Sarah M Haigh1, Shaun M Eack2, Timothy Keller3, Nancy J Minshew4, Marlene Behrmann5. 1. Department of Psychology, Carnegie Mellon University, USA; Center for the Neural Basis of Cognition, Carnegie Mellon University, USA; Department of Psychology and Center for Integrative Neuroscience, University of Nevada, Reno, USA. Electronic address: shaigh@unr.edu. 2. Department of Psychiatry, University of Pittsburgh School of Medicine, USA; School of Social Work, University of Pittsburgh, USA. 3. Department of Psychology, Carnegie Mellon University, USA. 4. Department of Psychiatry, University of Pittsburgh School of Medicine, USA; Department of Neurology, University of Pittsburgh, USA. 5. Department of Psychology, Carnegie Mellon University, USA; Center for the Neural Basis of Cognition, Carnegie Mellon University, USA.
Abstract
BACKGROUND: Schizophrenia and autism share many behavioral and neurological similarities, including altered white matter tract structure. However, because schizophrenia and autism are rarely compared directly, it is difficult to establish whether white matter abnormalities are disorder-specific or are common across these disorders that share some symptomatology. METHODS: In the current study, we compared white matter water diffusion using tensor imaging in 25 adults with autism, 15 adults with schizophrenia, all with IQ scores above 88, and 19 neurotypical adults. RESULTS: Although the three groups evinced no statistically significant differences in measures of fractional anisotropy (FA), the schizophrenia group showed significantly greater mean diffusivity (MD; Cohen's d > 0.77), due to greater radial diffusivity (RD; Cohen's d > 0.92), compared to both the autism and control groups. This effect was evident across the brain rather than specific to a particular tract. CONCLUSIONS: The greater MD and RD in schizophrenia appears to be diagnosis-specific. The altered diffusion may reflect subtle abnormalities in myelination, which could be a potential mechanism underlying the widespread behavioral deficits associated with schizophrenia.
BACKGROUND:Schizophrenia and autism share many behavioral and neurological similarities, including altered white matter tract structure. However, because schizophrenia and autism are rarely compared directly, it is difficult to establish whether white matter abnormalities are disorder-specific or are common across these disorders that share some symptomatology. METHODS: In the current study, we compared white matter water diffusion using tensor imaging in 25 adults with autism, 15 adults with schizophrenia, all with IQ scores above 88, and 19 neurotypical adults. RESULTS: Although the three groups evinced no statistically significant differences in measures of fractional anisotropy (FA), the schizophrenia group showed significantly greater mean diffusivity (MD; Cohen's d > 0.77), due to greater radial diffusivity (RD; Cohen's d > 0.92), compared to both the autism and control groups. This effect was evident across the brain rather than specific to a particular tract. CONCLUSIONS: The greater MD and RD in schizophrenia appears to be diagnosis-specific. The altered diffusion may reflect subtle abnormalities in myelination, which could be a potential mechanism underlying the widespread behavioral deficits associated with schizophrenia.
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