| Literature DB >> 30733412 |
Isabel Rodriguez-Barraquer1, Federico Costa2,3,4, Eduardo J M Nascimento5, Nivison Nery2,3, Priscila M S Castanha6,7, Gielson Almeida Sacramento3, Jaqueline Cruz3, Mayara Carvalho3, Daiana De Olivera3, José E Hagan3,4, Haritha Adhikarla4, Elsio A Wunder3,4, Danilo F Coêlho6,8, Sasha R Azar9, Shannan L Rossi10, Nikos Vasilakis11, Scott C Weaver10, Guilherme S Ribeiro2,3,12, Angel Balmaseda13,14, Eva Harris15, Maurício L Nogueira16, Mitermayer G Reis3,4,12, Ernesto T A Marques5,6,17, Derek A T Cummings18,19, Albert I Ko20,4.
Abstract
The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.Entities:
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Year: 2019 PMID： 30733412 PMCID： PMC8221194 DOI： 10.1126/science.aav6618
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728