| Literature DB >> 27008888 |
Mitchell J Machiela1, Qing Lan2, Susan L Slager3, Roel C H Vermeulen4, Lauren R Teras5, Nicola J Camp6, James R Cerhan3, John J Spinelli7, Sophia S Wang8, Alexandra Nieters9, Joseph Vijai10, Meredith Yeager11, Zhaoming Wang11, Hervé Ghesquières12, James McKay13, Lucia Conde14, Paul I W de Bakker15, David G Cox16, Laurie Burdett11, Alain Monnereau17, Christopher R Flowers18, Anneclaire J De Roos19, Angela R Brooks-Wilson20, Graham G Giles21, Mads Melbye22, Jian Gu23, Rebecca D Jackson24, Eleanor Kane25, Mark P Purdue26, Claire M Vajdic27, Demetrius Albanes2, Rachel S Kelly28, Mariagrazia Zucca29, Kimberly A Bertrand30, Anne Zeleniuch-Jacquotte31, Charles Lawrence32, Amy Hutchinson11, Degui Zhi33, Thomas M Habermann10, Brian K Link34, Anne J Novak10, Ahmet Dogan35, Yan W Asmann36, Mark Liebow10, Carrie A Thompson10, Stephen M Ansell10, Thomas E Witzig10, Hervé Tilly37, Corinne Haioun38, Thierry J Molina39, Henrik Hjalgrim40, Bengt Glimelius41, Hans-Olov Adami42, Göran Roos43, Paige M Bracci44, Jacques Riby14, Martyn T Smith45, Elizabeth A Holly44, Wendy Cozen46, Patricia Hartge2, Lindsay M Morton2, Richard K Severson47, Lesley F Tinker48, Kari E North49, Nikolaus Becker50, Yolanda Benavente51, Paolo Boffetta52, Paul Brennan13, Lenka Foretova53, Marc Maynadie54, Anthony Staines55, Tracy Lightfoot25, Simon Crouch25, Alex Smith25, Eve Roman25, W Ryan Diver5, Kenneth Offit10, Andrew Zelenetz10, Robert J Klein56, Danylo J Villano10, Tongzhang Zheng57, Yawei Zhang57, Theodore R Holford58, Jenny Turner59, Melissa C Southey60, Jacqueline Clavel61, Jarmo Virtamo62, Stephanie Weinstein2, Elio Riboli63, Paolo Vineis64, Rudolph Kaaks50, Heiner Boeing65, Anne Tjønneland66, Emanuele Angelucci67, Simonetta Di Lollo68, Marco Rais69, Immaculata De Vivo30, Edward Giovannucci70, Peter Kraft71, Jinyan Huang72, Baoshan Ma73, Yuanqing Ye23, Brian C H Chiu74, Liming Liang71, Ju-Hyun Park75, Charles C Chung2, Dennis D Weisenburger76, Joseph F Fraumeni2, Gilles Salles77, Martha Glenn6, Lisa Cannon-Albright6, Karen Curtin6, Xifeng Wu23, Karin E Smedby78, Silvia de Sanjose51, Christine F Skibola14, Sonja I Berndt2, Brenda M Birmann79, Stephen J Chanock2, Nathaniel Rothman2.
Abstract
Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82,P-value = 8.5 × 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51,P-value = 4.0 × 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk. Published by Oxford University Press 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.Entities:
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Year: 2016 PMID： 27008888 PMCID： PMC4854019 DOI： 10.1093/hmg/ddw027
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 5.121