Priscila M S Castanha1, Cynthia Braga2, Marli T Cordeiro1, Ariani I Souza3, Claudeir D Silva3, Celina M T Martelli4, Willem G van Panhuis5, Eduardo J M Nascimento6, Ernesto T A Marques7. 1. Aggeu Magalhães Research Center, Oswaldo Cruz Foundation. 2. Aggeu Magalhães Research Center, Oswaldo Cruz Foundation Instituto de Medicina Integral Prof Fernando Figueira, Recife. 3. Instituto de Medicina Integral Prof Fernando Figueira, Recife. 4. Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, Brazil. 5. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health. 6. Center for Vaccine Research Department of Infectious Disease and Microbiology, University of Pittsburgh, Pennsylvania. 7. Aggeu Magalhães Research Center, Oswaldo Cruz Foundation Center for Vaccine Research Department of Infectious Disease and Microbiology, University of Pittsburgh, Pennsylvania.
Abstract
BACKGROUND: Maternal-fetal transferred dengue virus (DENV)-specific antibodies have been implicated in the immunopathogenesis of dengue during infancy. METHODS: A prospective birth cohort was established in a dengue-endemic area in the Northeast Region of Brazil. DENV-specific immunoglobulin G (IgG) and DENV-1-4 serotype-specific neutralizing antibody (NAb) levels were assessed in 376 paired maternal and umbilical cord blood samples. The kinetics of enhancing activity by maternally acquired DENV antibodies was determined in serum samples from children enrolled in the cohort. RESULTS: Mothers were mostly immune to DENV-3 alone (53.7%) or combined with DENV-4 (30.6%). Levels of DENV-specific IgG, DENV-3 NAbs, and DENV-4 NAbs were significantly higher in newborns than in their respective mothers. Mothers immune to a single serotype transferred greater levels of DENV-specific IgG (P = .02) and DENV-3 NAbs (P = .04) than mothers immune to multiple DENV serotypes. Maternally acquired DENV-3 NAbs disappeared in >90% of the children by the age of 4 months. The peak enhancing activity was detected by the age of 2 months (P < .0001) and rapidly declined by the age of 4 months (P = .0035). CONCLUSIONS: Unlike Asian infants, the enhancing activity of DENV infection by maternally transferred DENV antibodies occurs at earlier ages in Brazilian children. These findings might explain the low occurrence of severe dengue among infants in our setting.
BACKGROUND: Maternal-fetal transferred dengue virus (DENV)-specific antibodies have been implicated in the immunopathogenesis of dengue during infancy. METHODS: A prospective birth cohort was established in a dengue-endemic area in the Northeast Region of Brazil. DENV-specific immunoglobulin G (IgG) and DENV-1-4 serotype-specific neutralizing antibody (NAb) levels were assessed in 376 paired maternal and umbilical cord blood samples. The kinetics of enhancing activity by maternally acquired DENV antibodies was determined in serum samples from children enrolled in the cohort. RESULTS: Mothers were mostly immune to DENV-3 alone (53.7%) or combined with DENV-4 (30.6%). Levels of DENV-specific IgG, DENV-3 NAbs, and DENV-4 NAbs were significantly higher in newborns than in their respective mothers. Mothers immune to a single serotype transferred greater levels of DENV-specific IgG (P = .02) and DENV-3 NAbs (P = .04) than mothers immune to multiple DENV serotypes. Maternally acquired DENV-3 NAbs disappeared in >90% of the children by the age of 4 months. The peak enhancing activity was detected by the age of 2 months (P < .0001) and rapidly declined by the age of 4 months (P = .0035). CONCLUSIONS: Unlike Asian infants, the enhancing activity of DENV infection by maternally transferred DENV antibodies occurs at earlier ages in Brazilian children. These findings might explain the low occurrence of severe dengue among infants in our setting.
Authors: M I de Moraes-Pinto; A C Almeida; G Kenj; T E Filgueiras; W Tobias; A M Santos; M M Carneiro-Sampaio; C K Farhat; P J Milligan; P M Johnson; C A Hart Journal: J Infect Dis Date: 1996-05 Impact factor: 5.226
Authors: Susana Scott; William J Moss; Simon Cousens; Judy A Beeler; Susette A Audet; Nanthalile Mugala; Thomas C Quinn; Diane E Griffin; Felicity T Cutts Journal: Clin Infect Dis Date: 2007-10-22 Impact factor: 9.079
Authors: Rachel C Leite; Ariani I Souza; Priscila M S Castanha; Marli T Cordeiro; Celina T Martelli; Ana Laura G Ferreira; Leila Katz; Cynthia Braga Journal: J Clin Virol Date: 2014-03-02 Impact factor: 3.168
Authors: Marli Tenório Cordeiro; Ana Maria Silva; Carlos A A Brito; Eduardo J M Nascimento; Maria Cecilia F Magalhães; Georgia F Guimarães; Norma Lucena-Silva; Eduardo M Freese de Carvalho; Ernesto T A Marques Journal: Am J Trop Med Hyg Date: 2007-12 Impact factor: 2.345
Authors: Nigel M Stapleton; Jan Terje Andersen; Annette M Stemerding; Stefania P Bjarnarson; Ruurd C Verheul; Jacoline Gerritsen; Yixian Zhao; Marion Kleijer; Inger Sandlie; Masja de Haas; Ingileif Jonsdottir; C Ellen van der Schoot; Gestur Vidarsson Journal: Nat Commun Date: 2011-12-20 Impact factor: 14.919
Authors: Matthew G Zimmerman; Kendra M Quicke; Justin T O'Neal; Nitin Arora; Deepa Machiah; Lalita Priyamvada; Robert C Kauffman; Emery Register; Oluwaseyi Adekunle; Dominika Swieboda; Erica L Johnson; Sarah Cordes; Lisa Haddad; Rana Chakraborty; Carolyn B Coyne; Jens Wrammert; Mehul S Suthar Journal: Cell Host Microbe Date: 2018-11-14 Impact factor: 21.023
Authors: Isabel Rodriguez-Barraquer; Federico Costa; Eduardo J M Nascimento; Nivison Nery; Priscila M S Castanha; Gielson Almeida Sacramento; Jaqueline Cruz; Mayara Carvalho; Daiana De Olivera; José E Hagan; Haritha Adhikarla; Elsio A Wunder; Danilo F Coêlho; Sasha R Azar; Shannan L Rossi; Nikos Vasilakis; Scott C Weaver; Guilherme S Ribeiro; Angel Balmaseda; Eva Harris; Maurício L Nogueira; Mitermayer G Reis; Ernesto T A Marques; Derek A T Cummings; Albert I Ko Journal: Science Date: 2019-02-08 Impact factor: 47.728
Authors: Priscila M S Castanha; Geza Erdos; Simon C Watkins; Louis D Falo; Ernesto T A Marques; Simon M Barratt-Boyes Journal: JCI Insight Date: 2020-02-13
Authors: Priscila M S Castanha; Eduardo J M Nascimento; Cynthia Braga; Marli T Cordeiro; Otávio V de Carvalho; Leila R de Mendonça; Elisa A N Azevedo; Rafael F O França; Rafael Dhalia; Ernesto T A Marques Journal: J Infect Dis Date: 2017-03-01 Impact factor: 5.226
Authors: Henry Puerta-Guardo; Scott B Biering; Francielle Tramontini Gomes de Sousa; Jeffrey Shu; Dustin R Glasner; Jeffrey Li; Sophie F Blanc; P Robert Beatty; Eva Harris Journal: Pathogens Date: 2022-05-24
Authors: P M S Castanha; U R Montarroyos; S M M Silveira; G D M Albuquerque; M J G Mello; K G S Lopes; M T Cordeiro; E T A Marques; C M T Martelli; C Braga Journal: Epidemiol Infect Date: 2017-09-18 Impact factor: 4.434
Authors: Arad Kodesh; Stephen Z Levine; Vahe Khachadourian; Rayees Rahman; Avner Schlessinger; Paul F O'Reilly; Jakob Grove; Diana Schendel; Joseph D Buxbaum; Lisa Croen; Abraham Reichenberg; Sven Sandin; Magdalena Janecka Journal: Psychol Med Date: 2021-03-26 Impact factor: 10.592
Authors: Enny S Paixão; Maria Glória Teixeira; Maria da Conceição N Costa; Mauricio L Barreto; Laura C Rodrigues Journal: Emerg Infect Dis Date: 2018-09 Impact factor: 6.883