BACKGROUND: fat infiltration within and around skeletal muscle (i.e. myosteatosis) increases with ageing, is greater in African versus European ancestry men and is associated with poor health. Myosteatosis studies of mortality are lacking, particularly among African ancestry populations. METHODS: in the Tobago Health study, a prospective longitudinal study, we evaluated the association of all-cause mortality with quantitative computed tomography (QCT) measured lower leg myosteatosis (intermuscular fat (IM fat) and muscle density) in 1,652 African ancestry men using Cox proportional hazards models. Date of death was abstracted from death certificates and/or proxy. RESULTS: one hundred and twelve deaths occurred during follow-up (mean 5.9 years). In all men (age range 40-91 years), higher all-cause mortality was associated with greater IM fat (HR (95% CI) per SD: 1.29 (1.06-1.57)) and lower muscle density (HR (95% CI) per SD lower: 1.37 (1.08-1.75)) in fully adjusted models. Similar mortality hazard rates were seen in the subset of elderly men (aged ≥65 years) with greater IM fat (1.40 (1.11-1.78) or lower muscle density (1.66 (1.24-2.21)) in fully adjusted models. CONCLUSIONS: our study identified a novel, independent association between myosteatosis and all-cause mortality in African ancestry men. Further studies are needed to establish whether this association is independent of other ectopic fat depots and to identify possible biological mechanisms underlying this relationship.
BACKGROUND: fat infiltration within and around skeletal muscle (i.e. myosteatosis) increases with ageing, is greater in African versus European ancestry men and is associated with poor health. Myosteatosis studies of mortality are lacking, particularly among African ancestry populations. METHODS: in the Tobago Health study, a prospective longitudinal study, we evaluated the association of all-cause mortality with quantitative computed tomography (QCT) measured lower leg myosteatosis (intermuscular fat (IM fat) and muscle density) in 1,652 African ancestry men using Cox proportional hazards models. Date of death was abstracted from death certificates and/or proxy. RESULTS: one hundred and twelve deaths occurred during follow-up (mean 5.9 years). In all men (age range 40-91 years), higher all-cause mortality was associated with greater IM fat (HR (95% CI) per SD: 1.29 (1.06-1.57)) and lower muscle density (HR (95% CI) per SD lower: 1.37 (1.08-1.75)) in fully adjusted models. Similar mortality hazard rates were seen in the subset of elderly men (aged ≥65 years) with greater IM fat (1.40 (1.11-1.78) or lower muscle density (1.66 (1.24-2.21)) in fully adjusted models. CONCLUSIONS: our study identified a novel, independent association between myosteatosis and all-cause mortality in African ancestry men. Further studies are needed to establish whether this association is independent of other ectopic fat depots and to identify possible biological mechanisms underlying this relationship.
Authors: E M Simonsick; C E Maffeo; S K Rogers; E A Skinner; D Davis; J M Guralnik; L P Fried Journal: J Gerontol A Biol Sci Med Sci Date: 1997-09 Impact factor: 6.053
Authors: D Enette Larson-Meyer; Steven R Smith; Leonie K Heilbronn; David E Kelley; Eric Ravussin; Bradley R Newcomer Journal: Obesity (Silver Spring) Date: 2006-01 Impact factor: 5.002
Authors: James R Cerhan; Steven C Moore; Eric J Jacobs; Cari M Kitahara; Philip S Rosenberg; Hans-Olov Adami; Jon O Ebbert; Dallas R English; Susan M Gapstur; Graham G Giles; Pamela L Horn-Ross; Yikyung Park; Alpa V Patel; Kim Robien; Elisabete Weiderpass; Walter C Willett; Alicja Wolk; Anne Zeleniuch-Jacquotte; Patricia Hartge; Leslie Bernstein; Amy Berrington de Gonzalez Journal: Mayo Clin Proc Date: 2014-03 Impact factor: 7.616
Authors: Bret H Goodpaster; Seok Won Park; Tamara B Harris; Steven B Kritchevsky; Michael Nevitt; Ann V Schwartz; Eleanor M Simonsick; Frances A Tylavsky; Marjolein Visser; Anne B Newman Journal: J Gerontol A Biol Sci Med Sci Date: 2006-10 Impact factor: 6.053
Authors: Iva Miljkovic; Jane A Cauley; Patty Y Wang; Kathleen F Holton; Christine G Lee; Yahtyng Sheu; Elizabeth Barrett-Connor; Andrew R Hoffman; Cora B Lewis; Eric S Orwoll; Marcia L Stefanick; Elsa S Strotmeyer; Lynn M Marshall Journal: Obesity (Silver Spring) Date: 2013-05-29 Impact factor: 5.002
Authors: Mariana Murea; Leon Lenchik; Thomas C Register; Gregory B Russell; Jianzhao Xu; S Carrie Smith; Donald W Bowden; Jasmin Divers; Barry I Freedman Journal: J Diabetes Complications Date: 2018-03-19 Impact factor: 2.852
Authors: Leon Lenchik; Ryan Barnard; Robert D Boutin; Stephen B Kritchevsky; Haiying Chen; Josh Tan; Peggy M Cawthon; Ashley A Weaver; Fang-Chi Hsu Journal: J Gerontol A Biol Sci Med Sci Date: 2021-01-18 Impact factor: 6.053
Authors: Allison L Kuipers; Joseph M Zmuda; J Jeffrey Carr; James G Terry; Sangeeta Nair; Ryan Cvejkus; Clareann H Bunker; Alan L Patrick; Christina L Wassel; Iva Miljkovic Journal: Atherosclerosis Date: 2017-06-16 Impact factor: 5.162
Authors: Joshua F Baker; Sogol Mostoufi-Moab; Jin Long; Babette Zemel; Said Ibrahim; Elena Taratuta; Mary B Leonard Journal: Arthritis Care Res (Hoboken) Date: 2018-11-02 Impact factor: 4.794
Authors: Carla M Prado; Sarah A Purcell; Carolyn Alish; Suzette L Pereira; Nicolaas E Deutz; Daren K Heyland; Bret H Goodpaster; Kelly A Tappenden; Steven B Heymsfield Journal: Ann Med Date: 2018-09-12 Impact factor: 4.709
Authors: Joshua F Baker; Sogol Mostoufi-Moab; Jin Long; Elena Taratuta; Mary B Leonard; Babette Zemel Journal: Arthritis Care Res (Hoboken) Date: 2021-03 Impact factor: 4.794
Authors: Thomas Pacicco; Shayna Ratner; Yin Xi; Takeshi Yokoo; David Fetzer; Orhan K Oz; Craig D Rubin; Avneesh Chhabra Journal: Indian J Radiol Imaging Date: 2019 Apr-Jun