Graham E Quinn1, Charles Barr2, Don Bremer3, Rae Fellows4, Alice Gong5, Robert Hoffman6, Michael X Repka7, Jennifer Shepard7, R Michael Siatkowski8, Kelly Wade9, Gui-Shuang Ying10. 1. Ophthalmology, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address: quinn@email.chop.edu. 2. Department of Ophthalmology, University of Louisville School of Medicine, Louisville, Kentucky. 3. Department of Ophthalmology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio. 4. Department of Ophthalmology, Nationwide Children's Hospital, Columbus, Ohio. 5. University of Texas Health Science Center at San Antonio, San Antonio, Texas. 6. University of Utah, Salt Lake City, Utah. 7. Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. 8. University of Oklahoma Department of Ophthalmology/Dean McGee Eye Institute, Oklahoma City, Oklahoma. 9. Neonatology, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. 10. Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Abstract
PURPOSE: To compare infant and retinopathy of prematurity (ROP) characteristics from 3 clinical studies conducted over a 27-year period in the United States. DESIGN: Secondary analysis of results of 3 clinical studies. PARTICIPANTS: Infants with birth weight (BW) <1251 g. METHODS: Analysis of data from the Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) and Early Treatment for Retinopathy of Prematurity (ETROP) trials and the primary data from the Telemedicine Approaches for the Evaluation of Acute-Phase Retinopathy of Prematurity (e-ROP) study. MAIN OUTCOME MEASURES: Infant characteristics and onset, severity, and time course of ROP. RESULTS: Across the 3 studies, mean (standard deviation) BW and mean gestational age (GA) decreased over time from CRYO-ROP (954 g [185 g], 27.9 weeks [2.2 weeks]) to ETROP (907 g [205 g], 27.4 weeks [2.2 weeks]) to e-ROP (864 g [212 g], 27.0 weeks [2.2 weeks]), with an increase in the percentage of infants enrolled weighing <750 g (15.8% CRYO, 24.9% ETROP, 33.4% e-ROP; P<0.0001). The percentage of infants who developed ROP varied only minimally (65.8% CRYO, 68.0% ETROP, 63.7% e-ROP; P = 0.003). Moderately severe ROP (defined as prethreshold or referral warranted) varied (17.8% CRYO, 12.3% ETROP, 19.4% e-ROP; P<0.0001), whereas the time of onset of any ROP did not vary (34.3 weeks CRYO, 34.1 weeks ETROP, 34.8 weeks e-ROP). CONCLUSIONS: The BW and GA of infants enrolled in ROP studies in the United States have decreased over the past 27 years, whereas ROP prevalence and onset of disease are stable.
PURPOSE: To compare infant and retinopathy of prematurity (ROP) characteristics from 3 clinical studies conducted over a 27-year period in the United States. DESIGN: Secondary analysis of results of 3 clinical studies. PARTICIPANTS: Infants with birth weight (BW) <1251 g. METHODS: Analysis of data from the Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) and Early Treatment for Retinopathy of Prematurity (ETROP) trials and the primary data from the Telemedicine Approaches for the Evaluation of Acute-Phase Retinopathy of Prematurity (e-ROP) study. MAIN OUTCOME MEASURES: Infant characteristics and onset, severity, and time course of ROP. RESULTS: Across the 3 studies, mean (standard deviation) BW and mean gestational age (GA) decreased over time from CRYO-ROP (954 g [185 g], 27.9 weeks [2.2 weeks]) to ETROP (907 g [205 g], 27.4 weeks [2.2 weeks]) to e-ROP (864 g [212 g], 27.0 weeks [2.2 weeks]), with an increase in the percentage of infants enrolled weighing <750 g (15.8% CRYO, 24.9% ETROP, 33.4% e-ROP; P<0.0001). The percentage of infants who developed ROP varied only minimally (65.8% CRYO, 68.0% ETROP, 63.7% e-ROP; P = 0.003). Moderately severe ROP (defined as prethreshold or referral warranted) varied (17.8% CRYO, 12.3% ETROP, 19.4% e-ROP; P<0.0001), whereas the time of onset of any ROP did not vary (34.3 weeks CRYO, 34.1 weeks ETROP, 34.8 weeks e-ROP). CONCLUSIONS: The BW and GA of infants enrolled in ROP studies in the United States have decreased over the past 27 years, whereas ROP prevalence and onset of disease are stable.
Authors: Anna L Ells; Jonathan M Holmes; William F Astle; Geoff Williams; David A Leske; Michael Fielden; Brad Uphill; Penny Jennett; Marilynne Hebert Journal: Ophthalmology Date: 2003-11 Impact factor: 12.079
Authors: Graham E Quinn; Gui-shuang Ying; Ebenezer Daniel; P Lloyd Hildebrand; Anna Ells; Agnieshka Baumritter; Alex R Kemper; Eleanor B Schron; Kelly Wade Journal: JAMA Ophthalmol Date: 2014-10 Impact factor: 7.389
Authors: Graham E Quinn; Gui-Shuang Ying; Edward F Bell; Pamela K Donohue; David Morrison; Lauren A Tomlinson; Gil Binenbaum Journal: JAMA Ophthalmol Date: 2018-12-01 Impact factor: 7.389
Authors: Kelly C Wade; Gui-Shuang Ying; Agnieshka Baumritter; Alice Gong; Alex R Kemper; Graham E Quinn Journal: JAMA Ophthalmol Date: 2019-02-01 Impact factor: 7.389