| Literature DB >> 25279986 |
Christine F Skibola1, Sonja I Berndt2, Joseph Vijai3, Lucia Conde4, Zhaoming Wang5, Meredith Yeager5, Paul I W de Bakker6, Brenda M Birmann7, Claire M Vajdic8, Jia-Nee Foo9, Paige M Bracci10, Roel C H Vermeulen11, Susan L Slager12, Silvia de Sanjose13, Sophia S Wang14, Martha S Linet2, Gilles Salles15, Qing Lan2, Gianluca Severi16, Henrik Hjalgrim17, Tracy Lightfoot18, Mads Melbye19, Jian Gu20, Hervé Ghesquières21, Brian K Link22, Lindsay M Morton2, Elizabeth A Holly10, Alex Smith18, Lesley F Tinker23, Lauren R Teras24, Anne Kricker25, Nikolaus Becker26, Mark P Purdue2, John J Spinelli27, Yawei Zhang28, Graham G Giles29, Paolo Vineis30, Alain Monnereau31, Kimberly A Bertrand32, Demetrius Albanes2, Anne Zeleniuch-Jacquotte33, Attilio Gabbas34, Charles C Chung2, Laurie Burdett5, Amy Hutchinson5, Charles Lawrence35, Rebecca Montalvan35, Liming Liang36, Jinyan Huang37, Baoshan Ma38, Jianjun Liu9, Hans-Olov Adami39, Bengt Glimelius40, Yuanqing Ye20, Grzegorz S Nowakowski12, Ahmet Dogan41, Carrie A Thompson42, Thomas M Habermann42, Anne J Novak42, Mark Liebow42, Thomas E Witzig42, George J Weiner22, Maryjean Schenk43, Patricia Hartge2, Anneclaire J De Roos44, Wendy Cozen45, Degui Zhi46, Nicholas K Akers47, Jacques Riby4, Martyn T Smith47, Mortimer Lacher3, Danylo J Villano3, Ann Maria3, Eve Roman18, Eleanor Kane18, Rebecca D Jackson48, Kari E North49, W Ryan Diver24, Jenny Turner50, Bruce K Armstrong25, Yolanda Benavente13, Paolo Boffetta51, Paul Brennan52, Lenka Foretova53, Marc Maynadie54, Anthony Staines55, James McKay56, Angela R Brooks-Wilson57, Tongzhang Zheng28, Theodore R Holford58, Saioa Chamosa59, Rudolph Kaaks26, Rachel S Kelly60, Bodil Ohlsson61, Ruth C Travis62, Elisabete Weiderpass63, Jacqueline Clavel64, Edward Giovannucci65, Peter Kraft36, Jarmo Virtamo66, Patrizio Mazza67, Pierluigi Cocco34, Maria Grazia Ennas68, Brian C H Chiu69, Joseph F Fraumeni2, Alexandra Nieters70, Kenneth Offit3, Xifeng Wu20, James R Cerhan12, Karin E Smedby71, Stephen J Chanock2, Nathaniel Rothman2.
Abstract
Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [OR(per-allele)] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (OR(per-allele) = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.Entities:
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Year: 2014 PMID： 25279986 PMCID： PMC4185120 DOI： 10.1016/j.ajhg.2014.09.004
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.043