Literature DB >> 26999495

Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet.

Qiushui Chen1, Stefanie Utech2, Dong Chen2, Radivoje Prodanovic3, Jin-Ming Lin4, David A Weitz2.   

Abstract

This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.

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Year:  2016        PMID： 26999495      PMCID： PMC4829496          DOI： 10.1039/c6lc00231e

Source DB:  PubMed          Journal:  Lab Chip        ISSN： 1473-0189            Impact factor:   6.799


  34 in total

1.  Engineering cell-compatible paper chips for cell culturing, drug screening, and mass spectrometric sensing.

Authors:  Qiushui Chen; Ziyi He; Wu Liu; Xuexia Lin; Jing Wu; Haifang Li; Jin-Ming Lin
Journal:  Adv Healthc Mater       Date:  2015-09-17       Impact factor: 9.933

Review 2.  Cells on chips.

Authors:  Jamil El-Ali; Peter K Sorger; Klavs F Jensen
Journal:  Nature       Date:  2006-07-27       Impact factor: 49.962

3.  Concave microwell based size-controllable hepatosphere as a three-dimensional liver tissue model.

Authors:  Sau Fung Wong; Da Yoon No; Yoon Young Choi; Dong Sik Kim; Bong Geun Chung; Sang-Hoon Lee
Journal:  Biomaterials       Date:  2011-08-02       Impact factor: 12.479

4.  Molding cell beads for rapid construction of macroscopic 3D tissue architecture.

Authors:  Yukiko T Matsunaga; Yuya Morimoto; Shoji Takeuchi
Journal:  Adv Mater       Date:  2011-03-01       Impact factor: 30.849

5.  Microfluidic Generation of Monodisperse, Structurally Homogeneous Alginate Microgels for Cell Encapsulation and 3D Cell Culture.

Authors:  Stefanie Utech; Radivoje Prodanovic; Angelo S Mao; Raluca Ostafe; David J Mooney; David A Weitz
Journal:  Adv Healthc Mater       Date:  2015-06-03       Impact factor: 9.933

6.  3D bioprinting of tissues and organs.

Authors:  Sean V Murphy; Anthony Atala
Journal:  Nat Biotechnol       Date:  2014-08       Impact factor: 54.908

Review 7.  Cooperation of liver cells in health and disease.

Authors:  Z Kmieć
Journal:  Adv Anat Embryol Cell Biol       Date:  2001       Impact factor: 1.231

Review 8.  Organs-on-chips at the frontiers of drug discovery.

Authors:  Eric W Esch; Anthony Bahinski; Dongeun Huh
Journal:  Nat Rev Drug Discov       Date:  2015-03-20       Impact factor: 84.694

9.  Controlled synthesis of cell-laden microgels by radical-free gelation in droplet microfluidics.

Authors:  Torsten Rossow; John A Heyman; Allen J Ehrlicher; Arne Langhoff; David A Weitz; Rainer Haag; Sebastian Seiffert
Journal:  J Am Chem Soc       Date:  2012-03-01       Impact factor: 15.419

10.  Rapid 3D Extrusion of Synthetic Tumor Microenvironments.

Authors:  Joshua M Grolman; Douglas Zhang; Andrew M Smith; Jeffrey S Moore; Kristopher A Kilian
Journal:  Adv Mater       Date:  2015-08-18       Impact factor: 30.849
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  36 in total

Review 1.  Generation and manipulation of hydrogel microcapsules by droplet-based microfluidics for mammalian cell culture.

Authors:  Haishui Huang; Yin Yu; Yong Hu; Xiaoming He; O Berk Usta; Martin L Yarmush
Journal:  Lab Chip       Date:  2017-05-31       Impact factor: 6.799

2.  One step fabrication of hydrogel microcapsules with hollow core for assembly and cultivation of hepatocyte spheroids.

Authors:  Christian Siltanen; Michalitsa Diakatou; Jeremy Lowen; Amranul Haque; Ali Rahimian; Gulnaz Stybayeva; Alexander Revzin
Journal:  Acta Biomater       Date:  2017-01-06       Impact factor: 8.947

3.  Hydrogel microparticles for biomedical applications.

Authors:  Andrew C Daly; Lindsay Riley; Tatiana Segura; Jason A Burdick
Journal:  Nat Rev Mater       Date:  2019-11-07       Impact factor: 66.308

Review 4.  Stem cell transplantation for treating liver diseases: progress and remaining challenges.

Authors:  Shanshan Li; Yanzhen Bi; Zhongping Duan; Yongkai Chang; Feng Hong; Yu Chen
Journal:  Am J Transl Res       Date:  2021-05-15       Impact factor: 4.060

5.  Dynamic Complex Emulsions as Amplifiers for On-Chip Photonic Cavity-Enhanced Resonators.

Authors:  Suchol Savagatrup; Danhao Ma; Huikai Zhong; Kent S Harvey; Lionel C Kimerling; Anuradha M Agarwal; Timothy M Swager
Journal:  ACS Sens       Date:  2020-05-22       Impact factor: 7.711

Review 6.  Cell-laden microfluidic microgels for tissue regeneration.

Authors:  Weiqian Jiang; Mingqiang Li; Zaozao Chen; Kam W Leong
Journal:  Lab Chip       Date:  2016-11-15       Impact factor: 6.799

Review 7.  Recent advances in microfluidics for drug screening.

Authors:  Jiahui Sun; Antony R Warden; Xianting Ding
Journal:  Biomicrofluidics       Date:  2019-11-18       Impact factor: 2.800

8.  Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in Three-Dimensional Models.

Authors:  David A Kukla; Alexandra L Crampton; David K Wood; Salman R Khetani
Journal:  Gene Expr       Date:  2020-04-14

9.  Recent Advances in Design of Fluorescence-Based Assays for High-Throughput Screening.

Authors:  Xiaoni Fang; Yongzan Zheng; Yaokai Duan; Yang Liu; Wenwan Zhong
Journal:  Anal Chem       Date:  2018-12-10       Impact factor: 6.986

10.  Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis.

Authors:  Ryan E Feaver; Banumathi K Cole; Mark J Lawson; Stephen A Hoang; Svetlana Marukian; Brett R Blackman; Robert A Figler; Arun J Sanyal; Brian R Wamhoff; Ajit Dash
Journal:  JCI Insight       Date:  2016-12-08
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