Literature DB >> 27006699

Management of epilepsy during pregnancy: an update.

Sima I Patel1, Page B Pennell2.   

Abstract

The clinical management of women with epilepsy on antiepileptic drugs (AEDs) during pregnancy presents unique challenges. The goal of treatment is optimal seizure control with minimal in utero fetal exposure to AEDs in an effort to reduce the risk of structural and neurodevelopmental teratogenic effects. This paper reviews the following key issues pertaining to women with epilepsy during pregnancy: AED pharmacokinetics; clinical management of AEDs; seizure frequency; major congenital malformation; neurodevelopmental outcomes; perinatal complications; and breast feeding.

Entities:  

Keywords:  antiepileptic drugs; breast feeding; epilepsy; neurocognitive development; perinatal outcomes; pregnancy; seizures; teratogenicity

Year:  2015        PMID： 27006699      PMCID： PMC4784252          DOI： 10.1177/1756285615623934

Source DB:  PubMed          Journal:  Ther Adv Neurol Disord        ISSN： 1756-2856            Impact factor:   6.570


  45 in total

1.  Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register.

Authors:  J Morrow; A Russell; E Guthrie; L Parsons; I Robertson; R Waddell; B Irwin; R C McGivern; P J Morrison; J Craig
Journal:  J Neurol Neurosurg Psychiatry       Date:  2005-09-12       Impact factor: 10.154

2.  Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers.

Authors:  E Campbell; F Kennedy; A Russell; W H Smithson; L Parsons; P J Morrison; B Liggan; B Irwin; N Delanty; S J Hunt; J Craig; J Morrow
Journal:  J Neurol Neurosurg Psychiatry       Date:  2014-01-20       Impact factor: 10.154

3.  Mortality and Morbidity During Delivery Hospitalization Among Pregnant Women With Epilepsy in the United States.

Authors:  Sarah C MacDonald; Brian T Bateman; Thomas F McElrath; Sonia Hernández-Díaz
Journal:  JAMA Neurol       Date:  2015-09       Impact factor: 18.302

4.  Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry.

Authors:  Torbjörn Tomson; Dina Battino; Erminio Bonizzoni; John Craig; Dick Lindhout; Anne Sabers; Emilio Perucca; Frank Vajda
Journal:  Lancet Neurol       Date:  2011-06-05       Impact factor: 44.182

5.  Effects of breastfeeding in children of women taking antiepileptic drugs.

Authors:  K J Meador; G A Baker; N Browning; J Clayton-Smith; D T Combs-Cantrell; M Cohen; L A Kalayjian; A Kanner; J D Liporace; P B Pennell; M Privitera; D W Loring
Journal:  Neurology       Date:  2010-11-24       Impact factor: 9.910

6.  Proactive pre-conception counselling for women with epilepsy-is it effective?

Authors:  T Betts; C Fox
Journal:  Seizure       Date:  1999-09       Impact factor: 3.184

7.  Effects of maternal epilepsy and antiepileptic drug use during pregnancy on perinatal health in offspring: nationwide, retrospective cohort study in Finland.

Authors:  Miia Artama; Mika Gissler; Heli Malm; Annukka Ritvanen
Journal:  Drug Saf       Date:  2013-05       Impact factor: 5.606

8.  Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study.

Authors:  Kimford J Meador; Gus A Baker; Nancy Browning; Morris J Cohen; Rebecca L Bromley; Jill Clayton-Smith; Laura A Kalayjian; Andres Kanner; Joyce D Liporace; Page B Pennell; Michael Privitera; David W Loring
Journal:  Lancet Neurol       Date:  2013-01-23       Impact factor: 44.182

Review 9.  Basic obstetric pharmacology.

Authors:  Yang Zhao; Mary F Hebert; Raman Venkataramanan
Journal:  Semin Perinatol       Date:  2014-10-01       Impact factor: 3.300

10.  Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency.

Authors:  P B Pennell; L Peng; D J Newport; J C Ritchie; A Koganti; D K Holley; M Newman; Z N Stowe
Journal:  Neurology       Date:  2007-11-28       Impact factor: 9.910
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  14 in total

1.  Effects of lacosamide "a novel antiepileptic drug" in the early stages of chicken embryo development.

Authors:  Mesut Mete; Beyhan Gurcu; Fatih Collu; Ulkun Unlu Unsal; Yusuf Kurtulus Duransoy; Mehmet Ibrahim Tuglu; Mehmet Selcuki
Journal:  Childs Nerv Syst       Date:  2016-07-29       Impact factor: 1.475

2.  Contraception, pregnancy, and peripartum experiences among women with epilepsy in Bhutan.

Authors:  Sheliza Halani; Lhab Tshering; Esther Bui; Sarah J Clark; Sara J Grundy; Tandin Pem; Sonam Lhamo; Ugyen Dema; Damber K Nirola; Chencho Dorji; Farrah J Mateen
Journal:  Epilepsy Res       Date:  2017-10-18       Impact factor: 3.045

3.  Pharmacotherapies for the Treatment of Alcohol Use Disorders During Pregnancy: Time to Reconsider?

Authors:  Erin Kelty; Mishka Terplan; Melanie Greenland; David Preen
Journal:  Drugs       Date:  2021-04-08       Impact factor: 9.546

Review 4.  Recent advances in epilepsy.

Authors:  Mark Manford
Journal:  J Neurol       Date:  2017-01-24       Impact factor: 4.849

Review 5.  Placental control of drug delivery.

Authors:  Sanaalarab Al-Enazy; Shariq Ali; Norah Albekairi; Marwa El-Tawil; Erik Rytting
Journal:  Adv Drug Deliv Rev       Date:  2016-08-12       Impact factor: 15.470

6.  Antiepileptic drug use among women from the Taiwanese Registry of Epilepsy and Pregnancy: Obstetric complications and fetal malformation outcomes.

Authors:  Chang Ching Yeh; Eric C Lussier; Yi-Ting Sun; Tzuo-Yun Lan; Hsiang-Yu Yu; Tung-Yao Chang
Journal:  PLoS One       Date:  2017-12-18       Impact factor: 3.240

Review 7.  The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy.

Authors:  Edward Beamer; Wolfgang Fischer; Tobias Engel
Journal:  Front Neurosci       Date:  2017-02-02       Impact factor: 4.677

Review 8.  A review of vagus nerve stimulation as a therapeutic intervention.

Authors:  Rhaya L Johnson; Christopher G Wilson
Journal:  J Inflamm Res       Date:  2018-05-16

9.  Optimizing responses to drug safety signals in pregnancy: the example of dolutegravir and neural tube defects.

Authors:  Lynne M Mofenson; Anton L Pozniak; Jacque Wambui; Elliot Raizes; Andrea Ciaranello; Polly Clayden; Peter Ehrenkranz; Ade Fakoya; Andrew Hill; Saye Khoo; Imelda Mahaka; Surbhi Modi; Cynthia Moore; Andrew Phillips; George Siberry; Kenly Sikwese; Claire Thorne; Heather D Watts; Meg Doherty; Nathan P Ford
Journal:  J Int AIDS Soc       Date:  2019-07       Impact factor: 5.396

10.  Antiepileptic Drugs Usage in Pregnant Women with Epilepsy in Saudi Arabia.

Authors:  Hussein Algahtani; Bader Shirah; Faisal Alkahtani; Khalid Alrefaei; Abdulrahman Alamri; Ahmed Aldarmahi
Journal:  J Epilepsy Res       Date:  2019-12-31
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