J Katz1,2,3,4,5, M-A d'Albis1,2,3,4,5, J Boisgontier2,3,4,5, C Poupon6, J-F Mangin7, P Guevara8, D Duclap6, N Hamdani1,2,3,5, J Petit1,3, D Monnet1,3, P Le Corvoisier9,10, M Leboyer1,2,3,5, R Delorme11,12, J Houenou1,2,3,4,5. 1. AP-HP, Pôle de Psychiatrie, DHU PePsy, Hôpitaux Universitaires Mondor, Créteil, France. 2. Faculté de médecine, Université Paris Est, Créteil, France. 3. Fondation FondaMental, Créteil, France. 4. UNIACT Lab, Psychiatry Team, Neurospin, CEA Saclay, Gif sur Yvette, France. 5. INSERM, U955 Equipe 15 «Psychiatrie Translationnelle», IMRB, Créteil, France. 6. UNIRS Lab, Neurospin, CEA Saclay, Gif sur Yvette, France. 7. UNATI Lab, Neurospin, CEA Saclay, Gif sur Yvette, France. 8. Department of Electrical Engineering, Universidad de Concepcion, Concepcion, Chile. 9. Centre d'Investigation Clinique 1430, INSERM, Créteil, France. 10. APHP, GH Henri Mondor, Créteil, France. 11. Human Genetics and Cognitive Functions, CNRS URA 2182 'Genes, Synapses and Cognition', Institut Pasteur, Paris, France. 12. APHP, Department of Child and Adolescent Psychiatry, Robert Debré Hospital, Paris, France.
Abstract
OBJECTIVE: High-functioning autism (HFA) and schizophrenia (SZ) are two of the main neurodevelopmental disorders, sharing several clinical dimensions and risk factors. Their exact relationship is poorly understood, and few studies have directly compared both disorders. Our aim was thus to directly compare neuroanatomy of HFA and SZ using a multimodal MRI design. METHODS: We scanned 79 male adult subjects with 3T MRI (23 with HFA, 24 with SZ and 32 healthy controls, with similar non-verbal IQ). We compared them using both diffusion-based whole-brain tractography and T1 voxel-based morphometry. RESULTS: HFA and SZ groups exhibited similar white matter alterations in the left fronto-occipital inferior fasciculus with a decrease in generalized fractional anisotropy compared with controls. In grey matter, the HFA group demonstrated bilateral prefrontal and anterior cingulate increases in contrast with prefrontal and left temporal reductions in SZ. CONCLUSION: HFA and SZ may share common white matter deficits in long-range connections involved in social functions, but opposite grey matter abnormalities in frontal regions that subserve complex cognitive functions. Our results are consistent with the fronto-occipital underconnectivity theory of HFA and the altered connectivity hypothesis of SZ and suggest the existence of both associated and diametrical liabilities to these two conditions.
OBJECTIVE: High-functioning autism (HFA) and schizophrenia (SZ) are two of the main neurodevelopmental disorders, sharing several clinical dimensions and risk factors. Their exact relationship is poorly understood, and few studies have directly compared both disorders. Our aim was thus to directly compare neuroanatomy of HFA and SZ using a multimodal MRI design. METHODS: We scanned 79 male adult subjects with 3T MRI (23 with HFA, 24 with SZ and 32 healthy controls, with similar non-verbal IQ). We compared them using both diffusion-based whole-brain tractography and T1 voxel-based morphometry. RESULTS:HFA and SZ groups exhibited similar white matter alterations in the left fronto-occipital inferior fasciculus with a decrease in generalized fractional anisotropy compared with controls. In grey matter, the HFA group demonstrated bilateral prefrontal and anterior cingulate increases in contrast with prefrontal and left temporal reductions in SZ. CONCLUSION:HFA and SZ may share common white matter deficits in long-range connections involved in social functions, but opposite grey matter abnormalities in frontal regions that subserve complex cognitive functions. Our results are consistent with the fronto-occipital underconnectivity theory of HFA and the altered connectivity hypothesis of SZ and suggest the existence of both associated and diametrical liabilities to these two conditions.
Authors: Covadonga M Díaz-Caneja; Hugo Schnack; Kenia Martínez; Javier Santonja; Yasser Alemán-Gomez; Laura Pina-Camacho; Carmen Moreno; David Fraguas; Celso Arango; Mara Parellada; Joost Janssen Journal: Hum Brain Mapp Date: 2018-12-19 Impact factor: 5.038
Authors: Serge A Mitelman; Marie-Cecile Bralet; M Mehmet Haznedar; Eric Hollander; Lina Shihabuddin; Erin A Hazlett; Monte S Buchsbaum Journal: Brain Imaging Behav Date: 2018-04 Impact factor: 3.978
Authors: Haixia Zheng; Maurizio Bergamino; Bart N Ford; Rayus Kuplicki; Fang-Cheng Yeh; Jerzy Bodurka; Kaiping Burrows; Peter W Hunt; T Kent Teague; Michael R Irwin; Robert H Yolken; Martin P Paulus; Jonathan Savitz Journal: Neuropsychopharmacology Date: 2021-01-26 Impact factor: 7.853
Authors: Laurena Holleran; Sinead Kelly; Clara Alloza; Ingrid Agartz; Ole A Andreassen; Celso Arango; Nerisa Banaj; Vince Calhoun; Dara Cannon; Vaughan Carr; Aiden Corvin; David C Glahn; Ruben Gur; Elliot Hong; Cyril Hoschl; Fleur M Howells; Anthony James; Joost Janssen; Peter Kochunov; Stephen M Lawrie; Jingyu Liu; Covadonga Martinez; Colm McDonald; Derek Morris; David Mothersill; Christos Pantelis; Fabrizio Piras; Steven Potkin; Paul E Rasser; David Roalf; Laura Rowland; Theodore Satterthwaite; Ulrich Schall; Gianfranco Spalletta; Filip Spaniel; Dan J Stein; Anne Uhlmann; Aristotle Voineskos; Andrew Zalesky; Theo G M van Erp; Jessica A Turner; Ian J Deary; Paul M Thompson; Neda Jahanshad; Gary Donohoe Journal: Am J Psychiatry Date: 2020-03-26 Impact factor: 18.112