Literature DB >> 17090068

Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.

Norased Nasongkla1, Erik Bey, Jimin Ren, Hua Ai, Chalermchai Khemtong, Jagadeesh Setti Guthi, Shook-Fong Chin, A Dean Sherry, David A Boothman, Jinming Gao.   

Abstract

We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.

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Year:  2006        PMID： 17090068     DOI： 10.1021/nl061412u

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  215 in total

1.  Nanoparticle design optimization for enhanced targeting: Monte Carlo simulations.

Authors:  Shihu Wang; Elena E Dormidontova
Journal:  Biomacromolecules       Date:  2010-07-12       Impact factor: 6.988

2.  Cisplatin@US-tube carbon nanocapsules for enhanced chemotherapeutic delivery.

Authors:  Adem Guven; Irene A Rusakova; Michael T Lewis; Lon J Wilson
Journal:  Biomaterials       Date:  2011-11-12       Impact factor: 12.479

Review 3.  Theranostic nanoplatforms for simultaneous cancer imaging and therapy: current approaches and future perspectives.

Authors:  Ki Young Choi; Gang Liu; Seulki Lee; Xiaoyuan Chen
Journal:  Nanoscale       Date:  2011-12-01       Impact factor: 7.790

Review 4.  Nanoparticle-based drug delivery: case studies for cancer and cardiovascular applications.

Authors:  Paul Galvin; Damien Thompson; Katie B Ryan; Anna McCarthy; Anne C Moore; Conor S Burke; Maya Dyson; Brian D Maccraith; Yurii K Gun'ko; Michelle T Byrne; Yuri Volkov; Chris Keely; Enda Keehan; Michael Howe; Conor Duffy; Ronan MacLoughlin
Journal:  Cell Mol Life Sci       Date:  2011-10-21       Impact factor: 9.261

Review 5.  Targeted polymeric therapeutic nanoparticles: design, development and clinical translation.

Authors:  Nazila Kamaly; Zeyu Xiao; Pedro M Valencia; Aleksandar F Radovic-Moreno; Omid C Farokhzad
Journal:  Chem Soc Rev       Date:  2012-03-05       Impact factor: 54.564

6.  Influence of Red Blood Cells on Nanoparticle Targeted Delivery in Microcirculation.

Authors:  Jifu Tan; Antony Thomas; Yaling Liu
Journal:  Soft Matter       Date:  2011-12-22       Impact factor: 3.679

Review 7.  Imaging and drug delivery using theranostic nanoparticles.

Authors:  Siti M Janib; Ara S Moses; J Andrew MacKay
Journal:  Adv Drug Deliv Rev       Date:  2010-08-13       Impact factor: 15.470

8.  A molecularly targeted theranostic probe for ovarian cancer.

Authors:  Wenxue Chen; Rizia Bardhan; Marc Bartels; Carlos Perez-Torres; Robia G Pautler; Naomi J Halas; Amit Joshi
Journal:  Mol Cancer Ther       Date:  2010-04-06       Impact factor: 6.261

9.  Nanotechnology in drug delivery and tissue engineering: from discovery to applications.

Authors:  Jinjun Shi; Alexander R Votruba; Omid C Farokhzad; Robert Langer
Journal:  Nano Lett       Date:  2010-09-08       Impact factor: 11.189

Review 10.  Polymeric Micelles: Recent Advancements in the Delivery of Anticancer Drugs.

Authors:  Avinash Gothwal; Iliyas Khan; Umesh Gupta
Journal:  Pharm Res       Date:  2015-09-17       Impact factor: 4.200
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