Methicillin-resistant Staphylococcus aureus nosocomial pneumonia: role of linezolid in the People's Republic of China.

The burden of methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia in the People's Republic of China is high, with methicillin-resistance rates greater than 80% reported for patients with S. aureus pneumonia treated in intensive care units. Historically, vancomycin was the treatment of choice for patients with hospital-acquired MRSA infections. Recent evidence suggests that the minimum inhibitory concentration for vancomycin is increasing. Additionally, patients treated with vancomycin require monitoring of vancomycin trough concentrations and can develop nephrotoxicity. Linezolid is a treatment option for patients with hospital-acquired MRSA infections that can be administered either intravenously or orally. Analysis of data from a worldwide linezolid surveillance program initiated in the year 2004 shows no evidence of increasing linezolid minimum inhibitory concentrations. The clinical efficacy of linezolid for patients with gram-positive, including MRSA, nosocomial pneumonia, was evaluated in numerous studies. In general, results from these studies show higher or similar clinical success with no mortality difference for linezolid compared to vancomycin treated patients. Results from a Phase IV study enrolling patients with MRSA-confirmed nosocomial pneumonia suggest higher clinical cure rates for linezolid compared to vancomycin treated patients. Although acquisition costs are higher for linezolid compared to vancomycin therapy, evidence suggests similar overall medical costs. Cost-analysis results from a Chinese perspective show that linezolid dominated vancomycin therapy for MRSA nosocomial pneumonia in ∼35% of bootstrap simulations whereas vancomycin dominated linezolid in less than 2% of bootstrap simulations. In summary, results from both clinical and economic studies, including studies conducted from a Chinese perspective, support the use of linezolid for the treatment of patients with MRSA nosocomial pneumonia.

Introduction

Globally, antibacterial resistance negatively affects patient outcomes and health care costs.1 The ability to treat many common health care- and community-associated infections is threatened by the development of resistant bacteria.1 Staphylococcus aureus is an example of a pathogenic, gram-positive organism that over time developed resistance to many available antibiotics, including penicillin and beta-lactamase stable penicillins such as methicillin and oxacillin.

S. aureus is frequently found on the skin and in the nose and is a common cause of skin and soft tissue, bone, bloodstream, and postoperative wound infections. The percentage of S. aureus resistant to methicillin is greater than 20% in many geographical regions and exceeds 80% in some World Health Organization regions.1 Evidence suggests an increasing role of methicillin-resistant S. aureus (MRSA) in patients with hospital-acquired pneumonia (HAP).2 Results from several studies specific to the People’s Republic of China or the Asia region show that S. aureus plays a major role in patients with HAP, including ventilator associated pneumonia (VAP).3–5 Results from a systematic review and meta-analysis show that S. aureus is the fourth most frequently isolated pathogen, and 82.9% of S. aureus isolates were methicillin-resistant in patients with ICU-acquired pneumonia or VAP in the People’s Republic of China.5 Whereas community-acquired S. aureus strains tend to maintain sensitivity to non-beta-lactam antibiotics such as clindamycin and trimethoprim/sulfamethoxazole, hospital-acquired strains are often multidrug-resistant3,5–7 with few treatment options.

Vancomycin and linezolid are treatment options for patients with gram-positive infections including those caused by MRSA. Results from a published Phase IV trial (Zyvox® in the Treatment of Subjects with Nosocomial Pneumonia Proven to be Due to Methicillin-Resistant Staphylococcus aureus [ZEPHyR]) suggest higher clinical success and similar mortality in patients with MRSA nosocomial pneumonia treated with linezolid compared to vancomycin therapy.8 Although acquisition costs are higher for linezolid than vancomycin, analysis of health care resource utilization from a Chinese perspective using outcomes data from the ZEPHyR trial found no difference in overall medical costs between linezolid and vancomycin treated patients.9 Results from a multicenter, retrospective, observational study similarly show higher clinical success and similar mortality in patients with MRSA nosocomial pneumonia treated with linezolid compared to vancomycin therapy.10 In contrast, results from a retrospective study conducted in the People’s Republic of China show similar clinical success but higher mortality in patients empirically treated with linezolid compared to vancomycin for HAP; total hospital costs trended lower for vancomycin compared to linezolid treated patients although this difference was not significant.11 The objective of this review is to summarize the available clinical and economic information on the treatment of MRSA nosocomial pneumonia with a focus on linezolid and vancomycin as well as economic and clinical data available for the People’s Republic of China.

Methods

A PubMed search was performed to identify studies reporting the incidence of MRSA in the People’s Republic of China for the years 2004 through 2014. Of the 179 citations identified, ten studies reported incidence data for MRSA isolates in the People’s Republic of China.6,7,12–19 A PubMed search was also performed to identify comparative studies and meta-analyses evaluating linezolid and vancomycin therapy in adult patients with nosocomial pneumonia. Of the 35 citations identified, 24 studies or meta-analyses8,10,11,31–51 compared the economic or clinical outcome of patients treated with either linezolid or vancomycin therapy and were included in this review. An additional economic study was identified through a Google search.9

MRSA incidence in the People’s Republic of China

Overall

Results from studies conducted throughout the People’s Republic of China from the year 2004 through the year 2011 suggest that the burden of MRSA is high, ranging from ∼27% to 65% (Table 1).6,7,12–19 Analysis of S. aureus resistance in Chinese cities shows considerable variability ranging from a low of less than 40% at Beijing Union Medical College Hospital and Sir Run Run Shaw Hospital of Zhejiang University Medical College to a high of more than 80% at Beijing Hospital.20

Table 1

Summary of results for studies reporting Staphylococcus aureus resistance to methicillin in the People’s Republic of China

Reference	Chinese sites, n	Date isolates obtained	Infection type	S. aureus
				Isolates, n	MR isolates, n (%)
Chen et al12	4	2009–2011	BS	108	62 (57.4)
Chen et al6,a	13	2011	BS, HAP, IA	NR	NR (64.4)
Jones et al13	12	2011	BS, RT, SSS	343	157 (45.8)
Lu et al14,a	18	2007–2008	BS	37	20 (54.1)
		2009–2010		170	62 (36.5)
Reinert et al15	2	2004–2006	Various	NR	NR (59.1)
Sun et al16,a	12	2009	NR	466	211 (45.3)
Wang et al17	16	2008	NR	798	403 (50.5)
Wei et al18	1	2008–2011	Various	690	391 (56.7)
Zhao et al7	12	2005–2010	Various	2,245	1,050 (46.8)
			Respiratory	735	496 (67.5)
			SSS	771	211 (27.4)
Zou et al19	11	2006–2008	Various	293	190 (64.8)

Notes:

Data taken from abstract; article in Chinese.

Abbreviations: BS, bloodstream; HAP, hospital-acquired pneumonia; IA, intra-abdominal; MR, methicillin-resistant; NR, not reported; RT, respiratory tract; SSS, skin and skin structure.

Nosocomial pneumonia

The prevalence of MRSA in the People’s Republic of China may be higher in patients with respiratory than other types of infections.3,5–7 Results from a meta-analysis and systematic review of studies published between January 2007 and May 2012 show that S. aureus was the fourth most common cause of pneumonia in patients hospitalized in intensive care units in the People’s Republic of China; 82.9% of S. aureus isolates were methicillin-resistant.5 Results from a prospective surveillance study conducted in ten Asian countries by the Asian Network Surveillance of Resistant Pathogens (ANSORP) group for the years 2008 to 2009 were similar.3 For the ten Asian locales included in this study, S. aureus was the most common cause of HAP accounting for 15.8% of all HAP cases and the third most common cause of VAP accounting for 12.2% of all VAP cases; 82.1% of S. aureus isolates were resistant to methicillin. Analysis of data from the People’s Republic of China only found that S. aureus was the second most common cause of HAP accounting for 16.0% of all HAP cases and the third most common cause of VAP accounting for 24% of all VAP cases; 82.4% of isolates were resistant to methicillin. Lastly, results from a prospective multicenter study performed in 13 Chinese urban tertiary hospitals showed that S. aureus was the third most common cause of HAP accounting for 13.4% of all HAP cases, and the second most common cause of VAP accounting for 21.4% of all VAP cases; 87.8% of isolates were resistant to methicillin.4

MRSA pneumonia treatment

Treatment recommendations

Recommendations for the treatment of HAP22 and S. aureus nosocomial pneumonia23 for the Asia region are available in the medical literature. These guidelines account for not only differences in HAP epidemiology and microbiology but also the use, availability, and cost of antibiotic therapies between the Asia region and those covered by other published guidelines such as the US24,25 and England.26

Asian HAP Working Group

The Asian HAP Working Group published treatment recommendations for patients with HAP in Asian countries in the year 2008.22 These guidelines state that inclusion of glycopeptide or linezolid therapy is a matter of clinical judgment and local sensitivity profiles but should be considered for patients with late-onset HAP or early- or late-onset VAP. Vancomycin and teicoplanin are the recommended first-line therapies; linezolid and tigecycline are the recommended second-line therapies. The working group suggested reserving linezolid for second-line MRSA therapy to avoid selection of resistant strains.

Asian Consensus Taskforce on MRSA Nosocomial Pneumonia

More recently, the Asian Consensus Taskforce on MRSA Nosocomial Pneumonia published treatment recommendations in the year 2014 to provide clinicians guidance on treating adult patients with MRSA nosocomial pneumonia in Asia taking into account regional data on MRSA colonization and vancomycin minimum inhibitory concentrations (MICs).23 These recommendations stress the importance of timely appropriate antibiotic therapy with either linezolid or vancomycin for patients with suspected MRSA nosocomial pneumonia. Linezolid is recommended for patients with a high risk of vancomycin failure or intolerance defined as the following: prevailing local vancomycin MIC of 1.5 mg/L or greater, age of 65 years or greater, reduced renal function, concurrent administration of nephrotoxic drugs, body mass index greater than 30 kg/m2, or prior vancomycin therapy. Vancomycin is recommended for patients not at risk of vancomycin failure or intolerance.

Treatments

Vancomycin

Vancomycin, a glycopeptide antibiotic, traditionally was the treatment of choice for patients with MRSA infections including MRSA pneumonia. Recent evidence suggests, however, that the vancomycin MIC for staphylococci is increasing which may ultimately result in an increase in vancomycin-resistant staphylococci.27 Results from a study conducted in six Chinese hospitals suggest that the vancomycin MIC for MRSA isolates is increasing. For the years 2006 to 2011, the MIC for vancomycin significantly increased over time from 0.906 to 1.040 mg/L (P<0.001 for trend). Likewise, the percentage of MRSA with a vancomycin MIC greater than 1 mg/L increased from 26.0% in the year 2006 to 42.8% in the year 2011 (P<0.005). The probability of achieving optimal vancomycin concentrations when the MIC is greater than 1 mg/L at a vancomycin dose of 0.5 to 2 g every 12 hours is unlikely.23 A creep in the MIC for teicoplanin was also reported increasing from 0.749 mg/L in the year 2009 to 0.973 mg/L in the year 2011.

Other disadvantages of vancomycin therapy include slow bactericidal activity, minimal penetration into lung tissue, and nephrotoxicity.23 Current recommendations for patients with nosocomial pneumonia are to achieve vancomycin trough concentrations of 15 to 20 mg/L to maximize pharmacokinetic and pharmacodynamic properties.28 Nephrotoxicity with vancomycin therapy appears to increase with trough concentrations greater than 10 mg/L, especially in patients receiving concurrent nephrotoxic therapies.28

Linezolid

Linezolid is a synthetic oxazolidione antibacterial agent indicated for the treatment of vancomycin-resistant Enterococcus faecium infections, complicated and uncomplicated skin and soft tissue infections caused by methicillin sensitive S. aureus (MSSA) or Streptococcus pyogenes, complicated skin and soft tissue infections caused by MRSA or Streptococcus agalactiae, and nosocomial pneumonia caused by MRSA, MSSA, or Streptococcus pneumonia including multidrug-resistant strains. Linezolid is available in both an intravenous and oral form; the oral form is 100% bioavailable allowing for a seamless transition from intravenous to oral therapy. Hematologic toxicity can occur with linezolid therapy; however, this typically occurs with long-term administration.

Linezolid activity against gram-positive organisms is monitored through the Zyvox® Annual Appraisal of Potency and Spectrum (ZAAPS) program, with data obtained from 73 medical centers in 33 countries (not including the US) from five continents and available for the years 2004 through 2013. Since inception of this worldwide surveillance program, linezolid susceptibility remains greater than 99.9% with no evidence of MIC creep.29,30

Clinical evidence, linezolid versus vancomycin

ZEPHyR trial

The objective of the ZEPHyR trial was to compare the efficacy, safety, and tolerability of linezolid (n=172) compared to vancomycin (n=176) therapy in adult patients with culture-proven MRSA nosocomial pneumonia.8 This multinational, prospective, randomized, double-blind, multicenter study randomized patients to either intravenous linezolid 600 mg every 12 hours or intravenous vancomycin 15 mg/kg every 12 hours for 7 to 14 consecutive days. Vancomycin dosing was adjusted based on renal function and trough concentrations.

More patients treated with linezolid (n=95, 57.6%) compared to vancomycin (n=81, 46.6%) were clinically cured at end of study (P=0.042). In general, clinical success rates were 10% to 15% higher in linezolid compared to vancomycin treated patients in most populations and subgroups evaluated including patients with a vancomyin MIC of 1 μg/mL (61.5% vs 47.8%; 95% confidence interval [CI] for difference, 1.6–25.8) and APACHE II score <20 (61.6% vs 48.8%; 95% CI for difference, 0.2–25.5). Microbiological success (either eradication or presumed eradication) was also greater in linezolid than vancomycin treated patients at both end of study (58.1% vs 47.1%; 95% CI: 0.4–21.5) and end of treatment (81.9% vs 60.6%; 95% CI: 12.3–30.2) suggesting that MRSA clearance may be more complete with linezolid than vancomycin therapy.

In the intent to treat population, investigator-reported renal events defined as one or more of the following: renal failure, renal impairment, and azotemia, were two times more common in vancomycin (7.3%) compared to linezolid (3.7%) treated patients.8 Investigator-reported rates of anemia, neutropenia, and thrombocytopenia were similar between the linezolid and vancomycin groups.

All-cause, 60-day mortality in both the intent to treat and modified intent to treat populations was similar between the linezolid (15.7%) and vancomycin (17.0%) treatment groups.

Phase III and other sponsor supported randomized trials

Two additional sponsor supported studies were conducted in adult patients with nosocomial pneumonia.31,32 Both of these studies were randomized, double-blind registration studies that compared linezolid with vancomycin for the empiric treatment of nosocomial pneumonia. Patients were randomly assigned to receive either linezolid 600 mg intravenously every 12 hours or vancomycin 1,000 mg intravenously every 12 hours (dose adjusted per an unblinded investigator). Aztreonam therapy was permitted in both treatment groups for gram-negative coverage.

Results from both studies show similar clinical cure and pathogen eradication rates for linezolid and vancomycin treated patients (Table 2). Secondary efficacy outcomes evaluated such as clinical signs and symptoms of pneumonia, chest radiograph, temperature, respiratory rate, and white blood cell count were also similar between the treatment groups. There were no significant differences in the number of deaths between the treatment groups in either study.

Table 2

Clinical cure and organism eradication rates for linezolid and vancomycin treatment groups in randomized studies enrolling patients with known or suspected gram-positive nosocomial pneumoniaa

Population or subgroup	Patients, n/N (%)b		95% CI for differencec
	Linezolid	Vancomycin
Rubinstein et al31
Clinical cure
ITT	86/161 (53.4)	74/142 (52.1)	NR
CEa	71/107 (66.4)	62/91 (68.1)	−14.9 to 11.3
MEb	36/53 (67.9)	28/39 (71.8)	−22.8 to 15.0
Organism eradication
Staphylococcus aureus	25/41 (61.0)	15/23 (65.2)	NR
MR S. aureus	15/23 (60.9)	7/9 (77.8)	NR
Streptococcus pneumoniae	9/9 (100)	9/9 (100)	NR
Wunderink et al33
Clinical cure
ITT	135/256 (52.7)	128/245 (43.5)	−8.3 to 9.2
CEa	114/168 (67.9)	111/171 (43.5)	−7.1 to 13.0
ME	47/76 (61.8)	42/78 (92.3)	−6.9 to 24.2
Organism eradication
S. aureus	28/52 (53.8)	27/62 (43.5)	−8.0 to 28.6
MR S. aureus	12/19 (63.2)	10/23 (43.5)	NR
S. pneumoniae	14/18 (77.8)	12/13 (92.3)	−38.6 to 9.5
Lin et al35
Effective treatment rate
EOT	22/28 (78.6)	18/34 (52.9)	2.99 to 48.3
FU	19/26 (73.1)	18/33 (54.5)	−5.5 to 42.6
Pathogen eradication rate
Gram-positive pneumonia	17/22 (77.3)	15/28 (53.6)	−1.75 to 49.16
S. aureus	14/18 (77.8)	11/21 (52.4)	NR

Notes:

Only data presented for patients with known or suspected gram-positive pneumonia;

data presented as n/N where n equals the number of patients with a response and N equals the number of patients evaluated;

CI for difference between clinical success rates for linezolid minus those for vancomycin.

Abbreviations: CI, confidence interval; CE, clinically evaluable; EOT, end of treatment; FU, follow-up; ITT, intent to treat; ME, microbiologically evaluable; MR, methicillin-resistant; NR, not reported.

In contrast to the ZEPHyR study in which enrolled patients had culture proven MRSA pneumonia, patients were enrolled in these Phase III studies for the empiric treatment of nosocomial pneumonia. Approximately 30% to 35% of patients had a gram-positive organism identified at baseline; an additional 8% to 13% of patients had both a gram-positive and gram-negative organism identified at baseline. Data for patients with S. aureus pneumonia were retrospectively combined and analyzed.33 Results from this combined analysis showed a significantly higher clinical cure rate for linezolid (36 of 61 patients; 59.0%) compared to vancomycin (22 of 62 patients; 35.5%) treated patients with MRSA-confirmed nosocomial pneumonia (P<0.01); this difference remained significant following adjustment for differences in patient characteristics at baseline (odds ratio [OR], 3.3; 95% CI, 1.3–8.3; P=0.01). Kaplan–Meier analyses showed a survival difference for linezolid (80%) compared to vancomycin (63.5%) therapy in patients with MRSA pneumonia (P=0.03) which remained significant after adjusting for baseline variables (OR, 2.2; 95% CI, 1.0–4.8; P=0.01).

A second retrospective analysis evaluated data from these two Phase III trials for patients with suspected gram-positive VAP (N=544); 91 patients had documented MRSA VAP.34 Clinical cure rates and hospital survival were higher for linezolid compared to vancomycin therapy for all populations evaluated. Results from logistic regression analyses showed that linezolid therapy was a significant predictor of clinical cure and hospital survival for all four populations evaluated.

A randomized, double-blind, Phase III study comparing linezolid and vancomycin therapy in patients with gram-positive infections was also performed at seven hospitals in the People’s Republic of China.35 Patients enrolled had known or suspected gram-positive pneumonia or complicated skin and soft-tissue infections. Overall, S. aureus was the most common organism isolated at baseline; 75% of S. aureus isolated were resistant to methicillin. Results are summarized for patients with pneumonia only. At end of treatment and at the follow-up visit (7 to 28 days post-treatment), clinical cure rates were higher for patients treated with linezolid than vancomycin; microbiological eradication was also higher for patients treated with linezolid compared to vancomycin (Table 2).

Lastly, two additional sponsor supported studies randomized patients to linezolid or vancomycin therapy for treatment of known or suspected MRSA infections including patients with known or suspected MRSA pneumonia36 or MRSA VAP.37 In the known or suspected MRSA infection study,36 there was no difference in clinical cure rate (56.8% vs 55.0%; P=0.74; 95% CI for difference −8.5 to 12.0) or microbiological success rate (50.8% vs 51.7%; P=0.90; 95% CI for difference −13.4 to 11.7) between linezolid and vancomycin treated patients overall. In the MRSA VAP study,37 numerically more patients treated with linezolid than vancomycin achieved microbiologic (56.5% vs 47.4%; P=0.757; 95% CI −21.1 to 39.4) and clinical (66.7% vs 52.9%; P-value not reported) cures. Additionally, more patients treated with linezolid than vancomycin survived (86.7% vs 70.0%).

Retrospective analyses

Four studies retrospectively compared clinical outcomes in patients with MRSA pneumonia10,11,38,39 including two studies that compared outcomes in patients with MRSA VAP.10,39 Results from a retrospective analysis of data in the US Veterans Health Administration national database (January 1, 2002 to September 30, 2010) reflecting real-world clinical settings found a significantly higher clinical success rate in linezolid (n=231) than vancomycin (n=3,500) treated patients (adjusted hazard ratio, 1.25; CI, 1.07–1.47) with MRSA pneumonia.38 Thirty-day mortality was similar between linezolid (19.5%) and vancomycin (20.9%) treated patients (P=0.56). In contrast, results from a retrospective study using a hospital database from a tertiary care hospital in Shanghai, People’s Republic of China, showed similar clinical response rates (31.7% vs 30.0%) and lower treatment failure rates (45.0% vs 55.0%; P=0.847), but higher pneumonia-related (10.0% vs 1.7%; OR, 6.425; P=0.059) and all-cause mortality (18.3% vs 3.3%; OR, 6.564; P=0.013) at hospital discharge for linezolid compared to vancomycin treated patients.11 Results from this study however, should be evaluated cautiously as differences existed between the linezolid and vancomycin matched treatment groups and enrolled patients were diagnosed with HAP, not exclusively gram-positive HAP.

Results from the two retrospective analyses in patients with MRSA VAP showed higher clinical success with no difference in mortality between linezolid and vancomycin treated patients similar to the results from the prospective studies.10,39

Meta-analyses

Although numerous meta-analyses evaluated the role of linezolid in the treatment of patients with pneumonia,40–49 only five directly compared linezolid and vancomycin therapy.40,41,44,47,49 In general, results from these analyses show similar40,41,47,49 or increased44 clinical success with linezolid compared to vancomycin therapy (Table 3). Only two analyses compared mortality rates between patients treated with vancomycin and linezolid therapy for nosocomial pneumonia; no difference in mortality rates was found.47,49

Table 3

Meta-analyses results for studies comparing linezolid and vancomycin therapy in patients with gram-positive pneumonia

Reference	Studies, n	Patients, n/Na		Outcome LIN vs VANb	P-value
		LIN	VAN
Wang et al49	9	551	519	Clinical cure: RR 1.08 (0.98–1.18)	0.11
	4	171	163	MRSA clinical cure: RR 1.16 (0.95–1.43)	0.15
	7	318	282	Micro success: RR 1.12 (0.96–1.30)	0.15
	6	130	107	MRSA eradication: RR 1.16 (0.93–1.45)	0.19
	4	1,196	1,156	Mortality: RR 0.88 (0.74–1.05)	0.16
	4	1,196	1,156	Nephrotoxicity: RR 0.50 (0.31–0.81)	0.005
	4	1,196	1,156	Thrombocytopenia: RR 0.77 (0.35–1.60)	0.51
	4	1,196	1,156	Gastrointestinal effects: RR 1.33 (0.76–2.34)	0.32
Jiang et al44	10	380/605	328/544	Tx success: RR 1.09 (95% CI: 0.99–1.19)	0.07
	8	234/391	196/375	Micro success: RR 1.16 (95% CI: 1.02–1.31)	0.02
	12c	NR	NR	Mortality: RR 0.95 (95% CI: 0.83–1.09)	0.46
	9c	NR	NR	Anemia: RR 1.14 (95% CI: 0.73–1.79)	0.55
	9c	NR	NR	Thrombocytopenia: RR 1.58 (95% CI: 0.75–3.33)	0.23
	9c	NR	NR	Renal: RR 0.41 (95% CI: 0.27–0.64)	<0.001
Bally et al40	3	240/563	217/527	Clin success: OR 1.06 (95% CI: 0.75–1.51)	NR
	2d	114/209	106/231	Clin success MRSA: OR 1.37 (95% CI: 0.72–2.44)	NR
	3	NR/1,021	NR/1,082	Mortality: OR 0.85 (95% CI: 0.58–1.22)	NR
	3	NR/874	NR/852	Serious AE: OR 0.93 (95% CI: 0.62–1.32)	NR
Beibei et al41	7	253/398	229/360	Clin success: OR 1.16 (95% CI: 0.85, 1.57)	NR
Lin et al47,e	7	NR	NR	Clin success: OR 1.11 (95% CI: 0.82–1.53)	>0.05
	7	NR	NR	Mortality: OR 0.80 (95% CI: 0.59–1.07)	>0.05
	7	NR	NR	AE: OR 1.06 (95% CI: 0.68–1.64)	>0.05

Notes:

n Equals number of successfully treated patients, N equals the total number of patients; data presented as number of successfully treated patients;

data presented as OR or RR (95% CI);

comparison between linezolid and glycopeptides;

patients with confirmed MRSA pneumonia;

article published in Chinese; data obtained from English abstract.

Abbreviations: AE, adverse event; Clin, clinical; CI, confidence interval; LIN, linezolid; Micro, microbiologic; NR, not reported; RR, risk ratio; Tx, treatment; VAN, vancomycin; MRSA, methicillin-resistant Staphylococcus aureus; OR, odds ratio.

Analysis of clinical evidence

Numerous studies evaluated the efficacy and safety of linezolid in the treatment of patients with suspected or proven gram-positive pneumonia.8,10,31,32,35–37 In general, results from these studies show higher or similar clinical success for linezolid versus vancomycin therapy with no difference in mortality.

Differences in outcomes reported for these studies can potentially be explained by differences in populations evaluated. Similar or higher clinical success for linezolid versus vancomycin therapy was reported in studies that enrolled patients with culture-proven MRSA HAP or at a minimum documented or presumed gram-positive HAP.

Lower clinical response rates were reported in the real-world study conducted in the People’s Republic of China.11 In this study, linezolid and vancomycin therapy were initiated for the empiric treatment of HAP; few patients underwent microbiologic testing. The lower clinical response rates reported for this study suggest that at least some linezolid and vancomycin treated patients had non-gram-positive HAP which is consistent with epidemiological data showing that the majority of HAP cases in the People’s Republic of China are due to gram-negative organisms.4,5 The authors of this study stated that the routine microbiological assessment of patients with HAP is not routinely performed in Chinese tertiary care hospitals. A clearer understanding of the antimicrobial treatment of patients with HAP in Chinese tertiary care hospitals is needed in order to promote the rational use of antimicrobials in this setting.

Economic evidence

ZEPHyR analysis

The economic impact of linezolid compared to vancomycin therapy for the treatment of gram-positive nosocomial pneumonia was evaluated in several clinical trials including the ZEPHyR trial. Economic results from the ZEPHyR trial for patients with MRSA nosocomial pneumonia show similar overall costs for linezolid ($45,004) and vancomycin ($44,897) treated patients despite linezolid’s higher drug acquisition price (Figure 1).50 The higher drug cost for linezolid was offset by lower non-significant cost differences in reduced bed days and dialysis utilization for linezolid compared to vancomycin therapy. Results from this cost-effectiveness analysis show that linezolid treatment provides better efficacy with lower or only slightly higher costs than vancomycin treatment for the majority (73%) of bootstrap samples evaluated; linezolid treatment dominated vancomycin treatment in 24% of bootstrap samples having both better efficacy and lower costs. In the ZEPHyR trial, total costs were higher for patients who developed renal failure compared to those who did not (Figure 2).50 This increase in costs for patients with renal failure was driven by significantly higher mechanical ventilation (12 vs 7.8 days) and intensive care unit (13.5 vs 10 days) days. Although the number of patients who developed renal failure in the ZEPHyR trial was low overall (n=43), fewer linezolid (n=9) than vancomycin (n=34) treated patients developed renal failure (P<0.001).

Figure 1

Mean cost by treatment for patients enrolled in the ZEPHyR trial (modified intent-to-treat population).

Note: Reprinted from Clinical Therapeutics, 36(9), Niederman MS, Chastre J, Solem CT, et al, Health economic evaluation of patients treated for nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus: secondary analysis of a multicenter randomized clinical trial of vancomycin and linezolid, 1233–1243. Copyright 2014, with permission from Elsevier.50

Abbreviation: MV, mechanical ventilation.

Figure 2

Mean cost by renal failure status for patients enrolled in the ZEPHyR trial (modified intent-to-treat population).

Note: Reprinted from Clinical Therapeutics, 36(9), Niederman MS, Chastre J, Solem CT, et al, Health economic evaluation of patients treated for nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus: secondary analysis of a multicenter randomized clinical trial of vancomycin and linezolid, 1233–1243. Copyright 2014, with permission from Elsevier.50

Abbreviation: MV, mechanical ventilation.

Post hoc ZEPHyR analysis: Chinese perspective

Data from four cities representing geographical areas in the North (Beijing), South (Guangzhou), East (Nanjing), and West (Xi’an) were utilized to capture economic and clinical differences in treating patients with nosocomial pneumonia in the People’s Republic of China.9 Total treatment costs were highest in Guangzhou and lowest in Xi’an; total treatment costs for linezolid and vancomycin therapy were similar when compared within each city (Figure 3). Results from this analysis show a tradeoff between costs and effectiveness for tier 3A hospitals located in Beijing, Guangzhou, Nanjing, and Xi’an.

Figure 3

Mean cost by treatment for linezolid and vancomycin therapy in Beijing, Guangzhou, Nanjing, and Xi’an, the People’s Republic of China.

Note: Courtesy of Wan et al.9

Total inpatient costs were similar between linezolid and vancomycin therapy in all four cities evaluated. Total inpatient costs for linezolid ranged from ¥58,835 to ¥86,894 and for vancomycin ¥58,390 to ¥87,033. Analysis by city shows that linezolid compared to vancomycin therapy was dominant in Guangzhou, meaning linezolid compared to vancomycin therapy had a higher probability of treatment success with lower total treatment costs. Linezolid therapy was associated with an incremental cost-effectiveness ratio of ¥1,861 in Beijing, ¥163 in Nanjing, and ¥16,509 in Xi’an. Results for sensitivity analyses suggested by Chinese clinical experts show that linezolid dominated vancomycin therapy for many of the scenarios evaluated in all four cities.

Retrospective analysis

Results from a retrospective analysis conducted in Shanghai, People’s Republic of China, were similar to those previously reported.11 Although drug costs were higher for linezolid compared to vancomycin therapy, median total hospital costs for linezolid (¥133,825) and vancomycin (¥113,160; P=0.076) therapy for patients with HAP did not significantly differ.

Conclusion

Hospitalized patients with MRSA nosocomial pneumonia have few treatment options. Historically, this patient population was treated with intravenous vancomycin therapy. Published evidence from both clinical studies and meta-analyses suggest similar if not better outcomes for patients with MRSA nosocomial pneumonia treated with linezolid compared to vancomycin therapy. Evidence from economic studies, including those conducted from a Chinese perspective, suggests that linezolid is a cost-effective therapy for hospitalized patients with MRSA nosocomial pneumonia. Both clinical and economic evidence supports the use of linezolid for the treatment of patients with MRSA nosocomial pneumonia.