Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cholinergic metabolism and synapse formation by a rat nerve cell line.

Literature DB >> 196294

Cholinergic metabolism and synapse formation by a rat nerve cell line.

Abstract

The PC12 clone of a rat pheochromocytoma is able to synthesize acetylcholine. The amount of acetylcholine synthesized, and the specific activity of choline O-acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6), varies as a function of the culture growth curve and is dependent on cell density. The specific activity of choline acetyltransferase is increased by nerve growth factor, growth-conditioned medium from a variety of cell types, and adenosine 3':5'-monophosphate. Finally, the PC12 cell line is able to form cholinergic synapses with a clonal cell line of skeletal muscle origin.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1977 PMID： 196294 PMCID： PMC432217 DOI： 10.1073/pnas.74.6.2579

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

35 in total

1. Steps in the neoplastic transformation of hamster embryo cells by polyoma virus.

Authors: M VOGT; R DULBECCO
Journal: Proc Natl Acad Sci U S A Date: 1963-02-15 Impact factor: 11.205

2. Identification and characterization of multiple forms of actin.

Authors: J I Garrels; W Gibson
Journal: Cell Date: 1976-12 Impact factor: 41.582

3. Biochemical studies on the development of primary sympathetic neurons in cell culture.

Authors: P H Patterson; L F Reichardt; L L Chun
Journal: Cold Spring Harb Symp Quant Biol Date: 1976

4. Cell density dependent regulation of phenylalanine hydroxylase activity in hepatoma cells. Evidence for both an active and inactive enzyme form.

Authors: D McClure; M R Miller; R Shiman
Journal: Exp Cell Res Date: 1976-03-15 Impact factor: 3.905

5. Synaptic vesicle cytochemistry changes when cultured sympathetic neurones develop cholinergic interactions.

Authors: M Johnson; D Ross; M Meyers; R Rees; R Bunge; E Wakshull; H Burton
Journal: Nature Date: 1976-07-22 Impact factor: 49.962

6. Central nervous system synapses in cell culture.

Authors: P G Nelson
Journal: Cold Spring Harb Symp Quant Biol Date: 1976

7. Properties of a clonal muscle cell line from rat heart.

Authors: B W Kimes; B L Brandt
Journal: Exp Cell Res Date: 1976-03-15 Impact factor: 3.905

8. Synapse formation between clonal neuroblastoma X glioma hybrid cells and striated muscle cells.

Authors: P Nelson; C Christian; M Nirenberg
Journal: Proc Natl Acad Sci U S A Date: 1976-01 Impact factor: 11.205

9. Rat sympathetic neurons and cardiac myocytes developing in microcultures: correlation of the fine structure of endings with neurotransmitter function in single neurons.

Authors: S C Landis
Journal: Proc Natl Acad Sci U S A Date: 1976-11 Impact factor: 11.205

10. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

Authors: L A Greene; A S Tischler
Journal: Proc Natl Acad Sci U S A Date: 1976-07 Impact factor: 11.205

47 in total

1. Exocytosis and endocytosis of small vesicles in PC12 cells studied with TEPIQ (two-photon extracellular polar-tracer imaging-based quantification) analysis.

Authors: Ting-Ting Liu; Takuya Kishimoto; Hiroyasu Hatakeyama; Tomomi Nemoto; Noriko Takahashi; Haruo Kasai
Journal: J Physiol Date: 2005-09-08 Impact factor: 5.182

6. Distinct signalling pathways mediate the cAMP response element (CRE)-dependent activation of the calcitonin gene-related peptide gene promoter by cAMP and nerve growth factor.

Authors: K Freeland; Y Z Liu; D S Latchman
Journal: Biochem J Date: 2000-01-15 Impact factor: 3.857

10. Differentiation and transdifferentiation of adrenal chromaffin cells of the guinea pig. II. Adrenal medullary explants grown in tissue culture.

Authors: K Unsicker
Journal: Cell Tissue Res Date: 1981 Impact factor: 5.249

Cholinergic metabolism and synapse formation by a rat nerve cell line.

1. Steps in the neoplastic transformation of hamster embryo cells by polyoma virus.

2. Identification and characterization of multiple forms of actin.

3. Biochemical studies on the development of primary sympathetic neurons in cell culture.

4. Cell density dependent regulation of phenylalanine hydroxylase activity in hepatoma cells. Evidence for both an active and inactive enzyme form.

5. Synaptic vesicle cytochemistry changes when cultured sympathetic neurones develop cholinergic interactions.

6. Central nervous system synapses in cell culture.

7. Properties of a clonal muscle cell line from rat heart.

8. Synapse formation between clonal neuroblastoma X glioma hybrid cells and striated muscle cells.

9. Rat sympathetic neurons and cardiac myocytes developing in microcultures: correlation of the fine structure of endings with neurotransmitter function in single neurons.

10. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1. Exocytosis and endocytosis of small vesicles in PC12 cells studied with TEPIQ (two-photon extracellular polar-tracer imaging-based quantification) analysis.

2. Alteration of cellular adhesion by nerve growth factor.

3. Dp71, utrophin and beta-dystroglycan expression and distribution in PC12/L6 cell cocultures.

4. Herpes simplex virus replication in pheochromocytoma cell line that responds to nerve growth factor.

5. The reverse transforming effects of nerve growth factor on five human neurogenic tumor cell lines: in vitro results.

6. Distinct signalling pathways mediate the cAMP response element (CRE)-dependent activation of the calcitonin gene-related peptide gene promoter by cAMP and nerve growth factor.

7. Storage and release of acetylcholine by a clonal cell line.

8. Sodium and calcium fluxes in a clonal nerve cell line.

9. Catecholamine secretion in a rat pheochromocytoma cell line: two pathways for calcium entry.

10. Differentiation and transdifferentiation of adrenal chromaffin cells of the guinea pig. II. Adrenal medullary explants grown in tissue culture.