Literature DB >> 29119264

Keap1-Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress.

Ji-Chun Zhang1, Wei Yao1, Chao Dong1, Mei Han1, Yukihiko Shirayama1,2, Kenji Hashimoto3.   

Abstract

The transcription factor Keap1-Nrf2 signaling plays a key role in the oxidative stress which is involved in psychiatric disorders. In the learned helplessness (LH) paradigm, protein levels of Keap1 and Nrf2 in the prefrontal cortex and dentate gyrus of hippocampus from LH (susceptible) rats were lower than control and non-LH (resilience) rats. Furthermore, protein expressions of Keap1 and Nrf2 in the parietal cortex from major depressive disorder, schizophrenia, and bipolar disorder were lower than controls. These results suggest that Keap1-Nrf2 signaling might contribute to stress resilience which plays a key role in the pathophysiology of psychiatric disorders.

Entities:  

Keywords:  Learned helplessness; Oxidative stress; Postmortem brain; Resilience

Mesh：

Substances：

Year:  2017        PMID： 29119264     DOI： 10.1007/s00406-017-0848-0

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Clin Neurosci        ISSN： 0940-1334            Impact factor:   5.270


  26 in total

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Journal:  Psychoneuroendocrinology       Date:  2013-04-23       Impact factor: 4.905

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6.  Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood.

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7.  Regional differences in brain-derived neurotrophic factor levels and dendritic spine density confer resilience to inescapable stress.

Authors:  Chun Yang; Yukihiko Shirayama; Ji-Chun Zhang; Qian Ren; Kenji Hashimoto
Journal:  Int J Neuropsychopharmacol       Date:  2015-01-07       Impact factor: 5.176

Review 8.  Inflammatory biomarkers as differential predictors of antidepressant response.

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9.  Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation.

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  21 in total

Review 1.  Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry.

Authors:  G Morris; A J Walker; K Walder; M Berk; W Marx; A F Carvalho; M Maes; B K Puri
Journal:  Mol Neurobiol       Date:  2021-01-07       Impact factor: 5.590

2.  Upregulating Nrf2 in the RVLM ameliorates sympatho-excitation in mice with chronic heart failure.

Authors:  Anyun Ma; Juan Hong; Julia Shanks; Tara Rudebush; Li Yu; Bryan T Hackfort; Hanjun Wang; Irving H Zucker; Lie Gao
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Review 3.  Recent Advances in the Early Intervention in Schizophrenia: Future Direction from Preclinical Findings.

Authors:  Kenji Hashimoto
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Review 4.  Recent Reports on Redox Stress-Induced Mitochondrial DNA Variations, Neuroglial Interactions, and NMDA Receptor System in Pathophysiology of Schizophrenia.

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Review 5.  Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia.

Authors:  Gerwyn Morris; Luba Sominsky; Kenneth R Walder; Michael Berk; Wolfgang Marx; André F Carvalho; Chiara C Bortolasci; Michael Maes; Basant K Puri
Journal:  Mol Neurobiol       Date:  2022-03-26       Impact factor: 5.682

6.  Increased expression of soluble epoxide hydrolase in the brain and liver from patients with major psychiatric disorders: A role of brain - liver axis.

Authors:  Jiancheng Zhang; Yunfei Tan; Lijia Chang; Bruce D Hammock; Kenji Hashimoto
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7.  Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane.

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8.  Dietary glucoraphanin prevents the onset of psychosis in the adult offspring after maternal immune activation.

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Journal:  Sci Rep       Date:  2018-02-01       Impact factor: 4.379

9.  The efficacy and safety of sulforaphane as an adjuvant in the treatment of bipolar depressive disorder: Study protocol for a randomized, double-blinded, placebo-controlled, parallel-group clinical trial.

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Journal:  Medicine (Baltimore)       Date:  2020-06-26       Impact factor: 1.817

10.  Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription.

Authors:  Rui Tang; Qian-Qian Cao; Sheng-Wei Hu; Lu-Juan He; Peng-Fei Du; Gang Chen; Rao Fu; Fei Xiao; Yi-Rong Sun; Ji-Chun Zhang; Qi Qi
Journal:  Acta Pharmacol Sin       Date:  2021-07-16       Impact factor: 6.150
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