Kannan Sridharan1, Gowri Sivaramakrishnan2. 1. Department of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain. 2. School of Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji.
Abstract
BACKGROUND: The present study is a network meta-analysis of various routes of tranexamic acid (TXA) in patients with total hip arthroplasty (THA). METHODS: Randomized controlled trials and cohort studies evaluating TXA in patients with THA were included. Number of patients requiring blood transfusion was the primary outcome. RESULTS: Pooled estimate for TXA use against placebo for blood transfusion rate was 0.30 [0.23, 0.39] favoring TXA. Maximum reduction in the risk of blood transfusion was observed with topical plus intra-operative intravenous TXA. CONCLUSION: Combined topical and intravenous TXA during surgery may perform better than other modes in patients undergoing THA.
BACKGROUND: The present study is a network meta-analysis of various routes of tranexamic acid (TXA) in patients with total hip arthroplasty (THA). METHODS: Randomized controlled trials and cohort studies evaluating TXA in patients with THA were included. Number of patients requiring blood transfusion was the primary outcome. RESULTS: Pooled estimate for TXA use against placebo for blood transfusion rate was 0.30 [0.23, 0.39] favoring TXA. Maximum reduction in the risk of blood transfusion was observed with topical plus intra-operative intravenous TXA. CONCLUSION: Combined topical and intravenous TXA during surgery may perform better than other modes in patients undergoing THA.
Authors: Ian Roberts; Pablo Perel; David Prieto-Merino; Haleema Shakur; Tim Coats; Beverley J Hunt; Fiona Lecky; Karim Brohi; Keith Willett Journal: BMJ Date: 2012-09-11
Authors: Brendan Kleiboer; Marcus A Layer; Lorraine A Cafuir; Adam Cuker; Miguel Escobar; M Elaine Eyster; Eric Kraut; Andrew D Leavitt; Steven R Lentz; Doris Quon; Margaret V Ragni; Dianne Thornhill; Michael Wang; Nigel S Key; Tyler W Buckner Journal: J Thromb Haemost Date: 2022-02-08 Impact factor: 5.824