inclusion criteria. The following topics were consistently observed across studies and populations: (1) fertility in trust; (2) decision-making challenges; (3) provider knowledge and practices; and (4) discrepancies between desired and actual experiences. CONCLUSION: Despite the challenges associated with a new cancer diagnosis, adolescents and parents value the opportunity to discuss fertility concerns and preservation options. Providers play an important role in addressing these topics for families and efforts should be made to incorporate FP discussions into routine cancer care for all adolescents, with attention paid to the unique needs of adolescents and their parents.
STUDY OBJECTIVE: Survival into adulthood is now a reality for many adolescents facing cancer. Fertility preservation (FP) is rapidly advancing, but oncology providers and health systems struggle to incorporate the newest FP technologies into the clinical care of adolescents. Our objective was to systematically review and synthesize the available data regarding the perspectives, experiences, and preferences of adolescents, parents, and oncology providers about FP to inform clinical implementation of FP technologies. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: Five electronic databases (PubMed, Embase, Web of Knowledge, Cumulative Index to Nursing and Allied Health Literature, PsychInfo) were systematically searched for studies published between January 1999 and May 2014. Adolescents were defined as 12-18 years at the time of diagnosis or designated as pubertal/postpubertal and younger than 18 years of age. Studies were assessed for methodological quality, data were extracted using a standardized form, and results were synthesized using guidelines for a narrative syntheses of quantitative and qualitative data. RESULTS: In total, 1237 records were identified, with 22 articles, representing 17 unique studies that met the inclusion criteria. The following topics were consistently observed across studies and populations: (1) fertility in trust; (2) decision-making challenges; (3) provider knowledge and practices; and (4) discrepancies between desired and actual experiences. CONCLUSION: Despite the challenges associated with a new cancer diagnosis, adolescents and parents value the opportunity to discuss fertility concerns and preservation options. Providers play an important role in addressing these topics for families and efforts should be made to incorporate FP discussions into routine cancer care for all adolescents, with attention paid to the unique needs of adolescents and their parents.
Authors: Kunj R Sheth; Vidit Sharma; Brian T Helfand; John Cashy; Kristin Smith; Jason C Hedges; Tobias S Köhler; Teresa K Woodruff; Robert E Brannigan Journal: J Urol Date: 2012-01-20 Impact factor: 7.450
Authors: Joyce D Reinecke; Joanne F Kelvin; Sarah R Arvey; Gwendolyn P Quinn; Jennifer Levine; Lindsay N Beck; Andy Miller Journal: J Oncol Pract Date: 2012-05-08 Impact factor: 3.840
Authors: Richard A Anderson; Annette Weddell; Helen A Spoudeas; Carolyn Douglas; Stephen M Shalet; Gill Levitt; W Hamish B Wallace Journal: Hum Reprod Date: 2008-07-09 Impact factor: 6.918
Authors: Heather Clayton; Gwendolyn P Quinn; Ji-Hyun Lee; Lindsey M King; Cheryl A Miree; Michael Nieder; Susan T Vadaparampil Journal: Oncol Nurs Forum Date: 2008-03 Impact factor: 2.172
Authors: Carrie L Nieman; Karen E Kinahan; Susan E Yount; Sarah K Rosenbloom; Kathleen J Yost; Elizabeth A Hahn; Timothy Volpe; Kimberley J Dilley; Laurie Zoloth; Teresa K Woodruff Journal: Cancer Treat Res Date: 2007
Authors: Giselle K Perez; John M Salsman; Kaitlyn Fladeboe; Anne C Kirchhoff; Elyse R Park; Abby R Rosenberg Journal: Am Soc Clin Oncol Educ Book Date: 2020-03
Authors: Natasha N Frederick; James L Klosky; Lillian R Meacham; Gwendolyn P Quinn; Joanne Frankel Kelvin; Brooke Cherven; David R Freyer; Christopher C Dvorak; Julienne Brackett; Sameeya Ahmed-Winston; Elyse Bryson; Eric J Chow; Jennifer Levine Journal: JCO Oncol Pract Date: 2021-10-28
Authors: Caroline S Dorfman; Juliann M Stalls; Coleman Mills; Shannon Voelkel; Mallori Thompson; Kelly S Acharya; Karen C Baker; Lars M Wagner; Nolan Miller; Amy Boswell; Cheyenne Corbett Journal: J Oncol Navig Surviv Date: 2021-10
Authors: Joceline V Vu; Natalia C Llarena; Samantha L Estevez; Molly B Moravek; Jacqueline S Jeruss Journal: J Surg Oncol Date: 2016-12-14 Impact factor: 3.454
Authors: Rebecca M Rentea; Ashwini S Poola; Joy M Fulbright; Shawn D St Peter; Sohail R Shah Journal: Pediatr Surg Int Date: 2018-04-04 Impact factor: 1.827
Authors: Lindsay F Schwartz; Clarence H Braddock; Roy L Kao; Myung-Shin Sim; Jacqueline N Casillas Journal: J Cancer Surviv Date: 2018-06-25 Impact factor: 4.442
Authors: Miriam D Langer; Ellen J Silver; Nancy A Dodson; Hina J Talib; Susan M Coupey Journal: J Pediatr Adolesc Gynecol Date: 2020-09-12 Impact factor: 1.814