Literature DB >> 27038984

Quantification of Long-term Stability and Specific Relief of Lower Urinary Tract Symptoms (LUTS) After Robot-assisted Radical Prostatectomy.

Adam Gordon1, Douglas Skarecky2, Kathryn Osann1, Louis Eichel3, Harleen Dhaliwal1, Blanca Morales1, Thomas Ahlering1.   

Abstract

OBJECTIVE: To assist in preoperative counseling by assessing long-term changes in American Urological Association symptom scores (AUAss) and lower urinary tract symptom (LUTS)-related quality of life (QOL) in patients undergoing robot-assisted radical prostatectomy (RARP).
MATERIALS AND METHODS: RARP was performed on 666 men by one surgeon from 2002 to 2007 at a single institution. AUAss and QOL were queried preoperatively and at 3, 9, 15, 24-48, 60-84, and 96+ months postoperatively. LUTS subgroups were compared pre-/postsurgery using univariate and multivariate statistics.
RESULTS: The mean and median follow-up for all responders was 3.0 and 2.4 years. Pad-free continence at 12 months was 89%. A subset of 174 men reported preoperative and long-term responses; average follow-up was 5.8 years (range 4.0-10.3 years). AUAss for all men declined from baseline to 5 years by 3.7 (8.6 to 4.8) whereas QOL/Bother scores decreased by 0.5 (1.7 to 1.2) (all P < .05). Men with baseline mild LUTS remained clinically unchanged with long-term AUAss. Individuals with moderate and severe preoperative LUTS had marked improvements in AUA and QOL scores (all P ≤ .05).
CONCLUSION: Men with mild LUTS have short-term increases in AUAss but most return to baseline and are stable at 5 years. Benefits were found for men with preoperative moderate and severe LUTS in that 63% had significant QOL improvements and 68% reduced their AUAss to mild LUTS, persisting years after RARP. This study suggests that certain patients with preoperative urinary symptoms and bother may experience improvements in LUTS and associated QOL after RARP.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID: 27038984      PMCID: PMC5929120          DOI: 10.1016/j.urology.2016.03.028

Source DB:  PubMed          Journal:  Urology        ISSN: 0090-4295            Impact factor:   2.649


  30 in total

1.  Radical retropubic prostatectomy reduces symptom scores and improves quality of life in men with moderate and severe lower urinary tract symptoms.

Authors:  E J Schwartz; H Lepor
Journal:  J Urol       Date:  1999-04       Impact factor: 7.450

2.  Variations in international prostate symptom scores, uroflowmetric parameters, and prostate volume after (125)I permanent brachytherapy for localized prostate cancer.

Authors:  Nobumichi Tanaka; Kiyohide Fujimoto; Yoshihiko Hirao; Isao Asakawa; Masatoshi Hasegawa; Noboru Konishi
Journal:  Urology       Date:  2009-04-18       Impact factor: 2.649

3.  The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association.

Authors:  M J Barry; F J Fowler; M P O'Leary; R C Bruskewitz; H L Holtgrewe; W K Mebust; A T Cockett
Journal:  J Urol       Date:  1992-11       Impact factor: 7.450

4.  Impact of robot-assisted radical prostatectomy on lower urinary tract symptoms and predictive factors for symptom changes: a longitudinal study.

Authors:  Jeong Hyun Kim; Yun-Sok Ha; Seong Jin Jeong; Dong-Hyeon Lee; Wun-Jae Kim; Isaac Yi Kim
Journal:  Urology       Date:  2013-02-20       Impact factor: 2.649

5.  Pathophysiology, epidemiology, and natural history of benign prostatic hyperplasia.

Authors:  Herbert Lepor
Journal:  Rev Urol       Date:  2004

6.  Health-related quality of life associated with lower urinary tract symptoms in four countries.

Authors:  C J Girman; S J Jacobsen; T Tsukamoto; F Richard; W M Garraway; P P Sagnier; H A Guess; T Rhodes; P Boyle; M M Lieber
Journal:  Urology       Date:  1998-03       Impact factor: 2.649

7.  Urinary Bother as a Predictor of Postsurgical Changes in Urinary Function After Robotic Radical Prostatectomy.

Authors:  Gregory Murphy; Peter Haddock; Hoyt Doak; Max Jackson; Ryan Dorin; Anoop Meraney; Stuart Kesler; Ilene Staff; Joseph R Wagner
Journal:  Urology       Date:  2015-07-10       Impact factor: 2.649

8.  The impact of cavernosal nerve preservation on continence after robotic radical prostatectomy.

Authors:  Donald L Pick; Kathryn Osann; Douglas Skarecky; Navneet Narula; David S Finley; Thomas E Ahlering
Journal:  BJU Int       Date:  2011-01-18       Impact factor: 5.588

9.  Baseline characteristics predict risk of progression and response to combined medical therapy for benign prostatic hyperplasia (BPH).

Authors:  Michael A Kozminski; John T Wei; Jason Nelson; David M Kent
Journal:  BJU Int       Date:  2014-08-13       Impact factor: 5.588

10.  Comparative analysis of lower urinary tract symptoms and bother in both sexes.

Authors:  Akito Terai; Yoshiyuki Matsui; Kentaro Ichioka; Hiroki Ohara; Naoki Terada; Koji Yoshimura
Journal:  Urology       Date:  2004-03       Impact factor: 2.649

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  3 in total

Review 1.  Changes in quality of life and lower urinary tract symptoms over time in cancer patients after a total prostatectomy: systematic review and meta-analysis.

Authors:  Koji Amano; Kumi Suzuki; Yuri Ito
Journal:  Support Care Cancer       Date:  2021-10-12       Impact factor: 3.359

2.  Lower urinary tract symptoms (LUTS) before and after robotic-assisted laparoscopic prostatectomy: does improvement of LUTS mitigate worsened incontinence after robotic prostatectomy?

Authors:  Lukas Dommer; Jan A Birzele; Khosrow Ahmadi; Mario Rampa; Daniel J Stekhoven; Räto T Strebel
Journal:  Transl Androl Urol       Date:  2019-08

Review 3.  Surgical management of high-risk, localized prostate cancer.

Authors:  Lamont J Wilkins; Jeffrey J Tosoian; Debasish Sundi; Ashley E Ross; Dominic Grimberg; Eric A Klein; Brian F Chapin; Yaw A Nyame
Journal:  Nat Rev Urol       Date:  2020-11-10       Impact factor: 14.432

  3 in total

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