Literature DB >> 27094192

Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience.

Bangkun Yang1,2, Chun Yang1, Qian Ren1, Ji-Chun Zhang1, Qian-Xue Chen2, Yukihiko Shirayama1,3, Kenji Hashimoto4.   

Abstract

Using learned helplessness (LH) model of depression, we measured protein expression of brain-derived neurotrophic factor (BDNF) pro-peptide, BDNF precursors (proBDNF and preproBDNF) in the brain regions of LH (susceptible) and non-LH rats (resilience). Expression of preproBDNF, proBDNF and BDNF pro-peptide in the medial prefrontal cortex of LH rats, but not non-LH rats, was significantly higher than control rats, although expression of these proteins in the nucleus accumbens of LH rats was significantly lower than control rats. This study suggests that regional differences in conversion of BDNF precursors into BDNF and BDNF pro-peptide by proteolytic cleavage may contribute to stress resilience.

Entities:  

Keywords:  BDNF; BDNF pro-peptide; Depression; Learned helplessness; Stress resilience; proBDNF

Mesh：

Substances：

Year:  2016        PMID： 27094192     DOI： 10.1007/s00406-016-0693-6

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Clin Neurosci        ISSN： 0940-1334            Impact factor:   5.270


  15 in total

Review 1.  Altering BDNF expression by genetics and/or environment: impact for emotional and depression-like behaviour in laboratory mice.

Authors:  Sabine Chourbaji; Christiane Brandwein; Peter Gass
Journal:  Neurosci Biobehav Rev       Date:  2010-07-17       Impact factor: 8.989

Review 2.  Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions.

Authors:  Kenji Hashimoto
Journal:  Psychiatry Clin Neurosci       Date:  2010-08       Impact factor: 5.188

3.  Regulation of brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain by serotonin.

Authors:  Kenji Hashimoto
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2016-04       Impact factor: 5.270

Review 4.  Critical role of brain-derived neurotrophic factor in mood disorders.

Authors:  Kenji Hashimoto; Eiji Shimizu; Masaomi Iyo
Journal:  Brain Res Brain Res Rev       Date:  2004-05

5.  Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression.

Authors:  Ji-chun Zhang; Wei Yao; Chao Dong; Chun Yang; Qian Ren; Min Ma; Mei Han; Kenji Hashimoto
Journal:  Psychopharmacology (Berl)       Date:  2015-09-04       Impact factor: 4.530

6.  BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met.

Authors:  Toshiyuki Mizui; Yasuyuki Ishikawa; Haruko Kumanogoh; Maria Lume; Tomoya Matsumoto; Tomoko Hara; Shigeto Yamawaki; Masami Takahashi; Sadao Shiosaka; Chiaki Itami; Koichi Uegaki; Mart Saarma; Masami Kojima
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-26       Impact factor: 11.205

7.  Regional differences in brain-derived neurotrophic factor levels and dendritic spine density confer resilience to inescapable stress.

Authors:  Chun Yang; Yukihiko Shirayama; Ji-Chun Zhang; Qian Ren; Kenji Hashimoto
Journal:  Int J Neuropsychopharmacol       Date:  2015-01-07       Impact factor: 5.176

8.  Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation.

Authors:  Ji-chun Zhang; Jin Wu; Yuko Fujita; Wei Yao; Qian Ren; Chun Yang; Su-xia Li; Yukihiko Shirayama; Kenji Hashimoto
Journal:  Int J Neuropsychopharmacol       Date:  2014-10-31       Impact factor: 5.176

Review 9.  Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets.

Authors:  Ji-Chun Zhang; Wei Yao; Kenji Hashimoto
Journal:  Curr Neuropharmacol       Date:  2016       Impact factor: 7.363

10.  R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects.

Authors:  C Yang; Y Shirayama; J-c Zhang; Q Ren; W Yao; M Ma; C Dong; K Hashimoto
Journal:  Transl Psychiatry       Date:  2015-09-01       Impact factor: 6.222
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  25 in total

Review 1.  PROneurotrophins and CONSequences.

Authors:  Rui O Costa; Tânia Perestrelo; Ramiro D Almeida
Journal:  Mol Neurobiol       Date:  2017-04-29       Impact factor: 5.590

2.  Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression.

Authors:  Yukihiko Shirayama; Kenji Hashimoto
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2016-08-01       Impact factor: 5.270

3.  Keap1-Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress.

Authors:  Ji-Chun Zhang; Wei Yao; Chao Dong; Mei Han; Yukihiko Shirayama; Kenji Hashimoto
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2017-11-08       Impact factor: 5.270

4.  Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB receptor in the mesolimbic system.

Authors:  Sandra Montagud-Romero; Cristina Nuñez; M Carmen Blanco-Gandia; Elena Martínez-Laorden; María A Aguilar; Javier Navarro-Zaragoza; Pilar Almela; Maria-Victoria Milanés; María-Luisa Laorden; José Miñarro; Marta Rodríguez-Arias
Journal:  Psychopharmacology (Berl)       Date:  2017-05-02       Impact factor: 4.530

5.  Sustained antidepressant action of the N-methyl-D-aspartate receptor antagonist MK-801 in a chronic unpredictable mild stress model.

Authors:  Bang-Kun Yang; Jun Qin; Ying Nie; Jin-Cao Chen
Journal:  Exp Ther Med       Date:  2018-10-18       Impact factor: 2.447

6.  PGC-1α-FNDC5-BDNF signaling pathway in skeletal muscle confers resilience to stress in mice subjected to chronic social defeat.

Authors:  Gaofeng Zhan; Niannian Huang; Shan Li; Dongyu Hua; Jie Zhang; Xi Fang; Ning Yang; Ailin Luo; Chun Yang
Journal:  Psychopharmacology (Berl)       Date:  2018-09-26       Impact factor: 4.530

7.  Corticosterone Induced the Increase of proBDNF in Primary Hippocampal Neurons Via Endoplasmic Reticulum Stress.

Authors:  Yu Liu; Guang-Jing Zou; Bo-Xuan Tu; Zhao-Lan Hu; Cong Luo; Yan-Hui Cui; Yang Xu; Fang Li; Ru-Ping Dai; Fang-Fang Bi; Chang-Qi Li
Journal:  Neurotox Res       Date:  2020-05-06       Impact factor: 3.911

8.  Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling.

Authors:  Min Ma; Qian Ren; Chun Yang; Ji-Chun Zhang; Wei Yao; Chao Dong; Yuta Ohgi; Takashi Futamura; Kenji Hashimoto
Journal:  Sci Rep       Date:  2016-12-19       Impact factor: 4.379

9.  Brain-derived neurotrophic factor propeptide inhibits proliferation and induces apoptosis in C6 glioma cells.

Authors:  Bangkun Yang; Jun Qin; Ying Nie; Yong Li; Qianxue Chen
Journal:  Neuroreport       Date:  2017-08-16       Impact factor: 1.837

10.  Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription.

Authors:  Rui Tang; Qian-Qian Cao; Sheng-Wei Hu; Lu-Juan He; Peng-Fei Du; Gang Chen; Rao Fu; Fei Xiao; Yi-Rong Sun; Ji-Chun Zhang; Qi Qi
Journal:  Acta Pharmacol Sin       Date:  2021-07-16       Impact factor: 6.150
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