Kayla Miller1, Suraj Dixit1,2, Amy-Lee Bredlau3,4, Alfred Moore1,2, Emilie McKinnon2, Ann-Marie Broome1,2,4. 1. Department of Radiology & Radiological Sciences, Medical University of South Carolina, 68 President Street, MSC 120/BEB 213, Charleston, SC 29425, USA. 2. Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC 29425, USA. 3. Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA. 4. Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Abstract
AIM: Glioblastoma multiforme is a devastating disease with no curative options due to the difficulty in achieving sufficient quantities of effective chemotherapies into the tumor past the blood-brain barrier. Micelles loaded with temozolomide (TMZ) were designed to increase the delivery of this drug into the brain. MATERIALS & METHODS: pH-responsive micelles composed of distearoyl phosphoethanolamine-PEG-2000-amine and N-palmitoyl homocysteine were surface-functionalized with PDGF peptide and Dylight 680 fluorophore. RESULTS & CONCLUSION: PDGF-micelles containing TMZ have specific uptake and increased killing in glial cells compared with untargeted micelles. In vivo studies demonstrated selective accumulation of PDGF-micelles containing TMZ in orthotopic gliomas implanted in mice. Targeted micelle-based drug carrier systems hold potential for delivery of a wide variety of hydrophobic drugs thereby reducing its systemic toxicity.
AIM: Glioblastoma multiforme is a devastating disease with no curative options due to the difficulty in achieving sufficient quantities of effective chemotherapies into the tumor past the blood-brain barrier. Micelles loaded with temozolomide (TMZ) were designed to increase the delivery of this drug into the brain. MATERIALS & METHODS: pH-responsive micelles composed of distearoyl phosphoethanolamine-PEG-2000-amine and N-palmitoyl homocysteine were surface-functionalized with PDGF peptide and Dylight 680 fluorophore. RESULTS & CONCLUSION: PDGF-micelles containing TMZ have specific uptake and increased killing in glial cells compared with untargeted micelles. In vivo studies demonstrated selective accumulation of PDGF-micelles containing TMZ in orthotopic gliomas implanted in mice. Targeted micelle-based drug carrier systems hold potential for delivery of a wide variety of hydrophobic drugs thereby reducing its systemic toxicity.
Authors: Yu Cheng; Joseph D Meyers; Richard S Agnes; Tennyson L Doane; Malcolm E Kenney; Ann-Marie Broome; Clemens Burda; James P Basilion Journal: Small Date: 2011-06-01 Impact factor: 13.281
Authors: Norased Nasongkla; Erik Bey; Jimin Ren; Hua Ai; Chalermchai Khemtong; Jagadeesh Setti Guthi; Shook-Fong Chin; A Dean Sherry; David A Boothman; Jinming Gao Journal: Nano Lett Date: 2006-11 Impact factor: 11.189
Authors: Michael James Clark; Nils Homer; Brian D O'Connor; Zugen Chen; Ascia Eskin; Hane Lee; Barry Merriman; Stanley F Nelson Journal: PLoS Genet Date: 2010-01-29 Impact factor: 5.917
Authors: Evgenii L Guryev; Anita S Smyshlyaeva; Natalia Y Shilyagina; Evgeniya A Sokolova; Samah Shanwar; Alexey B Kostyuk; Alexander V Lyubeshkin; Alexey A Schulga; Elena V Konovalova; Quan Lin; Indrajit Roy; Irina V Balalaeva; Sergey M Deyev; Andrei V Zvyagin Journal: Molecules Date: 2020-09-19 Impact factor: 4.411