Literature DB >> 270708

Immunological distinction between acetylcholine receptor and the alpha-bungarotoxin-binding component on sympathetic neurons.

J Patrick, W B Stallcup.   

Abstract

Clone PC12 of a rat sympathetic neuron cell line binds alpha-bungarotoxin and exhibits carbamoylcholine-stimulated uptake of sodium ions. Concentrations of alpha-bungarotoxin that saturate the alpha-bungarotoxin-binding site have no effect on agonist-stimulated sodium uptake. Conversely, antibodies against eel acetylcholine receptor block the agonist-induced sodium flux but fail to recognize the alpha-bungarotoxin-binding component. Detergent extracts of the PC12 clone inhibit the ability of antibody to eel acetylcholine receptor to recognize 125I-alpha-bungarotoxin-acetylcholine receptor complexes derived from muscle. These results distinguish between a ganglionic nicotinic acetylcholine receptor and an alpha-bungarotoxin-binding component on these cells, and provide evidence for antigenic similarities between muscle acetylcholine receptor and ganglionic acetylcholine receptor.

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Year:  1977        PMID： 270708      PMCID： PMC432013          DOI： 10.1073/pnas.74.10.4689

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  Cholinergic metabolism and synapse formation by a rat nerve cell line.

Authors:  D Schubert; S Heinemann; Y Kidokoro
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

2.  -Bungarotoxin used as a probe for acetylcholine receptors of cultured neurones.

Authors:  L A Greene; A J Sytkowski; Z Vogel; M W Nirenberg
Journal:  Nature       Date:  1973-05-18       Impact factor: 49.962

3.  Effect of whole and fractionated cobra venom on sympathetic ganglionic transmission.

Authors:  T C Chou; C Y Lee
Journal:  Eur J Pharmacol       Date:  1969-12       Impact factor: 4.432

4.  Studies on purified eel acetylcholine receptor and anti-acetylcholine receptor antibody.

Authors:  J Patrick; J Lindstrom; B Culp; J McMillan
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

5.  Development of acetylcholine receptor clusters on cultured muscle cells.

Authors:  A J Sytkowski; Z Vogel; M W Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1973-01       Impact factor: 11.205

6.  Acetylcholine receptors of muscle grown in vitro.

Authors:  Z Vogel; A J Sytkowski; M W Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1972-11       Impact factor: 11.205

7.  Acetylcholine receptor metabolism in a nonfusing muscle cell line.

Authors:  J Patrick; J McMillan; H Wolfson; J C O'Brien
Journal:  J Biol Chem       Date:  1977-03-25       Impact factor: 5.157

8.  Immunological characterisation of the cholinergic receptor protein from Electrophorus electricus.

Authors:  H Sugiyama; P Benda; J C Meunier; J P Changeux
Journal:  FEBS Lett       Date:  1973-09-01       Impact factor: 4.124

9.  Clonal cell lines from the rat central nervous system.

Authors:  D Schubert; S Heinemann; W Carlisle; H Tarikas; B Kimes; J Patrick; J H Steinbach; W Culp; B L Brandt
Journal:  Nature       Date:  1974-05-17       Impact factor: 49.962

10.  Modulation of acetylcholine receptor by antibody against the receptor.

Authors:  S Heinemann; S Bevan; R Kullberg; J Lindstrom; J Rice
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205
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  35 in total

1.  Rectification of acetylcholine-elicited currents in PC12 pheochromocytoma cells.

Authors:  C K Ifune; J H Steinbach
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

2.  alpha-Bungarotoxin blocks nicotinic transmission in the avian ciliary ganglion.

Authors:  V A Chiappinelli; R E Zigmond
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

3.  Detection of functional nicotinic receptors blocked by alpha-bungarotoxin on PC12 cells and dependence of their expression on post-translational events.

Authors:  E M Blumenthal; W G Conroy; S J Romano; P D Kassner; D K Berg
Journal:  J Neurosci       Date:  1997-08-15       Impact factor: 6.167

Review 4.  Regulation of nicotinic acetylcholine receptors by protein phosphorylation.

Authors:  K Miles; R L Huganir
Journal:  Mol Neurobiol       Date:  1988       Impact factor: 5.590

Review 5.  Molecular studies of the neuronal nicotinic acetylcholine receptor family.

Authors:  J Lindstrom; R Schoepfer; P Whiting
Journal:  Mol Neurobiol       Date:  1987       Impact factor: 5.590

6.  Mapping of brain areas expressing RNA homologous to two different acetylcholine receptor alpha-subunit cDNAs.

Authors:  D Goldman; D Simmons; L W Swanson; J Patrick; S Heinemann
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

7.  Pathogenesis of myasthenia gravis. Acetylcholine receptor-related antigenic determinants in tumor-free thymuses and thymic epithelial tumors.

Authors:  T Kirchner; S Tzartos; F Hoppe; B Schalke; H Wekerle; H K Müller-Hermelink
Journal:  Am J Pathol       Date:  1988-02       Impact factor: 4.307

8.  Cyclic AMP regulates the proportion of functional acetylcholine receptors on chicken ciliary ganglion neurons.

Authors:  J F Margiotta; D K Berg; V E Dionne
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

9.  Cocaine and phencyclidine inhibition of the acetylcholine receptor: analysis of the mechanisms of action based on measurements of ion flux in the millisecond-to-minute time region.

Authors:  J W Karpen; H Aoshima; L G Abood; G P Hess
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

10.  Sodium and calcium fluxes in a clonal nerve cell line.

Authors:  W B Stallcup
Journal:  J Physiol       Date:  1979-01       Impact factor: 5.182
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