| Literature DB >> 27021370 |
T A Kunts1, K V Karpukhina2, E S Mikhaylova2, I O Marinkin3, N A Varaksin4, A I Autenshlyus2, V V Lyakhovich2.
Abstract
The production of cytokines by peripheral blood cells and biopsy specimens of tumors stimulated by polyclonal activators (PAs) was evaluated in 34 patients with invasive ductal breast carcinoma using enzyme-linked immunosorbent assay (ELISA). Positive correlation between the stimulation index of polyclonal activators (SIPA) for IL-18 production by the tumor and the relative content of poorly differentiated cells was revealed. The latter, in turn, was positively correlated with the numbers of normal and pathologic mitoses and the degree of malignancy. Cancer cells can produce IL-18, which is involved in the process of angiogenesis, stimulates invasion and metastasis. Decrease in SIPA for the production of IL-6 and GCSF by peripheral blood cells could serve as an indicator of malignant progression in invasive ductal breast carcinoma.Entities:
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Year: 2016 PMID： 27021370 DOI： 10.1134/S0012496616010026
Source DB: PubMed Journal: Dokl Biol Sci ISSN： 0012-4966