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Literature DB >> 27059426

DNA Walker-Regulated Cancer Cell Growth Inhibition.

Feiran Li¹, Tae-Gon Cha¹, Jing Pan¹, Altug Ozcelikkale¹, Bumsoo Han¹, Jong Hyun Choi².

Abstract

We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. In this system, AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anticancer oligonucleotides are controlled by the walker operation. With a walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in situ cancer cell growth inhibition.

Entities: CellLine Chemical Disease Gene Species

Keywords: DNA walker; DNAzyme; anticancer; growth inhibition; oligonucleotides

Mesh：

Substances：

Year: 2016 PMID： 27059426 PMCID： PMC5051347 DOI： 10.1002/cbic.201600052

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

34 in total

Review 1. DNA nanomachines.

Authors: Jonathan Bath; Andrew J Turberfield
Journal: Nat Nanotechnol Date: 2007-05 Impact factor: 39.213

DNA Walker-Regulated Cancer Cell Growth Inhibition.

Review 1. DNA nanomachines.

2. Promises, facts and challenges for carbon nanotubes in imaging and therapeutics.

Review 3. Recent progress on DNA based walkers.

4. Design Principles of DNA Enzyme-Based Walkers: Translocation Kinetics and Photoregulation.

5. Understanding the toxicity of carbon nanotubes.

6. Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA.

7. Inhibition of DNA replication and induction of S phase cell cycle arrest by G-rich oligonucleotides.

8. The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells.

9. Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker.

10. Nucleolin targeting AS1411 modified protein nanoparticle for antitumor drugs delivery.

Review 1. Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications.

2. Visible/near-infrared subdiffraction imaging reveals the stochastic nature of DNA walkers.

Review 3. Dynamic DNA Assemblies in Biomedical Applications.

4. Static DNA Nanostructures For Cancer Theranostics: Recent Progress In Design And Applications.

5. Assembly of Dynamic Gated and Cascaded Transient DNAzyme Networks.

6. Regeneration of Burnt Bridges on a DNA Catenane Walker.