Literature DB >> 27007675

A biased view toward celiac disease.

J Rossjohn1,2,3, F Koning4.   

Abstract

Celiac disease is an autoimmune-like disorder that is triggered by dietary gluten and has a strong genetic association with the human leukocyte antigen locus, specifically, HLA-DQ2.5/DQ8. Here, Dahai-Koirala et al. apply ex vivo single-cell sequencing of TCRs from celiac disease patients, and show that biased T-cell receptor usage underpins the response to two gluten epitopes, which has implications for disease pathogenesis, diagnosis, and treatment.

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Year:  2016        PMID： 27007675     DOI： 10.1038/mi.2016.17

Source DB:  PubMed          Journal:  Mucosal Immunol        ISSN： 1933-0219            Impact factor:   7.313


  17 in total

1.  Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease.

Authors:  Jason A Tye-Din; Jessica A Stewart; James A Dromey; Tim Beissbarth; David A van Heel; Arthur Tatham; Kate Henderson; Stuart I Mannering; Carmen Gianfrani; Derek P Jewell; Adrian V S Hill; James McCluskey; Jamie Rossjohn; Robert P Anderson
Journal:  Sci Transl Med       Date:  2010-07-21       Impact factor: 17.956

Review 2.  Integration of genetic and immunological insights into a model of celiac disease pathogenesis.

Authors:  Valérie Abadie; Ludvig M Sollid; Luis B Barreiro; Bana Jabri
Journal:  Annu Rev Immunol       Date:  2011       Impact factor: 28.527

3.  Posttranslational modification of gluten shapes TCR usage in celiac disease.

Authors:  Shuo-Wang Qiao; Melinda Ráki; Kristin S Gunnarsen; Geir-Åge Løset; Knut E A Lundin; Inger Sandlie; Ludvig M Sollid
Journal:  J Immunol       Date:  2011-08-17       Impact factor: 5.422

4.  Determinants of gliadin-specific T cell selection in celiac disease.

Authors:  Jan Petersen; Jeroen van Bergen; Khai Lee Loh; Yvonne Kooy-Winkelaar; Dennis X Beringer; Allan Thompson; Sjoerd F Bakker; Chris J J Mulder; Kristin Ladell; James E McLaren; David A Price; Jamie Rossjohn; Hugh H Reid; Frits Koning
Journal:  J Immunol       Date:  2015-05-06       Impact factor: 5.422

5.  T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.

Authors:  Jan Petersen; Veronica Montserrat; Jorge R Mujico; Khai Lee Loh; Dennis X Beringer; Menno van Lummel; Allan Thompson; M Luisa Mearin; Joachim Schweizer; Yvonne Kooy-Winkelaar; Jeroen van Bergen; Jan W Drijfhout; Wan-Ting Kan; Nicole L La Gruta; Robert P Anderson; Hugh H Reid; Frits Koning; Jamie Rossjohn
Journal:  Nat Struct Mol Biol       Date:  2014-04-28       Impact factor: 15.369

6.  Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease.

Authors:  Sophie E Broughton; Jan Petersen; Alex Theodossis; Stephen W Scally; Khai Lee Loh; Allan Thompson; Jeroen van Bergen; Yvonne Kooy-Winkelaar; Kate N Henderson; Travis Beddoe; Jason A Tye-Din; Stuart I Mannering; Anthony W Purcell; James McCluskey; Robert P Anderson; Frits Koning; Hugh H Reid; Jamie Rossjohn
Journal:  Immunity       Date:  2012-10-11       Impact factor: 31.745

7.  Biased usage and preferred pairing of α- and β-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease.

Authors:  Shuo-Wang Qiao; Asbjørn Christophersen; Knut E A Lundin; Ludvig M Sollid
Journal:  Int Immunol       Date:  2013-09-13       Impact factor: 4.823

8.  TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage.

Authors:  S Dahal-Koirala; L F Risnes; A Christophersen; V K Sarna; K Ea Lundin; L M Sollid; S W Qiao
Journal:  Mucosal Immunol       Date:  2016-02-03       Impact factor: 7.313

9.  Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues.

Authors:  Helene Arentz-Hansen; Stephen N McAdam; Øyvind Molberg; Burkhard Fleckenstein; Knut E A Lundin; Thomas J D Jørgensen; Günther Jung; Peter Roepstorff; Ludvig M Sollid
Journal:  Gastroenterology       Date:  2002-09       Impact factor: 22.682

Review 10.  Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules.

Authors:  Ludvig M Sollid; Shuo-Wang Qiao; Robert P Anderson; Carmen Gianfrani; Frits Koning
Journal:  Immunogenetics       Date:  2012-02-10       Impact factor: 2.846
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  2 in total

1.  A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease.

Authors:  Yi Tian Ting; Shiva Dahal-Koirala; Hui Shi Keshia Kim; Shuo-Wang Qiao; Ralf S Neumann; Knut E A Lundin; Jan Petersen; Hugh H Reid; Ludvig M Sollid; Jamie Rossjohn
Journal:  Proc Natl Acad Sci U S A       Date:  2020-01-23       Impact factor: 11.205

Review 2.  T Cells in Celiac Disease.

Authors:  Bana Jabri; Ludvig M Sollid
Journal:  J Immunol       Date:  2017-04-15       Impact factor: 5.422
  2 in total

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