Simon Verhulst1, Christine Dalgård2, Carlos Labat3,4, Jeremy D Kark5, Masayuki Kimura6, Kaare Christensen7,8,9, Simon Toupance3,4, Abraham Aviv6, Kirsten O Kyvik10, Athanase Benetos11,12,13. 1. Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands. 2. Department of Public Health, Environmental Medicine, University of Southern Denmark, Odense, Denmark. 3. INSERM, U1116, Vandoeuvre-les-Nancy, France. 4. Université de Lorraine, Nancy, France. 5. Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel. 6. Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA. 7. The Danish Twin Registry, University of Southern Denmark, Odense, Denmark. 8. Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. 9. Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark. 10. Department of Clinical Research, University of Southern Denmark and Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark. 11. INSERM, U1116, Vandoeuvre-les-Nancy, France. a.benetos@chu-nancy.fr. 12. Université de Lorraine, Nancy, France. a.benetos@chu-nancy.fr. 13. Département de Médecine Gériatrique, CHU de Nancy, 54511, Vandoeuvre-les-Nancy, France. a.benetos@chu-nancy.fr.
Abstract
AIMS/HYPOTHESIS: A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance or is a consequence thereof. METHODS: Participants were recruited between 1997 and 2000 through the population-based national Danish Twin Registry to participate in the GEMINAKAR study, a longitudinal evaluation of metabolic disorders and cardiovascular risk factors. Baseline and follow-up measurements of LTL and insulin resistance over an average of 12 years were performed in a subset of the Registry consisting of 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs. RESULTS: Age at baseline examination was 37.4 ± 9.6 (mean ± SD) years. Baseline insulin resistance was not associated with age-dependent changes in LTL (attrition) over the follow-up period, whereas baseline LTL was associated with changes in insulin resistance during this period. The shorter the LTL at baseline, the more pronounced was the increase in insulin resistance over the follow-up period (p < 0.001); this effect was additive to that of BMI. The co-twin with the shorter baseline LTL displayed higher insulin resistance at follow-up than the co-twin with the longer LTL. CONCLUSIONS/ INTERPRETATION: These findings suggest that individuals with short LTL are more likely to develop insulin resistance later in life. By contrast, presence of insulin resistance does not accelerate LTL attrition.
AIMS/HYPOTHESIS: A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance or is a consequence thereof. METHODS:Participants were recruited between 1997 and 2000 through the population-based national Danish Twin Registry to participate in the GEMINAKAR study, a longitudinal evaluation of metabolic disorders and cardiovascular risk factors. Baseline and follow-up measurements of LTL and insulin resistance over an average of 12 years were performed in a subset of the Registry consisting of 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs. RESULTS: Age at baseline examination was 37.4 ± 9.6 (mean ± SD) years. Baseline insulin resistance was not associated with age-dependent changes in LTL (attrition) over the follow-up period, whereas baseline LTL was associated with changes in insulin resistance during this period. The shorter the LTL at baseline, the more pronounced was the increase in insulin resistance over the follow-up period (p < 0.001); this effect was additive to that of BMI. The co-twin with the shorter baseline LTL displayed higher insulin resistance at follow-up than the co-twin with the longer LTL. CONCLUSIONS/ INTERPRETATION: These findings suggest that individuals with short LTL are more likely to develop insulin resistance later in life. By contrast, presence of insulin resistance does not accelerate LTL attrition.
Entities:
Keywords:
Genetics/epidemiology (all); Human; Insulin sensitivity and resistance
Authors: S Ahmad; A Heraclides; Q Sun; T Elgzyri; T Rönn; C Ling; B Isomaa; K-F Eriksson; L Groop; P W Franks; O Hansson Journal: Diabet Med Date: 2012-10 Impact factor: 4.359
Authors: Klelia D Salpea; Philippa J Talmud; Jackie A Cooper; Cecilia G Maubaret; Jeffrey W Stephens; Kavin Abelak; Steve E Humphries Journal: Atherosclerosis Date: 2009-10-06 Impact factor: 5.162
Authors: Troels Steenstrup; Jacob V B Hjelmborg; Jeremy D Kark; Kaare Christensen; Abraham Aviv Journal: Nucleic Acids Res Date: 2013-05-13 Impact factor: 16.971
Authors: Athanase Benetos; Christine Dalgård; Carlos Labat; Jeremy D Kark; Simon Verhulst; Kaare Christensen; Masayuki Kimura; Kent Horvath; Kirsten Ohm Kyvik; Abraham Aviv Journal: Int J Epidemiol Date: 2014-07-23 Impact factor: 7.196
Authors: Atoll Goswami; Nafiul Huda; Tahirah Yasmin; Md Ismail Hosen; A K M Mahbub Hasan; A H M Nurun Nabi Journal: Mol Biol Rep Date: 2021-01-03 Impact factor: 2.316
Authors: Ashley E Mason; Frederick M Hecht; Jennifer J Daubenmier; David A Sbarra; Jue Lin; Patricia J Moran; Samantha G Schleicher; Michael Acree; Aric A Prather; Elissa S Epel Journal: Psychosom Med Date: 2018-09 Impact factor: 4.312
Authors: Dóra Révész; Josine E Verhoeven; Martin Picard; Jue Lin; Stephen Sidney; Elissa S Epel; Brenda W J H Penninx; Eli Puterman Journal: J Clin Endocrinol Metab Date: 2018-01-01 Impact factor: 5.958
Authors: Janet M Wojcicki; Robert H Lustig; Laurie M Jacobs; Ashley E Mason; Alison Hartman; Cindy Leung; Kimber Stanhope; Jue Lin; Laura A Schmidt; Elissa S Epel Journal: Curr Dev Nutr Date: 2021-05-26