Literature DB >> 27103866

The association of consumptive hypothyroidism secondary to hepatic hemangioma and severe heart failure in infancy.

Suna Emir1, Filiz Ekici2, Mehmet Alper İkiz1, Sadi Vidinlisan3.   

Abstract

Although hemangiomas are the most common vascular tumors of the liver in infancy, data regarding hypothyroidism and heart failure related to hepatic hemangiomas are limited. Here, we present a 15- day -old girl who presented with prolonged jaundice at the age of 15 days. Because her TSH level was found to be 74 μIU/mL, she was initially diagnosed with congenital hypothyroidism and L-Thyroxine replacement therapy was initiated. On follow-up examination performed two months later, it was observed that her TSH level was not suppressed and a mass was noticed in the right upper abdomen on physical examination. Abdominal ultrasonography revealed multiple masses with sizes of about 3-3,5 cm covering the whole liver. When evaluated with clinical and radiological appearance, oral methylprednisolone at a dose of 5 mg/kg/day and propranolol at a dose of 2 mg/kg were initiated with a diagnosis of hepatic hemagioma/hemangioendothelioma. Consumptive hypothyroidism due to hepatic hemangioma and congestive heart failure were considered in the patient who had findings of heart failure. The dose of L-Thyroxine was increased 2-fold. The patient received intensive care treatment for severe heart failure. Because his findings resolved, he was started to be followed up with propranolol, steroid and L-Thyroxine treatment.

Entities:  

Keywords:  Hypothyroidism; heart failure; hepatic hemangioma; infant

Year:  2016        PMID: 27103866      PMCID: PMC4829168          DOI: 10.5152/TurkPediatriArs.2016.1548

Source DB:  PubMed          Journal:  Turk Pediatri Ars


  13 in total

1.  Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry.

Authors:  Emily R Christison-Lagay; Patricia E Burrows; Ahmad Alomari; Josée Dubois; Harry P Kozakewich; Tricia S Lane; Harriet J Paltiel; Giannoula Klement; John B Mulliken; Steven J Fishman
Journal:  J Pediatr Surg       Date:  2007-01       Impact factor: 2.545

2.  Severe hypothyroidism caused by hepatic hemangioendothelioma in an infant of a diabetic mother.

Authors:  Ayla Güven; Canan Aygun; Hülya Ince; Murat Aydin; F Güçlü Pinarli; Kemal Baysal; Sükrü Küçüködük
Journal:  Horm Res       Date:  2005

3.  Malignant vascular tumors of liver in neonates.

Authors:  Zafar Nazir; Shahid Pervez
Journal:  J Pediatr Surg       Date:  2006-01       Impact factor: 2.545

4.  Hepatic hemangioendothelioma associated with production of humoral thyrotropin-like factor.

Authors:  R M Ayling; M Davenport; N Hadzic; R Metcalfe; C R Buchanan; E R Howard; G Mieli-Vergani
Journal:  J Pediatr       Date:  2001-06       Impact factor: 4.406

Review 5.  Multifocal infantile hepatic hemangiomas--imaging strategy and response to treatment after propranolol and steroids including review of the literature.

Authors:  Thangamadhan Bosemani; Katherine B Puttgen; Thierry A G M Huisman; Aylin Tekes
Journal:  Eur J Pediatr       Date:  2012-01-11       Impact factor: 3.183

6.  Infantile hepatic hemangioendothelioma: a clinicopathologic study in a Chinese population.

Authors:  Zhang Zhang; Hui-Jiao Chen; Wen-Juan Yang; Hong Bu; Bing Wei; Xiao-Yu Long; Jing Fu; Rui Zhang; Yun-Bi Ni; Hong-Ying Zhang
Journal:  World J Gastroenterol       Date:  2010-09-28       Impact factor: 5.742

7.  Spontaneous regression of severe acquired infantile hypothyroidism associated with multiple liver hemangiomas.

Authors:  Daniel Konrad; Graham Ellis; Kusiel Perlman
Journal:  Pediatrics       Date:  2003-12       Impact factor: 7.124

8.  Thyroid abnormalities in infantile hepatic hemangioendothelioma.

Authors:  Ram Kalpatthi; John Germak; Katherine Mizelle; Nicholas Yeager
Journal:  Pediatr Blood Cancer       Date:  2007-12       Impact factor: 3.167

9.  Recombinant interferon alfa 2a in hepatic hemangiomatosis with congestive heart failure: a case report.

Authors:  A Schiavetti; M D De Pasquale; S Di Salvo; F Ventriglia; A Clerico
Journal:  Pediatr Hematol Oncol       Date:  2003-03       Impact factor: 1.969

10.  Hypothyroidism due to hepatic hemangioendothelioma: a case report.

Authors:  Semra Çetinkaya; Havva Nur Peltek Kendirci; Sebahat Yilmaz Ağladioğlu; Veysel Nijat Baş; Sonay Özdemir; Ceyhun Bozkurt; Zehra Aycan
Journal:  J Clin Res Pediatr Endocrinol       Date:  2010-08-07
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  3 in total

1.  Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome.

Authors:  Marina Weber Pasa; Rafael Selbach Scheffel; André Borsatto Zanella; Ana Luiza Maia; José Miguel Dora
Journal:  Eur Thyroid J       Date:  2017-10-13

2.  Diffuse hepatic hemangioma with single cutaneous hemangioma: an alerting occurrence.

Authors:  Faten Al Tasseh; Merna El-Khansa; Omran Abd; Anoir Abdel Khalek; Nahida El-Rifai
Journal:  Clin Case Rep       Date:  2017-04-24

3.  Resolution of Consumptive Hypothyroidism Secondary to Infantile Hepatic Hemangiomatosis with a Combination of Propranolol and Levothyroxine

Authors:  Victoria Campbell; Rachel Beckett; Noina Abid; Susannah Hoey
Journal:  J Clin Res Pediatr Endocrinol       Date:  2018-02-28
  3 in total

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