Literature DB >> 22234480

Multifocal infantile hepatic hemangiomas--imaging strategy and response to treatment after propranolol and steroids including review of the literature.

Thangamadhan Bosemani1, Katherine B Puttgen, Thierry A G M Huisman, Aylin Tekes.   

Abstract

Infantile hepatic hemangioma is the most common benign liver tumor during infancy. Prompt diagnosis and timely institution of therapy are of utmost importance. Magnetic resonance imaging (MRI) plays a key role in the correct diagnosis and monitoring of treatment. We report on a 15-week-old girl with multifocal infantile hemangiomas of the liver and high output congestive heart failure. Diagnosis was confirmed by MRI. Subsequent treatment with propranolol and steroids showed dramatic regression of the lesions within 24 weeks. We present the characteristic MRI findings and discuss treatment options together with a comprehensive review of the relevant literature. Conclusion Propranolol appears highly efficacious in the management of infantile hepatic hemangioma; dedicated MRI is essential in confirming the diagnosis and monitoring of treatment.

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Year:  2012        PMID: 22234480     DOI: 10.1007/s00431-011-1671-7

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN: 0340-6199            Impact factor:   3.183


  10 in total

Review 1.  Propranolol for infantile haemangiomas: insights into the molecular mechanisms of action.

Authors:  C H Storch; P H Hoeger
Journal:  Br J Dermatol       Date:  2010-05-08       Impact factor: 9.302

2.  Diffuse infantile hepatic hemangiomas: a report of four cases successfully managed with medical therapy.

Authors:  Iwei Yeh; Anna L Bruckner; Rosa Sanchez; Michael R Jeng; Brandon D Newell; Ilona J Frieden
Journal:  Pediatr Dermatol       Date:  2011-04-26       Impact factor: 1.588

3.  Response of infantile hepatic hemangioma to propranolol resistant to high-dose methylprednisolone and interferon-α therapy.

Authors:  Faik Sarialioglu; Ayse Erbay; Senay Demir
Journal:  Pediatr Blood Cancer       Date:  2010-12-15       Impact factor: 3.167

4.  Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry.

Authors:  Emily R Christison-Lagay; Patricia E Burrows; Ahmad Alomari; Josée Dubois; Harry P Kozakewich; Tricia S Lane; Harriet J Paltiel; Giannoula Klement; John B Mulliken; Steven J Fishman
Journal:  J Pediatr Surg       Date:  2007-01       Impact factor: 2.545

5.  Propranolol for severe hemangiomas of infancy.

Authors:  Christine Léauté-Labrèze; Eric Dumas de la Roque; Thomas Hubiche; Franck Boralevi; Jean-Benoît Thambo; Alain Taïeb
Journal:  N Engl J Med       Date:  2008-06-12       Impact factor: 91.245

6.  Efficacy of propranolol in hepatic infantile hemangiomas with diffuse neonatal hemangiomatosis.

Authors:  Juliette Mazereeuw-Hautier; Peter H Hoeger; Sarah Benlahrech; Amir Ammour; Pierre Broue; Julie Vial; Gerard Ohanessian; Christine Léauté-Labrèze; Marc Labenne; Pierre Vabres; Jochen Rössler; Christine Bodemer
Journal:  J Pediatr       Date:  2010-05-20       Impact factor: 4.406

7.  Hepatic infantile hemangiomas treated with oral propranolol--a case series.

Authors:  Amal Mhanna; Wayne H Franklin; Anthony J Mancini
Journal:  Pediatr Dermatol       Date:  2011-01-25       Impact factor: 1.588

8.  Efficacy and safety of propranolol as first-line treatment for infantile hemangiomas.

Authors:  Clemens Schiestl; Kathrin Neuhaus; Silke Zoller; Ulrike Subotic; Ishilde Forster-Kuebler; Rike Michels; Christian Balmer; Lisa Weibel
Journal:  Eur J Pediatr       Date:  2010-10-09       Impact factor: 3.183

Review 9.  Hepatic vascular anomalies in infancy: a twenty-seven-year experience.

Authors:  L M Boon; P E Burrows; H J Paltiel; D P Lund; R A Ezekowitz; J Folkman; J B Mulliken
Journal:  J Pediatr       Date:  1996-09       Impact factor: 4.406

10.  Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics.

Authors:  J B Mulliken; J Glowacki
Journal:  Plast Reconstr Surg       Date:  1982-03       Impact factor: 4.730

  10 in total
  8 in total

1.  The association of consumptive hypothyroidism secondary to hepatic hemangioma and severe heart failure in infancy.

Authors:  Suna Emir; Filiz Ekici; Mehmet Alper İkiz; Sadi Vidinlisan
Journal:  Turk Pediatri Ars       Date:  2016-03-01

Review 2.  Treatment of infantile haemangiomas: recommendations of a European expert group.

Authors:  Peter H Hoeger; John I Harper; Eulalia Baselga; Damien Bonnet; Laurence M Boon; Marta Ciofi Degli Atti; Maya El Hachem; Arnold P Oranje; Agneta Troilius Rubin; Lisa Weibel; Christine Léauté-Labrèze
Journal:  Eur J Pediatr       Date:  2015-05-29       Impact factor: 3.183

Review 3.  Infantile hepatic hemangiomas: looking backwards and forwards.

Authors:  Xue Gong; Yanan Li; Kaiying Yang; Siyuan Chen; Yi Ji
Journal:  Precis Clin Med       Date:  2022-02-11

Review 4.  Infantile hepatic hemangioma: current state of the art, controversies, and perspectives.

Authors:  Nikolaos Zavras; Anastasia Dimopoulou; Nikolaos Machairas; Anna Paspala; George Vaos
Journal:  Eur J Pediatr       Date:  2019-11-22       Impact factor: 3.183

5.  Safety and effectiveness of oral propranolol for infantile hemangiomas started before 5 weeks and after 5 months of age: an Italian multicenter experience.

Authors:  Maya El Hachem; Francesco Gesualdo; Andrea Diociaiuti; Irene Berti; Nadia Vercellino; Valeria Boccaletti; Iria Neri; Giulio Porcedda; Antonella Greco; Claudia Carnevale; Teresa Oranges; Mario Cutrone; Pietro Dalmonte
Journal:  Ital J Pediatr       Date:  2017-04-19       Impact factor: 2.638

6.  Peritoneal cavernous hemangiomatosis: A case report.

Authors:  Li-Yuan Fu; Hong-Yu Chen; Xiao-Li Diao; Zhen-Jun Wang
Journal:  World J Clin Cases       Date:  2019-02-26       Impact factor: 1.337

7.  Infantile Hepatic Hemangioendothelioma: An Uncommon Cause of Persistent Pulmonary Hypertension in a Newborn Infant.

Authors:  Trassanee Chatmethakul; Ramachandra Bhat; Maryam Alkaabi; Abdul Siddiqui; Keith Peevy; Michael Zayek
Journal:  AJP Rep       Date:  2016-07

8.  Neonatal giant hepatic hemangioma: A case report.

Authors:  Zhenwei Zhu; Peng Cai; Jie Zhu; Jianlei Chen; Bin Wu; Zhicheng Gu; Shungen Huang; Jian Wang
Journal:  Medicine (Baltimore)       Date:  2018-10       Impact factor: 1.817

  8 in total

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