| Literature DB >> 27067314 |
Qiu E Yang1, Timothy Rutland Walsh2, Bao Tao Liu1, Meng Ting Zou1, Hui Deng1, Liang Xing Fang1, Xiao Ping Liao1, Jian Sun3, Ya Hong Liu4.
Abstract
We sequenced a novel conjugative multidrug resistance IncF plasmid, p42-2, isolated from Escherichia coli strain 42-2, previously identified in China. p42-2 is 106,886 bp long, composed of a typical IncFII-type backbone (∼54 kb) and one distinct acquired DNA region spanning ∼53 kb, harboring 12 antibiotic resistance genes [blaCTX-M-55, oqxA, oqxB, fosA3, floR, tetA(A), tetA(R), strA, strB, sul2, aph(3')-II, and ΔblaTEM-1]. The spread of these multidrug resistance determinants on the same plasmid is of great concern and, because of coresistance to antibiotics from different classes, is therapeutically challenging.Entities:
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Year: 2016 PMID: 27067314 PMCID: PMC4914668 DOI: 10.1128/AAC.00475-16
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191