| Literature DB >> 16945530 |
Gaiying Zhao1, Marvin J Miller, Scott Franzblau, Baojie Wan, Ute Möllmann.
Abstract
The syntheses and anti-tuberculosis activity of quinolone-cephalosporin conjugates (1 and 2) are described. Both showed broad-spectrum antibacterial activity and significant anti-TB activity. The carbamate-linked quinolone-cephem 2 showed better antimycobacterial activity, including anti-TB activity, than the direct amine-linked quinolone-cephem 1, while quinolone-cephem 1 was slightly more effective against some Gram-negative bacterial strains.Entities:
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Year: 2006 PMID： 16945530 DOI： 10.1016/j.bmcl.2006.08.045
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823