Literature DB >> 27480092

Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression.

Yukihiko Shirayama1,2, Kenji Hashimoto3.   

Abstract

Effects of a single bilateral infusion of R-enantiomer of ketamine in rat brain regions of learned helplessness model of depression were examined. A single bilateral infusion of R-ketamine into infralimbic (IL) portion of medial prefrontal cortex (mPFC), CA3 and dentate gyrus (DG) of the hippocampus showed antidepressant effects. By contrast, a single bilateral infusion of R-ketamine into prelimbic (PL) portion of mPFC, shell and core of nucleus accumbens, basolateral amygdala and central nucleus of the amygdala had no effect. This study suggests that IL of mPFC, CA3 and DG of hippocampus might be involved in the antidepressant actions of R-ketamine.

Entities:  

Keywords:  Antidepressant effect; Infralimbic cortex; Learned helplessness; R-ketamine

Mesh：

Substances：

Year:  2016        PMID： 27480092     DOI： 10.1007/s00406-016-0718-1

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Clin Neurosci        ISSN： 0940-1334            Impact factor:   5.270


  24 in total

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