Literature DB >> 24793893

Topical application of tranexamic acid in primary total hip arthroplasty: a randomized double-blind controlled trial.

Chen Yue1, Pengde Kang1, Peiqing Yang1, Jinwei Xie1, Fuxing Pei1.   

Abstract

So far, studies of topical tranexamic acid (TXA) in total hip arthroplasty (THA) were still lacking and controversial. We conducted this randomized double-blind controlled trial which included 101 patients to assess the effect of a high-dose 3g topical TXA in THA. The results showed that 3g topical TXA could significantly reduce transfusions from 22.4% to 5.7% (P<0.05) without increasing the risk of deep vein thrombosis (DVT), pulmonary embolism (PE) and other complications. In addition, topical TXA significantly reduced total blood loss, reduced drain blood loss, and the drops of HB and HCT in topical TXA group were lower than control group. We concluded that 3g topical TXA was effective and safe in reducing bleeding and transfusions in THA.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  DVT; THA; blood loss; topical; tranexamic acid; transfusions

Mesh：

Substances：

Year:  2014        PMID： 24793893     DOI： 10.1016/j.arth.2014.03.032

Source DB:  PubMed          Journal:  J Arthroplasty        ISSN： 0883-5403            Impact factor:   4.757


  44 in total

1.  Recommendations for the implementation of a Patient Blood Management programme. Application to elective major orthopaedic surgery in adults.

Authors:  Stefania Vaglio; Domenico Prisco; Gianni Biancofiore; Daniela Rafanelli; Paola Antonioli; Michele Lisanti; Lorenzo Andreani; Leonardo Basso; Claudio Velati; Giuliano Grazzini; Giancarlo M Liumbruno
Journal:  Blood Transfus       Date:  2015-12-15       Impact factor: 3.443

Review 2.  Tranexamic acid in total hip arthroplasty: A recursive cumulative meta-analysis of randomized controlled trials and assessment of publication bias.

Authors:  Kannan Sridharan; Gowri Sivaramakrishnan
Journal:  J Orthop       Date:  2017-05-21

3.  Comparing Cost, Efficacy, and Safety of Intravenous and Topical Tranexamic Acid in Total Hip and Knee Arthroplasty.

Authors:  Joseph F DiBlasi; Ross P Smith; Jeffrey Garavaglia; Jeffrey Quedado; Benjamin M Frye; Matthew J Dietz
Journal:  Am J Orthop (Belle Mead NJ)       Date:  2016 Nov/Dec

4.  Matched cohort study of topical tranexamic acid in cementless primary total hip replacement.

Authors:  Javier Sanz-Reig; Jesus Mas Martinez; Carmen Verdu Román; Manuel Morales Santias; Enrique Martínez Gimenez; David Bustamante Suarez de Puga
Journal:  Eur J Orthop Surg Traumatol       Date:  2018-03-29

5.  Topical administration of tranexamic acid in hip arthroplasty.

Authors:  Joon Soon Kang; Kyoung Ho Moon; Bom Soo Kim; Seong Jo Yang
Journal:  Int Orthop       Date:  2016-04-18       Impact factor: 3.075

6.  The efficacy and safety of multiple-dose intravenous tranexamic acid on blood loss following total knee arthroplasty: a randomized controlled trial.

Authors:  Yiting Lei; Jinwei Xie; Bin Xu; Xiaowei Xie; Qiang Huang; Fuxing Pei
Journal:  Int Orthop       Date:  2017-05-31       Impact factor: 3.075

7.  Analysis of a large data set to identify predictors of blood transfusion in primary total hip and knee arthroplasty.

Authors:  ZeYu Huang; Cheng Huang; JinWei Xie; Jun Ma; GuoRui Cao; Qiang Huang; Bin Shen; Virginia Byers Kraus; FuXing Pei
Journal:  Transfusion       Date:  2018-08-25       Impact factor: 3.157

8.  What is the optimal approach for tranexamic acid application in patients with unilateral total hip arthroplasty?

Authors:  Ying Zhang; Leilei Zhang; Xianghao Ma; Yudong Jia; Huichao Wang; Yingjie Zhu; Youwen Liu
Journal:  Orthopade       Date:  2016-07       Impact factor: 1.087

9.  The efficacy and safety of multiple-dose oral tranexamic acid on blood loss following total hip arthroplasty: a randomized controlled trial.

Authors:  Guorui Cao; Qiang Huang; Zeyu Huang; Shaoyun Zhang; Zeyu Luo; Yiting Lei; Zongke Zhou; Fuxing Pei
Journal:  Int Orthop       Date:  2018-04-10       Impact factor: 3.075

10.  Efficacy of topical tranexamic acid within a blood-saving programme for primary total hip arthroplasty: a pragmatic, open-label randomised study.

Authors:  Nuria Pérez-Jimeno; Manuel Muñoz; Jesús Mateo; Ana P Mayoral; Antonio Herrera
Journal:  Blood Transfus       Date:  2018-09-03       Impact factor: 3.443
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