Literature DB >> 27041930

Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology.

Tianying Xing1, Huiying He1.   

Abstract

Clear cell renal cell carcinoma (ccRCC) is one frequent form of urologic malignancy with numerous genetic and epigenetic alterations. This review summarizes the recent major findings of epigenetic alterations including DNA methylation, histone modifications, microRNAs and recently identified long noncoding RNAs in the development and progression of ccRCC. These epigenetic profilings can provide a promising means of prognostication and early diagnosis for patients with ccRCCs. With the developed high-throughput technologies nowadays, the epigenetic analyses will have possible clinical applications in the molecular pathology of ccRCC.

Entities:  

Keywords:  DNA methylation; clear cell renal cell carcinoma (ccRCC); histone modification; long noncoding RNA; microRNA

Year:  2016        PMID： 27041930      PMCID： PMC4779762          DOI： 10.3978/j.issn.1000-9604.2016.02.09

Source DB:  PubMed          Journal:  Chin J Cancer Res        ISSN： 1000-9604            Impact factor:   5.087


  93 in total

1.  MicroRNA 15a, inversely correlated to PKCα, is a potential marker to differentiate between benign and malignant renal tumors in biopsy and urine samples.

Authors:  Melanie von Brandenstein; Jency J Pandarakalam; Lukas Kroon; Heike Loeser; Jan Herden; Gabriele Braun; Katherina Wendland; Hans P Dienes; Udo Engelmann; Ullrich Engelmann; Jochen W U Fries
Journal:  Am J Pathol       Date:  2012-03-17       Impact factor: 4.307

Review 2.  MicroRNAs involved in regulating epithelial-mesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics.

Authors:  H Xia; K M Hui
Journal:  Cancer Gene Ther       Date:  2012-09-14       Impact factor: 5.987

3.  The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C.

Authors:  X Niu; T Zhang; L Liao; L Zhou; D J Lindner; M Zhou; B Rini; Q Yan; H Yang
Journal:  Oncogene       Date:  2011-07-04       Impact factor: 9.867

4.  TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers.

Authors:  Vera L Costa; Rui Henrique; Stine Aske Danielsen; Mette Eknaes; Patrícia Patrício; António Morais; Jorge Oliveira; Ragnhild A Lothe; Manuel R Teixeira; Guro E Lind; Carmen Jerónimo
Journal:  Epigenetics       Date:  2011-09-01       Impact factor: 4.528

5.  Low expression of miR-126 is a prognostic marker for metastatic clear cell renal cell carcinoma.

Authors:  Heba W Z Khella; Andreas Scorilas; Roy Mozes; Lorna Mirham; Evi Lianidou; Sergey N Krylov; Jason Y Lee; Michael Ordon; Robert Stewart; Michael A S Jewett; George M Yousef
Journal:  Am J Pathol       Date:  2015-01-05       Impact factor: 4.307

6.  MicroRNA-218 inhibits cell migration and invasion in renal cell carcinoma through targeting caveolin-2 involved in focal adhesion pathway.

Authors:  Takeshi Yamasaki; Naohiko Seki; Hirofumi Yoshino; Toshihiko Itesako; Hideo Hidaka; Yasutoshi Yamada; Shuichi Tatarano; Tomokazu Yonezawa; Takashi Kinoshita; Masayuki Nakagawa; Hideki Enokida
Journal:  J Urol       Date:  2013-02-27       Impact factor: 7.450

Review 7.  Targeted therapy in metastatic renal carcinoma.

Authors:  Jane Mattei; Rodrigo Donalisio da Silva; David Sehrt; Wilson R Molina; Fernando J Kim
Journal:  Cancer Lett       Date:  2013-11-13       Impact factor: 8.679

8.  Epithelial-mesenchymal transition-related microRNA-200s regulate molecular targets and pathways in renal cell carcinoma.

Authors:  Hirofumi Yoshino; Hideki Enokida; Toshihiko Itesako; Shuichi Tatarano; Takashi Kinoshita; Miki Fuse; Satoko Kojima; Masayuki Nakagawa; Naohiko Seki
Journal:  J Hum Genet       Date:  2013-05-02       Impact factor: 3.172

Review 9.  DNA methylation profiling in the clinic: applications and challenges.

Authors:  Holger Heyn; Manel Esteller
Journal:  Nat Rev Genet       Date:  2012-09-04       Impact factor: 53.242

10.  Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma.

Authors:  Christopher J Ricketts; Mark R Morris; Dean Gentle; Michael Brown; Naomi Wake; Emma R Woodward; Noel Clarke; Farida Latif; Eamonn R Maher
Journal:  Epigenetics       Date:  2012-03       Impact factor: 4.528
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  28 in total

1.  Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study.

Authors:  Sercan Ergun; Sezgin Gunes; Recep Buyukalpelli; Oguz Aydin
Journal:  Int J Exp Pathol       Date:  2020-06-04       Impact factor: 1.925

2.  Differential sensitivity of renal carcinoma cells to doxorubicin and epigenetic therapeutics depends on the genetic background.

Authors:  Narayan Acharya; Kamaleshwar P Singh
Journal:  Mol Cell Biochem       Date:  2021-02-16       Impact factor: 3.396

Review 3.  The Role of Epigenetics in the Progression of Clear Cell Renal Cell Carcinoma and the Basis for Future Epigenetic Treatments.

Authors:  Javier C Angulo; Claudia Manini; Jose I López; Angel Pueyo; Begoña Colás; Santiago Ropero
Journal:  Cancers (Basel)       Date:  2021-04-25       Impact factor: 6.639

4.  Downregulation of METTL7B Inhibits Proliferation of Human Clear Cell Renal Cancer Cells In Vivo and In Vitro.

Authors:  Wei Li; Shi Xu; Naixiong Peng; Zejian Zhang; Hua He; Ruoyu Chen; Dong Chen; Jiqing Fan; Xisheng Wang
Journal:  Front Oncol       Date:  2021-02-26       Impact factor: 6.244

5.  High Expression of Stearoyl-CoA Desaturase 1 Predicts Poor Prognosis in Patients with Clear-Cell Renal Cell Carcinoma.

Authors:  Jianfeng Wang; Yunze Xu; Liangsong Zhu; Yun Zou; Wen Kong; Baijun Dong; Jiwei Huang; Yonghui Chen; Wei Xue; Yiran Huang; Jin Zhang
Journal:  PLoS One       Date:  2016-11-18       Impact factor: 3.240

6.  Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma.

Authors:  Ryuk-Jun Kwon; Yun Hak Kim; Dae Cheon Jeong; Myoung-Eun Han; Ji-Young Kim; Liangwen Liu; Jin-Sup Jung; Sae-Ock Oh
Journal:  PLoS One       Date:  2017-02-02       Impact factor: 3.240

7.  Aberrant Promoter Methylation of PCDH17 (Protocadherin 17) in Serum and its Clinical Significance in Renal Cell Carcinoma.

Authors:  Ying-Li Lin; Yun-Peng Wang; Hong-Zhao Li; Xu Zhang
Journal:  Med Sci Monit       Date:  2017-07-08

8.  Low hypoxia inducible factor-1α (HIF-1α) expression in testicular germ cell tumors - a major reason for enhanced chemosensitivity?

Authors:  Niraj Shenoy; Roxana Dronca; Fernando Quevedo; Stephen A Boorjian; John Cheville; Brian Costello; Manish Kohli; Thomas Witzig; Lance Pagliaro
Journal:  Chin J Cancer Res       Date:  2017-08       Impact factor: 5.087

9.  HiHiMap: single-cell quantitation of histones and histone posttranslational modifications across the cell cycle by high-throughput imaging.

Authors:  Linda Zane; Fleur Chapus; Gianluca Pegoraro; Tom Misteli
Journal:  Mol Biol Cell       Date:  2017-06-14       Impact factor: 4.138

Review 10.  Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma.

Authors:  Ali Mehdi; Yasser Riazalhosseini
Journal:  Int J Mol Sci       Date:  2017-08-16       Impact factor: 5.923
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