| Literature DB >> 28373482 |
Bana Jabri1,2,3, Ludvig M Sollid4.
Abstract
Celiac disease is a human T cell-mediated autoimmune-like disorder caused by exposure to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T cell responses directed against an exogenous Ag can cause an autoreactive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells. Furthermore, this review will examine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celiac disease.Entities:
Mesh:
Year: 2017 PMID: 28373482 PMCID: PMC5426360 DOI: 10.4049/jimmunol.1601693
Source DB: PubMed Journal: J Immunol ISSN: 0022-1767 Impact factor: 5.422