| Literature DB >> 19911991 |
Tran Nguyen Bich Chau1, Nguyen Trong Hieu, Katherine L Anders, Marcel Wolbers, Le Bich Lien, Lu Thi Minh Hieu, Tran Tinh Hien, Nguyen Thanh Hung, Jeremy Farrar, Stephen Whitehead, Cameron P Simmons.
Abstract
Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of maternally derived DENV immunoglobulin (Ig) G and the incidence of DENV infection were determined in a prospectively studied cohort of 1244 Vietnamese infants. Higher concentrations of total IgG and DENV-reactive IgG were found in cord plasma relative to maternal plasma. Maternally derived DENV-neutralizing and E protein-reactive IgG titers declined to below measurable levels in >90% of infants by 6 months of age. In contrast, IgG reactive with whole DENV virions persisted until 12 months of age in 20% of infants. Serological surveillance identified 10 infants with asymptomatic DENV infection for an incidence of 1.7 cases per 100 person-years. DENV-neutralizing antibodies remained measurable for > or = 1 year after infection. These results suggest that whereas DENV infection in infants is frequently subclinical, there is a window between 4 and 12 months of age where virion-binding but nonneutralizing IgG could facilitate antibody-dependent enhancement.Entities:
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Year: 2009 PMID： 19911991 PMCID： PMC4340501 DOI： 10.1086/648407
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226