Literature DB >> 27057461

Interferon gamma/NADPH oxidase defense system in immunity and cancer.

Zdenek Hodny1, Milan Reinis2, Sona Hubackova1, Pavla Vasicova3, Jiri Bartek4.   

Abstract

As a part of cellular pathogen defense, IFNγ triggers induction of NADPH oxidase NOX2, which produces superoxide into phagosomes of immune cells. Recent data show that a similar mechanism can also operate in IFNγ-mediated anticancer control. IFNγ is capable of inducing expression of constitutively active NADPH oxidase NOX4 in tumor cells leading to generation of reactive oxygen species (ROS) damaging DNA, activation of DNA damage response and cell cycle arrest/premature cellular senescence.

Entities:  

Keywords:  Cellular senescence; DNA damage response; oxidative stress; tumor growth factor beta; tumor immunosurveillance

Year:  2015        PMID： 27057461      PMCID： PMC4801460          DOI： 10.1080/2162402X.2015.1080416

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation.

Authors:  Rabii Ameziane-El-Hassani; Monique Talbot; Maria Carolina de Souza Dos Santos; Abir Al Ghuzlan; Dana Hartl; Jean-Michel Bidart; Xavier De Deken; Françoise Miot; Ibrahima Diallo; Florent de Vathaire; Martin Schlumberger; Corinne Dupuy
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-06       Impact factor: 11.205

Review 2.  Interferons, immunity and cancer immunoediting.

Authors:  Gavin P Dunn; Catherine M Koebel; Robert D Schreiber
Journal:  Nat Rev Immunol       Date:  2006-11       Impact factor: 53.106

3.  Inactivation of NADPH oxidases NOX4 and NOX5 protects human primary fibroblasts from ionizing radiation-induced DNA damage.

Authors:  Urbain Weyemi; Christophe E Redon; Towqir Aziz; Rohini Choudhuri; Daisuke Maeda; Palak R Parekh; Michael Y Bonner; Jack L Arbiser; William M Bonner
Journal:  Radiat Res       Date:  2015-02-23       Impact factor: 2.841

4.  IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.

Authors:  S Hubackova; A Kucerova; G Michlits; L Kyjacova; M Reinis; O Korolov; J Bartek; Z Hodny
Journal:  Oncogene       Date:  2015-05-18       Impact factor: 9.867

5.  T-helper-1-cell cytokines drive cancer into senescence.

Authors:  Heidi Braumüller; Thomas Wieder; Ellen Brenner; Sonja Aßmann; Matthias Hahn; Mohammed Alkhaled; Karin Schilbach; Frank Essmann; Manfred Kneilling; Christoph Griessinger; Felicia Ranta; Susanne Ullrich; Ralph Mocikat; Kilian Braungart; Tarun Mehra; Birgit Fehrenbacher; Julia Berdel; Heike Niessner; Friedegund Meier; Maries van den Broek; Hans-Ulrich Häring; Rupert Handgretinger; Leticia Quintanilla-Martinez; Falko Fend; Marina Pesic; Jürgen Bauer; Lars Zender; Martin Schaller; Klaus Schulze-Osthoff; Martin Röcken
Journal:  Nature       Date:  2013-02-03       Impact factor: 49.962

6.  ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence.

Authors:  Ryo Kodama; Masayoshi Kato; Shuichi Furuta; Shouta Ueno; Yugen Zhang; Kuniharu Matsuno; Chihiro Yabe-Nishimura; Eiji Tanaka; Tohru Kamata
Journal:  Genes Cells       Date:  2012-12-06       Impact factor: 1.891

7.  Decitabine induces delayed reactive oxygen species (ROS) accumulation in leukemia cells and induces the expression of ROS generating enzymes.

Authors:  Tamer E Fandy; Anchalee Jiemjit; Manjusha Thakar; Paulette Rhoden; Lauren Suarez; Steven D Gore
Journal:  Clin Cancer Res       Date:  2014-01-14       Impact factor: 12.531

Review 8.  Regulation of Nox and Duox enzymatic activity and expression.

Authors:  J David Lambeth; Tsukasa Kawahara; Becky Diebold
Journal:  Free Radic Biol Med       Date:  2007-04-01       Impact factor: 7.376

9.  ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence.

Authors:  U Weyemi; O Lagente-Chevallier; M Boufraqech; F Prenois; F Courtin; B Caillou; M Talbot; M Dardalhon; A Al Ghuzlan; J-M Bidart; M Schlumberger; C Dupuy
Journal:  Oncogene       Date:  2011-08-15       Impact factor: 9.867

10.  IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'.

Authors:  Sona Hubackova; Katerina Krejcikova; Jiri Bartek; Zdenek Hodny
Journal:  Aging (Albany NY)       Date:  2012-12       Impact factor: 5.682
  10 in total
  10 in total

Review 1.  Trial watch: Immune checkpoint blockers for cancer therapy.

Authors:  Claire Vanpouille-Box; Claire Lhuillier; Lucillia Bezu; Fernando Aranda; Takahiro Yamazaki; Oliver Kepp; Jitka Fucikova; Radek Spisek; Sandra Demaria; Silvia C Formenti; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2017-08-31       Impact factor: 8.110

Review 2.  The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis Pathogenesis.

Authors:  Caterina Veroni; Francesca Aloisi
Journal:  Front Immunol       Date:  2021-07-07       Impact factor: 7.561

3.  The DNA damage induced by the Cytosine Deaminase APOBEC3A Leads to the production of ROS.

Authors:  Mathilde Niocel; Romain Appourchaux; Xuan-Nhi Nguyen; Mathilde Delpeuch; Andrea Cimarelli
Journal:  Sci Rep       Date:  2019-03-18       Impact factor: 4.379

4.  Protective Effect of Selenium-L-methionine on Radiation-induced Acute Pneumonitis and Lung Fibrosis in Rat.

Authors:  Peyman Amini; Sedighe Kolivand; Hana Saffar; Saeed Rezapoor; Elahe Motevaseli; Masoud Najafi; Farzad Nouruzi; Dheyauldeen Shabeeb; Ahmed Eleojo Musa
Journal:  Curr Clin Pharmacol       Date:  2019

5.  Impairment of Multiple Mitochondrial Energy Metabolism Pathways in the Heart of Chagas Disease Cardiomyopathy Patients.

Authors:  Priscila Camillo Teixeira; Axel Ducret; Hanno Langen; Everson Nogoceke; Ronaldo Honorato Barros Santos; João Paulo Silva Nunes; Luiz Benvenuti; Debora Levy; Sergio Paulo Bydlowski; Edimar Alcides Bocchi; Andréia Kuramoto Takara; Alfredo Inácio Fiorelli; Noedir Antonio Stolf; Pablo Pomeranzeff; Christophe Chevillard; Jorge Kalil; Edecio Cunha-Neto
Journal:  Front Immunol       Date:  2021-11-12       Impact factor: 7.561

Review 6.  Intratumoral pro-oxidants promote cancer immunotherapy by recruiting and reprogramming neutrophils to eliminate tumors.

Authors:  Stephen John Ralph; Maxwell J Reynolds
Journal:  Cancer Immunol Immunother       Date:  2022-08-17       Impact factor: 6.630

7.  Interferon γ neutralization reduces blood pressure, uterine artery resistance index, and placental oxidative stress in placental ischemic rats.

Authors:  Olivia K Travis; Geilda A Tardo; Chelsea Giachelli; Shani Siddiq; Henry T Nguyen; Madison T Crosby; Tyler D Johnson; Andrea K Brown; George W Booz; Alex N Smith; Jan Michael Williams; Denise C Cornelius
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2021-06-02       Impact factor: 3.210

8.  Metabolic characterization and pathway analysis of berberine protects against prostate cancer.

Authors:  Xianna Li; Aihua Zhang; Hui Sun; Zhidong Liu; Tianlei Zhang; Shi Qiu; Liang Liu; Xijun Wang
Journal:  Oncotarget       Date:  2017-04-28

9.  Connecting Immune Cell Infiltration to the Multitasking Microglia Response and TNF Receptor 2 Induction in the Multiple Sclerosis Brain.

Authors:  Caterina Veroni; Barbara Serafini; Barbara Rosicarelli; Corrado Fagnani; Francesca Aloisi; Cristina Agresti
Journal:  Front Cell Neurosci       Date:  2020-07-07       Impact factor: 5.505

10.  Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state.

Authors:  Rashed Alhammad; Sasiprapa Khunchai; Nopprarat Tongmuang; Thawornchai Limjindaporn; Pa-Thai Yenchitsomanus; Luciano Mutti; Marija Krstic-Demonacos; Constantinos Demonacos
Journal:  Oncol Rep       Date:  2020-10-20       Impact factor: 3.906
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.