| Literature DB >> 15225625 |
Yukiko Ishida1, Kiyoshi Migita, Yasumori Izumi, Kazuhiko Nakao, Hiroaki Ida, Atsushi Kawakami, Seigo Abiru, Hiromi Ishibashi, Katsumi Eguchi, Nobuko Ishii.
Abstract
In this study, we examined whether interleukin-18 (IL-18) affects natural killer (NK) cells' migration and matrix metalloproteinases (MMPs) production. We demonstrated that chemotaxis of human NK cells through basement membrane-like Matrigel was augmented by IL-18. As well, IL-18 stimulation induces the production of activated forms of matrix metalloproteinase-2 (MMP-2) as well as the production of pro-MMP-2 from NK cells. We also demonstrated that MT1-MMP expression on human NK cells, which is a major activator of MMP-2, was induced by IL-18 stimulation coordinated with MMP-2 activation. These data suggest that the MT1-MMP/MMP-2 system participates in the degradation of basement membrane components and thus contributes to NK cell migration.Entities:
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Year: 2004 PMID： 15225625 DOI： 10.1016/j.febslet.2004.05.039
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124