Su-Lan Zhong1, Jia Ni, Qiao-Xue Chai, Lei Chen, Jin-Cai Zhang. 1. Department of Endodontics, Affiliated Hospital of Stomatology of Southern Medical University/Guangdong Provincial Stomatological Hospital, Guangzhou 510515, China. E-mail: zhongsulancy@163.com.
Abstract
OBJECTIVE: To investigate the effects of non-surgical periodontal therapy on serum inflammatory factors and metabolism levels in obese rats with experimental periodontitis. METHODS: Sixteen obese rats with experimental periodontitis were randomly divided into treatment group and control group with non-surgical periodontal therapy and no treatment, respectively. Oral glucose tolerance test was performed before treatment and 2 weeks after the treatment. All the rats were sacrificed 2 weeks after treatment and the orbital vein blood was taken to detect fasting blood glucose, fasting insulin, and serum level of C-reactive protein (CRP). Results Two weeks after periodontal treatment, fasting blood glucose (t=2.445, P=0.034) and beta cell function index (t=-2.543, P=0.027) were significantly lower in the treatment group than in the control group. Compared with those in the control group, CRP level (t=2.388, P=0.028) and the area under the curve in the oral glucose tolerance test (t=12.053, P=0.000) decreased significantly in the treatment group. CONCLUSION: Non-surgical periodontal treatment can reduce serum CRP level and improve glucose metabolism in obese rats.
OBJECTIVE: To investigate the effects of non-surgical periodontal therapy on serum inflammatory factors and metabolism levels in obeserats with experimental periodontitis. METHODS: Sixteen obeserats with experimental periodontitis were randomly divided into treatment group and control group with non-surgical periodontal therapy and no treatment, respectively. Oral glucose tolerance test was performed before treatment and 2 weeks after the treatment. All the rats were sacrificed 2 weeks after treatment and the orbital vein blood was taken to detect fasting blood glucose, fasting insulin, and serum level of C-reactive protein (CRP). Results Two weeks after periodontal treatment, fasting blood glucose (t=2.445, P=0.034) and beta cell function index (t=-2.543, P=0.027) were significantly lower in the treatment group than in the control group. Compared with those in the control group, CRP level (t=2.388, P=0.028) and the area under the curve in the oral glucose tolerance test (t=12.053, P=0.000) decreased significantly in the treatment group. CONCLUSION: Non-surgical periodontal treatment can reduce serum CRP level and improve glucose metabolism in obeserats.
Authors: Emrah Koçak; Mehmet Sağlam; Seyit Ali Kayış; Niyazi Dündar; Levent Kebapçılar; Bruno G Loos; Sema S Hakkı Journal: Lasers Med Sci Date: 2016-01-11 Impact factor: 3.161