Ashley E Mason1, Frederick M Hecht, Jennifer J Daubenmier, David A Sbarra, Jue Lin, Patricia J Moran, Samantha G Schleicher, Michael Acree, Aric A Prather, Elissa S Epel. 1. From the UCSF Department of Psychiatry (Mason, Schleicher, Prather, Epel), Center for Health and Community, San Francisco, California; UCSF Osher Center for Integrative Medicine (Mason, Hecht, Moran, Schleicher, Acree, Epel), San Francisco, California; Department of Health Education (Daubenmier), SF State University, Institute of Holistic Health Studies, San Francisco, California; Department of Psychology (Sbarra), The University of Arizona, Tucson; and UCSF Department of Biochemistry and Biophysics (Lin), San Francisco, California.
Abstract
OBJECTIVE: The aim of the study was to determine, within a weight loss clinical trial for obesity, the impact of intervention arm, weight change, and weight loss maintenance on telomere length (TL). METHODS: Adults (N = 194) with a body mass index between 30 and 45 were randomized to a 5.5-month weight loss program with (n = 100) or without (n = 94) mindfulness training and identical diet-exercise guidelines. We assessed TL at baseline and 3-, 6-, and 12-month postbaseline in immune cell populations (primarily in peripheral blood mononuclear cells [PBMCs], but also in granulocytes and T and B lymphocytes). We defined weight loss maintenance as having lost at least 5% or 10% of body weight (tested in separate models) from preintervention to postintervention, and having maintained this loss at 12 months. We predicted that greater weight loss and weight loss maintenance would be associated with TL lengthening. RESULTS: Neither weight loss intervention significantly predicted TL change nor did amount of weight change, at any time point. Across all participants, weight loss maintenance of at least 10% was associated with longer PBMC TL (b = 239.08, 95% CI = 0.92 to 477.25, p = .049), CD8+ TL (b = 417.26, 95% CI = 58.95 to 775.57, p = .023), and longer granulocyteTL (b = 191.56, 95% CI = -4.23 to 387.35, p = .055) at 12 months after accounting for baseline TL. Weight loss maintenance of 5% or more was associated with longer PBMC TL (b = 163.32, 95% CI = 4.00 to 320.62, p = .045) at 12 months after accounting for baseline TL. These tests should be interpreted in light of corrections for multiple tests. CONCLUSIONS: Among individuals with obesity, losing and maintaining a weight loss of 10% or more may lead to TL lengthening, which may portend improved immune and metabolic function. TL lengthening in this study is of unknown duration beyond 12 months and requires further study. TRIAL REGISTRATION: Clinicaltrials.govidentifierNCT00960414; Open Science Framework (OSF) preregistration: https://osf.io/t3r2g/.
RCT Entities:
OBJECTIVE: The aim of the study was to determine, within a weight loss clinical trial for obesity, the impact of intervention arm, weight change, and weight loss maintenance on telomere length (TL). METHODS: Adults (N = 194) with a body mass index between 30 and 45 were randomized to a 5.5-month weight loss program with (n = 100) or without (n = 94) mindfulness training and identical diet-exercise guidelines. We assessed TL at baseline and 3-, 6-, and 12-month postbaseline in immune cell populations (primarily in peripheral blood mononuclear cells [PBMCs], but also in granulocytes and T and B lymphocytes). We defined weight loss maintenance as having lost at least 5% or 10% of body weight (tested in separate models) from preintervention to postintervention, and having maintained this loss at 12 months. We predicted that greater weight loss and weight loss maintenance would be associated with TL lengthening. RESULTS: Neither weight loss intervention significantly predicted TL change nor did amount of weight change, at any time point. Across all participants, weight loss maintenance of at least 10% was associated with longer PBMC TL (b = 239.08, 95% CI = 0.92 to 477.25, p = .049), CD8+ TL (b = 417.26, 95% CI = 58.95 to 775.57, p = .023), and longer granulocyte TL (b = 191.56, 95% CI = -4.23 to 387.35, p = .055) at 12 months after accounting for baseline TL. Weight loss maintenance of 5% or more was associated with longer PBMC TL (b = 163.32, 95% CI = 4.00 to 320.62, p = .045) at 12 months after accounting for baseline TL. These tests should be interpreted in light of corrections for multiple tests. CONCLUSIONS: Among individuals with obesity, losing and maintaining a weight loss of 10% or more may lead to TL lengthening, which may portend improved immune and metabolic function. TL lengthening in this study is of unknown duration beyond 12 months and requires further study. TRIAL REGISTRATION: Clinicaltrials.govidentifierNCT00960414; Open Science Framework (OSF) preregistration: https://osf.io/t3r2g/.
Authors: Ashley E Mason; Elissa S Epel; Kirstin Aschbacher; Robert H Lustig; Michael Acree; Jean Kristeller; Michael Cohn; Mary Dallman; Patricia J Moran; Peter Bacchetti; Barbara Laraia; Frederick M Hecht; Jennifer Daubenmier Journal: Appetite Date: 2016-02-08 Impact factor: 3.868
Authors: Jennifer Daubenmier; Patricia J Moran; Jean Kristeller; Michael Acree; Peter Bacchetti; Margaret E Kemeny; Mary Dallman; Robert H Lustig; Carl Grunfeld; Douglas F Nixon; Jeffrey M Milush; Veronica Goldman; Barbara Laraia; Kevin D Laugero; Leslie Woodhouse; Elissa S Epel; Frederick M Hecht Journal: Obesity (Silver Spring) Date: 2016-03-09 Impact factor: 5.002
Authors: Laura K M Han; Josine E Verhoeven; Audrey R Tyrka; Brenda W J H Penninx; Owen M Wolkowitz; Kristoffer N T Månsson; Daniel Lindqvist; Marco P Boks; Dóra Révész; Synthia H Mellon; Martin Picard Journal: Psychoneuroendocrinology Date: 2019-04-05 Impact factor: 4.905
Authors: Sheri J Hartman; Lauren S Weiner; Loki Natarajan; Dorothy D Sears; Barton W Palmer; Barbara Parker; Tim Ahles; Melinda L Irwin; Kaylene Au Journal: Contemp Clin Trials Date: 2021-01-24 Impact factor: 2.226
Authors: Janet M Wojcicki; Robert H Lustig; Laurie M Jacobs; Ashley E Mason; Alison Hartman; Cindy Leung; Kimber Stanhope; Jue Lin; Laura A Schmidt; Elissa S Epel Journal: Curr Dev Nutr Date: 2021-05-26