Literature DB >> 27062332

The complex nature of fragile site plasticity and its importance in cancer.

Dan Sarni1, Batsheva Kerem2.   

Abstract

Common fragile sites (CFSs) are chromosomal regions characterized as hotspots for breakage and chromosomal rearrangements following DNA replication stress. They are preferentially unstable in pre-cancerous lesions and during cancer development. Recently CFSs were found to be tissue- and even oncogene-induced specific, thus indicating an unforeseen complexity. Here we review recent developments in CFS research that shed new light on the molecular basis of their instability and their importance in cancer development.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27062332     DOI： 10.1016/j.ceb.2016.03.017

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  29 in total

Review 1.  Close encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts.

Authors:  Aris A Polyzos; Cynthia T McMurray
Journal:  DNA Repair (Amst)       Date:  2017-06-09

Review 2.  Fragility Extraordinaire: Unsolved Mysteries of Chromosome Fragile Sites.

Authors:  Wenyi Feng; Arijita Chakraborty
Journal:  Adv Exp Med Biol       Date:  2017       Impact factor: 2.622

Review 3.  Modulation of the DNA damage response during the life cycle of human papillomaviruses.

Authors:  Daniel C Anacker; Cary A Moody
Journal:  Virus Res       Date:  2016-11-09       Impact factor: 3.303

Review 4.  Fragile sites in cancer: more than meets the eye.

Authors:  Thomas W Glover; Thomas E Wilson; Martin F Arlt
Journal:  Nat Rev Cancer       Date:  2017-07-25       Impact factor: 60.716

5.  Remarkably Long-Tract Gene Conversion Induced by Fragile Site Instability in Saccharomyces cerevisiae.

Authors:  Shahana A Chumki; Mikael K Dunn; Thomas F Coates; Jeanmarie D Mishler; Ellen M Younkin; Anne M Casper
Journal:  Genetics       Date:  2016-06-24       Impact factor: 4.562

6.  FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells.

Authors:  Constanze Pentzold; Shiraz Ali Shah; Niels Richard Hansen; Benoît Le Tallec; Andaine Seguin-Orlando; Michelle Debatisse; Michael Lisby; Vibe H Oestergaard
Journal:  Nucleic Acids Res       Date:  2018-02-16       Impact factor: 16.971

7.  Loss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish.

Authors:  Hyewon Park; Richard Galbraith; Thaddeus Turner; Justin Mehojah; Mizuki Azuma
Journal:  Sci Rep       Date:  2016-08-25       Impact factor: 4.379

Review 8.  Mechanisms by which HPV Induces a Replication Competent Environment in Differentiating Keratinocytes.

Authors:  Cary Moody
Journal:  Viruses       Date:  2017-09-19       Impact factor: 5.048

9.  Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.

Authors:  Lijuan Zhang; Kai Zhang; Jieyou Zhang; Jinrong Zhu; Qing Xi; Huafeng Wang; Zimu Zhang; Yingnan Cheng; Guangze Yang; Hongkun Liu; Xiangdong Guo; Dongmei Zhou; Zhenyi Xue; Yan Li; Qi Zhang; Yurong Da; Li Liu; Zhinan Yin; Zhi Yao; Rongxin Zhang
Journal:  Nat Commun       Date:  2021-07-14       Impact factor: 14.919

10.  Replication stress induces accumulation of FANCD2 at central region of large fragile genes.

Authors:  Yusuke Okamoto; Watal M Iwasaki; Kazuto Kugou; Kazuki K Takahashi; Arisa Oda; Koichi Sato; Wataru Kobayashi; Hidehiko Kawai; Ryo Sakasai; Akifumi Takaori-Kondo; Takashi Yamamoto; Masato T Kanemaki; Masato Taoka; Toshiaki Isobe; Hitoshi Kurumizaka; Hideki Innan; Kunihiro Ohta; Masamichi Ishiai; Minoru Takata
Journal:  Nucleic Acids Res       Date:  2018-04-06       Impact factor: 16.971
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