Joshua E Rosen1, Hari B Keshava2, Xiaopan Yao3, Anthony W Kim1, Frank C Detterbeck1, Daniel J Boffa4. 1. Section of Thoracic Surgery, Yale School of Medicine, New Haven, Connecticut. 2. Department of General Surgery, Cleveland Clinic Foundation, Cleveland, Ohio. 3. Yale Center for Analytical Sciences, Yale School of Public Health, New Haven, Connecticut. 4. Section of Thoracic Surgery, Yale School of Medicine, New Haven, Connecticut. Electronic address: daniel.boffa@yale.edu.
Abstract
BACKGROUND: The survival of untreated non-small cell lung cancer (NSCLC), or the natural history, is an important perspective for patients considering resection for NSCLC. The National Cancer Database (NCDB) allows untreated NSCLC patients who were recommended to undergo surgical resection (ie, "operable") to be identified. The survival of untreated NSCLC patients in the NCDB was studied to determine the natural history of operable NSCLC. METHODS: The NCDB was queried for untreated clinical stage I to IIIA NSCLC patients diagnosed between 2003 and 2009. The natural history cohort was defined as patients who were recommended to undergo resection but went untreated. RESULTS: We identified 1,693 untreated patients with operable NSCLC. The median survival for clinical stage I, II, and IIIA was 16.6, 9.4, and 8.4 months, respectively. The 5-year Kaplan-Meier estimates of survival for clinical stage I, II, and IIIA NSCLC were 10.1%, 7.3%, and 4.9%, respectively. At each stage (I to IIIA), the survival of untreated operable NSCLC patients was superior to that of untreated NSCLC patients not recommended to undergo resection (nonoperable, p < 0.001). A multivariable Cox regression model identified increasing age, male gender, white (vs black) race, increasing comorbidity, squamous cell or large cell histology, and increasing stage as predictors of decreased survival. CONCLUSIONS: The natural history of operable NSCLC, although poor, varies with clinical stage and is superior to that of nonoperable NSCLC.
BACKGROUND: The survival of untreated non-small cell lung cancer (NSCLC), or the natural history, is an important perspective for patients considering resection for NSCLC. The National Cancer Database (NCDB) allows untreated NSCLCpatients who were recommended to undergo surgical resection (ie, "operable") to be identified. The survival of untreated NSCLCpatients in the NCDB was studied to determine the natural history of operable NSCLC. METHODS: The NCDB was queried for untreated clinical stage I to IIIA NSCLCpatients diagnosed between 2003 and 2009. The natural history cohort was defined as patients who were recommended to undergo resection but went untreated. RESULTS: We identified 1,693 untreated patients with operable NSCLC. The median survival for clinical stage I, II, and IIIA was 16.6, 9.4, and 8.4 months, respectively. The 5-year Kaplan-Meier estimates of survival for clinical stage I, II, and IIIA NSCLC were 10.1%, 7.3%, and 4.9%, respectively. At each stage (I to IIIA), the survival of untreated operable NSCLCpatients was superior to that of untreated NSCLCpatients not recommended to undergo resection (nonoperable, p < 0.001). A multivariable Cox regression model identified increasing age, male gender, white (vs black) race, increasing comorbidity, squamous cell or large cell histology, and increasing stage as predictors of decreased survival. CONCLUSIONS: The natural history of operable NSCLC, although poor, varies with clinical stage and is superior to that of nonoperable NSCLC.
Authors: Olli Helminen; Johanna Valo; Heidi Andersen; Anna Lautamäki; Jari Räsänen; Eero Sihvo Journal: J Thorac Dis Date: 2020-06 Impact factor: 2.895
Authors: Judith Buentzel; Sha Yao; Omar Elakad; Anna-Maria Lois; Jana Brünies; Julia König; Marc Hinterthaner; Bernhard C Danner; Philipp Ströbel; Alexander Emmert; Hanibal Bohnenberger Journal: Medicine (Baltimore) Date: 2019-08 Impact factor: 1.817