| Literature DB >> 11463572 |
L Fajas1, M B Debril, J Auwerx.
Abstract
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPAR-gamma has been reported to affect cell proliferation/differentiation pathways in various malignancies. We discuss in the present review recent advances in the understanding of the function of PPAR-gamma in both cell proliferation and adipocyte differentiation.Entities:
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Year: 2001 PMID： 11463572 DOI： 10.1677/jme.0.0270001
Source DB: PubMed Journal: J Mol Endocrinol ISSN： 0952-5041 Impact factor: 5.098