Joon Soon Kang1,2, Kyoung Ho Moon3, Bom Soo Kim3, Seong Jo Yang3. 1. Department of Orthopedic Surgery, College of Medicine, Inha University, Incheon, Korea. kangjoon@inha.ac.kr. 2. Department of Orthopedic Surgery, Inha University Hospital, 27, Inhang-ro, Jung-gu, Incheon, 22332, Korea. kangjoon@inha.ac.kr. 3. Department of Orthopedic Surgery, College of Medicine, Inha University, Incheon, Korea.
Abstract
PURPOSE: The purpose of this study was to assess the efficacy of a newly designed topical administration of tranexamic acid (TXA) in reducing post-operative bleeding in total hip arthroplasty (THA) and bipolar hip hemiarthroplasty (BHA). METHODS: A consecutive series of 160 patients who underwent hip arthroplasty was enrolled in this study. Topical administration of TXA was done in group 1 (40 patients underwent THA and 40 BHA). We compared the amount of blood loss and rates of post-operative transfusion in group 1 with those of group 2 (40 cases of THA and 40 cases of BHA) in which TXA solution was not applied. RESULTS: The total amount of blood loss in THA group 1 and THA group 2 was 793 ± 50 mL and 1086 ± 73 mL, respectively (p = 0.001). The transfusion rates of THA group 1 and THA group 2 was 27.5 % and 50 %, respectively (p = 0.039). The transfusion rates of BHA group 1 and BHA group 2 was 45 % and 60 %, respectively (p = 0.179). The amounts of blood loss through the drainage tube were 186 ± 22 mL and 257 ± 24 mL in THA group 1 and THA group 2, respectively, and 101 ± 11 mL and 147 ± 16 mL in BHA group 1 and BHA group 2, respectively, showing statistical significance. No complications such as infection, deep vein thrombosis or cardiovascular disease were observed during the hospital stay and the last follow-up. CONCLUSION: Topical administration of TXA is an effective and safe method to reduce post-operative bleeding and transfusion rates in hip arthroplasty.
PURPOSE: The purpose of this study was to assess the efficacy of a newly designed topical administration of tranexamic acid (TXA) in reducing post-operative bleeding in total hip arthroplasty (THA) and bipolar hip hemiarthroplasty (BHA). METHODS: A consecutive series of 160 patients who underwent hip arthroplasty was enrolled in this study. Topical administration of TXA was done in group 1 (40 patients underwent THA and 40 BHA). We compared the amount of blood loss and rates of post-operative transfusion in group 1 with those of group 2 (40 cases of THA and 40 cases of BHA) in which TXA solution was not applied. RESULTS: The total amount of blood loss in THA group 1 and THA group 2 was 793 ± 50 mL and 1086 ± 73 mL, respectively (p = 0.001). The transfusion rates of THA group 1 and THA group 2 was 27.5 % and 50 %, respectively (p = 0.039). The transfusion rates of BHA group 1 and BHA group 2 was 45 % and 60 %, respectively (p = 0.179). The amounts of blood loss through the drainage tube were 186 ± 22 mL and 257 ± 24 mL in THA group 1 and THA group 2, respectively, and 101 ± 11 mL and 147 ± 16 mL in BHA group 1 and BHA group 2, respectively, showing statistical significance. No complications such as infection, deep vein thrombosis or cardiovascular disease were observed during the hospital stay and the last follow-up. CONCLUSION: Topical administration of TXA is an effective and safe method to reduce post-operative bleeding and transfusion rates in hip arthroplasty.
Entities:
Keywords:
Hip arthroplasty; Post-operative bleeding; Topical administration; Tranexamic acid
Authors: Joseph G Martin; Kevin B Cassatt; Katie A Kincaid-Cinnamon; Denise S Westendorf; Ann S Garton; Jon H Lemke Journal: J Arthroplasty Date: 2013-10-16 Impact factor: 4.757
Authors: Sattar Alshryda; James Mason; Praveen Sarda; Antoni Nargol; Nick Cooke; Hafeez Ahmad; S Tang; Raj Logishetty; Manesh Vaghela; Lynne McPartlin; A Pali S Hungin Journal: J Bone Joint Surg Am Date: 2013-11-06 Impact factor: 5.284