| Literature DB >> 27086067 |
Bo Wang1, Qiyuan Yang1, Corrine L Harris1, Mark L Nelson1, Jan R Busboom1, Mei-Jun Zhu2, Min Du3.
Abstract
To improve the efficiency of animal production, livestock have been extensively selected or managed to reduce fat accumulation and increase lean growth, which reduces intramuscular or marbling fat content. To enhance marbling, a better understanding of the mechanisms regulating adipogenesis is needed. Vitamin A has recently been shown to have a profound impact on all stages of adipogenesis. Retinoic acid, an active metabolite of vitamin A, activates both retinoic acid receptors (RAR) and retinoid X receptors (RXR), inducing epigenetic changes in key regulatory genes governing adipogenesis. Additionally, Vitamin D and folates interact with the retinoic acid receptors to regulate adipogenesis. In this review, we discuss nutritional regulation of adipogenesis, focusing on retinoic acid and its impact on epigenetic modifications of key adipogenic genes.Entities:
Keywords: Adipogenesis; Marbling; Meat; Progenitor cells; Retinoic acid; Vitamin A
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Year: 2016 PMID： 27086067 PMCID： PMC5044758 DOI： 10.1016/j.meatsci.2016.04.003
Source DB: PubMed Journal: Meat Sci ISSN： 0309-1740 Impact factor: 5.209