Annalisa Barera1, Silvio Buscemi2, Roberto Monastero3, Calogero Caruso1, Rosalia Caldarella4, Marcello Ciaccio5, Sonya Vasto6. 1. Pathobiology Department and Biomedical Technologies (DIBIMED), University of Palermo, Palermo, Italy. 2. Biomedic Department of Internal and Specialistic Medicine (DIBIMIS), University of Palermo, Palermo, Italy. 3. Department of Experimental Biomedicine and Clinical Neuroscience (BioNeC), University of Palermo, Palermo, Italy. 4. CORELAB, Policlinico Paolo Giaccone, University of Palermo, Palermo, Italy. 5. Pathobiology Department and Biomedical Technologies (DIBIMED), University of Palermo, Palermo, Italy ; Biomedic Department of Internal and Specialistic Medicine (DIBIMIS), University of Palermo, Palermo, Italy ; Department of Experimental Biomedicine and Clinical Neuroscience (BioNeC), University of Palermo, Palermo, Italy ; CORELAB, Policlinico Paolo Giaccone, University of Palermo, Palermo, Italy. 6. Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, Building 16, Palermo, Italy ; Institute of biomedicine and molecular immunology "Alberto Monroy" CNR, Palermo, Italy.
Abstract
BACKGROUND: It is well known that Mediterranean Diet can positively influence the health of each individual, in particular it is know that fibers have an important role. However, in Mediterranean cities most people do not have a close adherence to Mediterranean diet. Thus, in our study, we considered fibers like β-glucans that have been added to pasta with a percentage of 6 %. Our study aimed to evaluate the capacity of β-glucans intake on oxidative stress and inflammation in a cohort of middle aged slightly overweight subjects. METHODS: We used a longitudinal study design. The study lasted 30 days during which time, each participant acted with no food restriction. Participants underwent morning fasting blood venous sample for blood chemistry and other biological parameters at the beginning of the study and after 30 days of pasta supplemented with 6 % of β-glucan intake 4 times a week. We performed anthropometric, biochemical, oxidative stress and cytokine analysis at the beginning and the end of study. RESULTS: After the 30 days of pasta intake we obtained a significant decrease of LDL-cholesterol, IL-6 and AGEs levels. CONCLUSION: The results confirmed a capacity of β-glucans intake to lower oxidative stress. Additional longitudinal observation on community-based cohorts are needed to confirm these data and investigate the biological mechanisms through which effects are induced, and to fully explore the therapeutic potential of β-glucans.
BACKGROUND: It is well known that Mediterranean Diet can positively influence the health of each individual, in particular it is know that fibers have an important role. However, in Mediterranean cities most people do not have a close adherence to Mediterranean diet. Thus, in our study, we considered fibers like β-glucans that have been added to pasta with a percentage of 6 %. Our study aimed to evaluate the capacity of β-glucans intake on oxidative stress and inflammation in a cohort of middle aged slightly overweight subjects. METHODS: We used a longitudinal study design. The study lasted 30 days during which time, each participant acted with no food restriction. Participants underwent morning fasting blood venous sample for blood chemistry and other biological parameters at the beginning of the study and after 30 days of pasta supplemented with 6 % of β-glucan intake 4 times a week. We performed anthropometric, biochemical, oxidative stress and cytokine analysis at the beginning and the end of study. RESULTS: After the 30 days of pasta intake we obtained a significant decrease of LDL-cholesterol, IL-6 and AGEs levels. CONCLUSION: The results confirmed a capacity of β-glucans intake to lower oxidative stress. Additional longitudinal observation on community-based cohorts are needed to confirm these data and investigate the biological mechanisms through which effects are induced, and to fully explore the therapeutic potential of β-glucans.
Authors: Peter Toth; Stefano Tarantini; Zsolt Springo; Zsuzsanna Tucsek; Tripti Gautam; Cory B Giles; Jonathan D Wren; Akos Koller; William E Sonntag; Anna Csiszar; Zoltan Ungvari Journal: Aging Cell Date: 2015-02-09 Impact factor: 9.304