Teresa Guerreiro1, Luis Antunes2,3, Joana Bastos4, Alexandra Mayer5, Goncalo Forjaz6,7, AntÓnio Araujo8,9, Carla Nunes10,11. 1. NOVA National School of Public Health, Universidade NOVA de Lisboa, Lisbon, Portugal mt.guerreiro@ensp.unl.pt. 2. Portuguese Institute of Oncology Francisco Gentil, Porto, Portugal. 3. Cancer Epidemiology Group, IPO Porto Research (CI-IPOP), Portuguese Institute of Oncology Francisco Gentil, Porto, Portugal. 4. Portuguese Institute of Oncology Francisco Gentil, Coimbra, Portugal. 5. Portuguese Institute of Oncology Francisco Gentil, Lisbon, Portugal. 6. Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, U.S.A. 7. Azores Oncological Centre, Azores, Portugal. 8. Universitary Hospital Center of Porto, Porto, Portugal. 9. Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal. 10. NOVA National School of Public Health, Universidade NOVA de Lisboa, Lisbon, Portugal. 11. Public Health Research Center, Universidade NOVA de Lisboa, Lisbon, Portugal.
Abstract
BACKGROUND/AIM: This study characterized lung cancer (LC) in Portugal, to capture sex differences, regional variation, and spatial distribution. PATIENTS AND METHODS: Variables: age, sex, vital status, region of residence, degree of urbanization, histologic types and stage at diagnosis. Spatial analyses conducted to identify high (HIC) and low incidence (LIC) clusters. RESULTS: In total, 11,642 cases were diagnosed (76.6% male, 23.4% female), with a similar mean age at diagnosis. There were 23,6% locally advanced and 58.4% metastatic disease cases, with 13.4% alive five years after diagnosis. Non-small-cell LC accounted for 77.3% of which 40.8% was adenocarcinoma and 22.7% was squamous cell carcinoma. Standardized incident rate (IR) was 37.5/105, 65.2/105 in males, and 15.7/105 in females, with four HIC (urban) clusters and four LIC (non-urban). CONCLUSION: This study highlighted the sex differences in incidence, mortality, histology, and geographic distribution of LC in Portugal. Considering the advanced stages and the poor overall survival, understanding sex and geographic differences is important for public health interventions. Copyright
BACKGROUND/AIM: This study characterized lung cancer (LC) in Portugal, to capture sex differences, regional variation, and spatial distribution. PATIENTS AND METHODS: Variables: age, sex, vital status, region of residence, degree of urbanization, histologic types and stage at diagnosis. Spatial analyses conducted to identify high (HIC) and low incidence (LIC) clusters. RESULTS: In total, 11,642 cases were diagnosed (76.6% male, 23.4% female), with a similar mean age at diagnosis. There were 23,6% locally advanced and 58.4% metastatic disease cases, with 13.4% alive five years after diagnosis. Non-small-cell LC accounted for 77.3% of which 40.8% was adenocarcinoma and 22.7% was squamous cell carcinoma. Standardized incident rate (IR) was 37.5/105, 65.2/105 in males, and 15.7/105 in females, with four HIC (urban) clusters and four LIC (non-urban). CONCLUSION: This study highlighted the sex differences in incidence, mortality, histology, and geographic distribution of LC in Portugal. Considering the advanced stages and the poor overall survival, understanding sex and geographic differences is important for public health interventions. Copyright
Authors: Ahmedin Jemal; Kimberly D Miller; Jiemin Ma; Rebecca L Siegel; Stacey A Fedewa; Farhad Islami; Susan S Devesa; Michael J Thun Journal: N Engl J Med Date: 2018-05-24 Impact factor: 91.245
Authors: Manish K Thakur; Julie J Ruterbusch; Ann G Schwartz; Shirish M Gadgeel; Jennifer L Beebe-Dimmer; Antoinette J Wozniak Journal: J Thorac Oncol Date: 2017-10-05 Impact factor: 15.609
Authors: Joshua E Rosen; Hari B Keshava; Xiaopan Yao; Anthony W Kim; Frank C Detterbeck; Daniel J Boffa Journal: Ann Thorac Surg Date: 2016-04-01 Impact factor: 4.330
Authors: Freddie Bray; Jacques Ferlay; Isabelle Soerjomataram; Rebecca L Siegel; Lindsey A Torre; Ahmedin Jemal Journal: CA Cancer J Clin Date: 2018-09-12 Impact factor: 508.702
Authors: Libby Ellis; Laura M Woods; Jacques Estève; Sandra Eloranta; Michel P Coleman; Bernard Rachet Journal: Int J Cancer Date: 2014-06-19 Impact factor: 7.396