Literature DB >> 21630446

Addressing brain tumors with targeted gold nanoparticles: a new gold standard for hydrophobic drug delivery?

Yu Cheng1, Joseph D Meyers, Richard S Agnes, Tennyson L Doane, Malcolm E Kenney, Ann-Marie Broome, Clemens Burda, James P Basilion.   

Abstract

EGF-modified Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide-targeted Au NPs. Compared to the untargeted conjugates, EGF-Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard-to-reach cancers.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  brain tumors; gold nanoparticles; nanomedicine; photodynamic therapy; targeted delivery

Mesh：

Substances：

Year:  2011        PMID： 21630446      PMCID： PMC3837553          DOI： 10.1002/smll.201100628

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  31 in total

Review 1.  State of the art in the delivery of photosensitizers for photodynamic therapy.

Authors:  Yvette Niamien Konan; Robert Gurny; Eric Allémann
Journal:  J Photochem Photobiol B       Date:  2002-03       Impact factor: 6.252

Review 2.  An update on photodynamic therapy applications.

Authors:  Thomas J Dougherty
Journal:  J Clin Laser Med Surg       Date:  2002-02

Review 3.  Epidermal growth factor-related peptides and their receptors in human malignancies.

Authors:  D S Salomon; R Brandt; F Ciardiello; N Normanno
Journal:  Crit Rev Oncol Hematol       Date:  1995-07       Impact factor: 6.312

Review 4.  Drug and gene targeting to the brain with molecular Trojan horses.

Authors:  William M Pardridge
Journal:  Nat Rev Drug Discov       Date:  2002-02       Impact factor: 84.694

5.  Fluorescence resonance energy transfer reveals a binding site of a photosensitizer for photodynamic therapy.

Authors:  Rachel L Morris; Kashif Azizuddin; Minh Lam; Jeffrey Berlin; Anna-Liisa Nieminen; Malcolm E Kenney; Anna C S Samia; Clemens Burda; Nancy L Oleinick
Journal:  Cancer Res       Date:  2003-09-01       Impact factor: 12.701

6.  Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery.

Authors:  Giulio F Paciotti; Lonnie Myer; David Weinreich; Dan Goia; Nicolae Pavel; Richard E McLaughlin; Lawrence Tamarkin
Journal:  Drug Deliv       Date:  2004 May-Jun       Impact factor: 6.419

Review 7.  Photodynamic therapy of brain tumors.

Authors:  E A Popovic; A H Kaye; J S Hill
Journal:  J Clin Laser Med Surg       Date:  1996-10

Review 8.  Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications.

Authors:  Hiroshi Maeda; Jun Fang; Takao Inutsuka; Yasunori Kitamoto
Journal:  Int Immunopharmacol       Date:  2003-03       Impact factor: 4.932

Review 9.  Current perspectives on antiangiogenesis strategies in the treatment of malignant gliomas.

Authors:  Marnix Jansen; Philip C de Witt Hamer; Antonella N Witmer; Dirk Troost; Cornelis J F van Noorden
Journal:  Brain Res Brain Res Rev       Date:  2004-07

10.  A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Authors:  Y Matsumura; H Maeda
Journal:  Cancer Res       Date:  1986-12       Impact factor: 12.701
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  43 in total

Review 1.  Nanoparticle mediated non-covalent drug delivery.

Authors:  Tennyson Doane; Clemens Burda
Journal:  Adv Drug Deliv Rev       Date:  2012-06-01       Impact factor: 15.470

Review 2.  Combinatorial peptide libraries: mining for cell-binding peptides.

Authors:  Bethany Powell Gray; Kathlynn C Brown
Journal:  Chem Rev       Date:  2013-12-03       Impact factor: 60.622

Review 3.  Fluorescent-Guided Surgical Resection of Glioma with Targeted Molecular Imaging Agents: A Literature Review.

Authors:  Sonya E L Craig; James Wright; Andrew E Sloan; Susann M Brady-Kalnay
Journal:  World Neurosurg       Date:  2016-02-23       Impact factor: 2.104

4.  Precise targeting of cancer metastasis using multi-ligand nanoparticles incorporating four different ligands.

Authors:  P M Peiris; F He; G Covarrubias; S Raghunathan; O Turan; M Lorkowski; B Gnanasambandam; C Wu; W P Schiemann; E Karathanasis
Journal:  Nanoscale       Date:  2018-04-19       Impact factor: 7.790

5.  Vascular Targeting of a Gold Nanoparticle to Breast Cancer Metastasis.

Authors:  Pubudu M Peiris; Partha Deb; Elizabeth Doolittle; Gilad Doron; Amy Goldberg; Priya Govender; Shruti Shah; Swetha Rao; Sarah Carbone; Thomas Cotey; Meilyn Sylvestre; Sohaj Singh; William P Schiemann; Zhenghong Lee; Efstathios Karathanasis
Journal:  J Pharm Sci       Date:  2015-06-02       Impact factor: 3.534

6.  Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle.

Authors:  Pubudu M Peiris; Aaron Abramowski; James Mcginnity; Elizabeth Doolittle; Randall Toy; Ramamurthy Gopalakrishnan; Shruti Shah; Lisa Bauer; Ketan B Ghaghada; Christopher Hoimes; Susann M Brady-Kalnay; James P Basilion; Mark A Griswold; Efstathios Karathanasis
Journal:  Cancer Res       Date:  2015-01-27       Impact factor: 12.701

7.  Functional assays for specific targeting and delivery of RNA nanoparticles to brain tumor.

Authors:  Tae Jin Lee; Farzin Haque; Mario Vieweger; Ji Young Yoo; Balveen Kaur; Peixuan Guo; Carlo M Croce
Journal:  Methods Mol Biol       Date:  2015

Review 8.  Nanoparticles for imaging and treating brain cancer.

Authors:  Joseph D Meyers; Tennyson Doane; Clemens Burda; James P Basilion
Journal:  Nanomedicine (Lond)       Date:  2013-01       Impact factor: 5.307

Review 9.  Photodynamic nanomedicine in the treatment of solid tumors: perspectives and challenges.

Authors:  Alyssa Master; Megan Livingston; Anirban Sen Gupta
Journal:  J Control Release       Date:  2013-03-06       Impact factor: 9.776

10.  Imaging metastasis using an integrin-targeting chain-shaped nanoparticle.

Authors:  Pubudu M Peiris; Randall Toy; Elizabeth Doolittle; Jenna Pansky; Aaron Abramowski; Morgan Tam; Peter Vicente; Emily Tran; Elliott Hayden; Andrew Camann; Aaron Mayer; Bernadette O Erokwu; Zachary Berman; David Wilson; Harihara Baskaran; Chris A Flask; Ruth A Keri; Efstathios Karathanasis
Journal:  ACS Nano       Date:  2012-09-24       Impact factor: 15.881
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