Zohaib Akram1,2, Syarida Hasnur Safii1, Rathna Devi Vaithilingam1, Nor Adinar Baharuddin1, Fawad Javed3, Fahim Vohra4. 1. Department of Restorative Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia. 2. Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, 75600, Pakistan. 3. Division of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, 14620, USA. 4. Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, PO-Box-60169, Riyadh, 11545, Saudi Arabia. fahimvohra@yahoo.com.
Abstract
OBJECTIVE: There is a controversy over the influence of obesity on the periodontal treatment outcome in patients with chronic periodontitis (CP). The aim of the present systematic review was to evaluate the efficacy of non-surgical periodontal therapy (NSPT) in the management of CP among obese and non-obese patients. MATERIALS AND METHODS: The addressed focused question was "What is the efficacy, of NSPT with respect to clinical, radiographic, biochemical, microbiological, and patient-centered outcomes in obese as compared to non-obese chronic periodontitis patients?" Databases were searched from 1977 up to and including December 2014 using relevant key indexing terms. Unpublished data, experimental studies, letters to the editor, review articles, case reports, and commentaries were excluded. Meta-analysis of three studies was performed. RESULTS: Five clinical studies were included. The total number of patients ranged between 30 and 260 individuals. The mean age of patients was between 42.5 and 48.8 years. In three studies, the clinical periodontal parameters (plaque index (PI), gingival bleeding index (GBI), periodontal pocket depth (PPD), and clinical attachment loss (CAL)) in obese and non-obese patients following NSPT was comparable. Meta-analysis of PPD and CAL among obese and non-obese subjects showed comparable outcomes (PPD P = 0.91, I (2) 67.36 %; CAL P = 0.87, I (2) 77.16 %). However, in three studies, NSPT resulted in a significantly better clinical periodontal outcome among non-obese subjects than obese subjects. The difference in the levels of serum pro-inflammatory cytokine levels (IL-1β, IL-6, TNF-α, IFN-γ, leptin, adiponectin, and CRP) among obese and non-obese patients following treatment for CP was inconsistent. CONCLUSION: It remains unclear whether NSPT has a significantly higher impact on the clinical periodontal outcomes in obese patients than in non-obese patients with chronic periodontitis, given that the number of selected studies was relatively low and the reported findings were inconsistent. CLINICAL RELEVANCE: Although the effect of obesity on the outcome of NSPT still remains unclear, nevertheless clinicians are prompted to manage obesity prior to and during periodontal treatment.
OBJECTIVE: There is a controversy over the influence of obesity on the periodontal treatment outcome in patients with chronic periodontitis (CP). The aim of the present systematic review was to evaluate the efficacy of non-surgical periodontal therapy (NSPT) in the management of CP among obese and non-obesepatients. MATERIALS AND METHODS: The addressed focused question was "What is the efficacy, of NSPT with respect to clinical, radiographic, biochemical, microbiological, and patient-centered outcomes in obese as compared to non-obese chronic periodontitispatients?" Databases were searched from 1977 up to and including December 2014 using relevant key indexing terms. Unpublished data, experimental studies, letters to the editor, review articles, case reports, and commentaries were excluded. Meta-analysis of three studies was performed. RESULTS: Five clinical studies were included. The total number of patients ranged between 30 and 260 individuals. The mean age of patients was between 42.5 and 48.8 years. In three studies, the clinical periodontal parameters (plaque index (PI), gingival bleeding index (GBI), periodontal pocket depth (PPD), and clinical attachment loss (CAL)) in obese and non-obesepatients following NSPT was comparable. Meta-analysis of PPD and CAL among obese and non-obese subjects showed comparable outcomes (PPD P = 0.91, I (2) 67.36 %; CAL P = 0.87, I (2) 77.16 %). However, in three studies, NSPT resulted in a significantly better clinical periodontal outcome among non-obese subjects than obese subjects. The difference in the levels of serum pro-inflammatory cytokine levels (IL-1β, IL-6, TNF-α, IFN-γ, leptin, adiponectin, and CRP) among obese and non-obesepatients following treatment for CP was inconsistent. CONCLUSION: It remains unclear whether NSPT has a significantly higher impact on the clinical periodontal outcomes in obesepatients than in non-obesepatients with chronic periodontitis, given that the number of selected studies was relatively low and the reported findings were inconsistent. CLINICAL RELEVANCE: Although the effect of obesity on the outcome of NSPT still remains unclear, nevertheless clinicians are prompted to manage obesity prior to and during periodontal treatment.
Authors: Tadkamol Krongbaramee; Min Zhu; Qingwen Qian; Zeyuan Zhang; Steven Eliason; Yi Shu; Fang Qian; Adil Akkouch; Dan Su; Brad A Amendt; Ling Yang; Liu Hong Journal: Mol Ther Nucleic Acids Date: 2021-02-04 Impact factor: 8.886
Authors: Samara S Basher; R Saub; R D Vaithilingam; S H Safii; Aqil M Daher; F H Al-Bayaty; N A Baharuddin Journal: Health Qual Life Outcomes Date: 2017-11-21 Impact factor: 3.186