Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes.

Literature DB >> 26998692

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes.

James Dooley^1,2, Lei Tian^1,2, Susann Schonefeldt^1,2, Viviane Delghingaro-Augusto³, Josselyn E Garcia-Perez^1,2, Emanuela Pasciuto^1,2, Daniele Di Marino⁴, Edward J Carr⁵, Nikolay Oskolkov⁶, Valeriya Lyssenko^6,7, Dean Franckaert^1,2, Vasiliki Lagou^1,2,8, Lut Overbergh⁹, Jonathan Vandenbussche^10,11, Joke Allemeersch¹², Genevieve Chabot-Roy^13,14, Jane E Dahlstrom^3,15, D Ross Laybutt¹⁶, Nikolai Petrovsky¹⁷, Luis Socha¹⁸, Kris Gevaert^10,11, Anton M Jetten¹⁹, Diether Lambrechts^20,21, Michelle A Linterman⁵, Chris C Goodnow¹⁶, Christopher J Nolan^3,22, Sylvie Lesage^13,14, Susan M Schlenner^1,2, Adrian Liston^1,2.

Abstract

Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic variation in Xrcc4 and Glis3 alters the response of NOD beta cells to unfolded protein stress, enhancing the apoptotic and senescent fates. The same transcriptional relationships were observed in human islets, demonstrating the role of beta cell fragility in genetic predisposition to diabetes.

Entities: Chemical

Mesh：

Substances：

Year: 2016 PMID： 26998692 PMCID： PMC5584070 DOI： 10.1038/ng.3531

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

71 in total

1. A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations.

Authors: Yong Duan; Chun Wu; Shibasish Chowdhury; Mathew C Lee; Guoming Xiong; Wei Zhang; Rong Yang; Piotr Cieplak; Ray Luo; Taisung Lee; James Caldwell; Junmei Wang; Peter Kollman
Journal: J Comput Chem Date: 2003-12 Impact factor: 3.376

2. Langevin equation with colored noise for constant-temperature molecular dynamics simulations.

Authors: Michele Ceriotti; Giovanni Bussi; Michele Parrinello
Journal: Phys Rev Lett Date: 2009-01-14 Impact factor: 9.161

3. ms_lims, a simple yet powerful open source laboratory information management system for MS-driven proteomics.

Authors: Kenny Helsens; Niklaas Colaert; Harald Barsnes; Thilo Muth; Kristian Flikka; An Staes; Evy Timmerman; Steffi Wortelkamp; Albert Sickmann; Joël Vandekerckhove; Kris Gevaert; Lennart Martens
Journal: Proteomics Date: 2010-03 Impact factor: 3.984

Review 4. Endoplasmic reticulum stress and type 2 diabetes.

Authors: Sung Hoon Back; Randal J Kaufman
Journal: Annu Rev Biochem Date: 2012-03-23 Impact factor: 23.643

5. Ubx2 links the Cdc48 complex to ER-associated protein degradation.

Authors: Oliver Neuber; Ernst Jarosch; Corinna Volkwein; Jan Walter; Thomas Sommer
Journal: Nat Cell Biol Date: 2005-09-18 Impact factor: 28.824

6. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Authors: Aravind Subramanian; Pablo Tamayo; Vamsi K Mootha; Sayan Mukherjee; Benjamin L Ebert; Michael A Gillette; Amanda Paulovich; Scott L Pomeroy; Todd R Golub; Eric S Lander; Jill P Mesirov
Journal: Proc Natl Acad Sci U S A Date: 2005-09-30 Impact factor: 11.205

7. Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.

Authors: Valérie Senée; Claude Chelala; Sabine Duchatelet; Daorong Feng; Hervé Blanc; Jack-Christophe Cossec; Céline Charon; Marc Nicolino; Pascal Boileau; Douglas R Cavener; Pierre Bougnères; Doris Taha; Cécile Julier
Journal: Nat Genet Date: 2006-05-21 Impact factor: 38.330

8. Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death.

Authors: Andria Apostolou; Yuxian Shen; Yan Liang; Jun Luo; Shengyun Fang
Journal: Exp Cell Res Date: 2008-05-13 Impact factor: 3.905

9. Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells.

Authors: Emma L Davenport; Hannah E Moore; Alan S Dunlop; Swee Y Sharp; Paul Workman; Gareth J Morgan; Faith E Davies
Journal: Blood Date: 2007-05-24 Impact factor: 22.113

10. GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.

Authors: Tatiane C Nogueira; Flavia M Paula; Olatz Villate; Maikel L Colli; Rodrigo F Moura; Daniel A Cunha; Lorella Marselli; Piero Marchetti; Miriam Cnop; Cécile Julier; Decio L Eizirik
Journal: PLoS Genet Date: 2013-05-30 Impact factor: 5.917

52 in total

Review 1. Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles.

Authors: Yeawon Kim; Sun-Ji Park; Ying Maggie Chen
Journal: Transl Res Date: 2017-06-29 Impact factor: 7.012

Review 2. Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer.

Authors: Phil A Hart; Melena D Bellin; Dana K Andersen; David Bradley; Zobeida Cruz-Monserrate; Christopher E Forsmark; Mark O Goodarzi; Aida Habtezion; Murray Korc; Yogish C Kudva; Stephen J Pandol; Dhiraj Yadav; Suresh T Chari
Journal: Lancet Gastroenterol Hepatol Date: 2016-10-12

3. Genetic Modifiers of Cystic Fibrosis-Related Diabetes Have Extensive Overlap With Type 2 Diabetes and Related Traits.

Authors: Melis A Aksit; Rhonda G Pace; Briana Vecchio-Pagán; Hua Ling; Johanna M Rommens; Pierre-Yves Boelle; Loic Guillot; Karen S Raraigh; Elizabeth Pugh; Peng Zhang; Lisa J Strug; Mitch L Drumm; Michael R Knowles; Garry R Cutting; Harriet Corvol; Scott M Blackman
Journal: J Clin Endocrinol Metab Date: 2020-05-01 Impact factor: 5.958

Review 4. New Evidence of Exocrine Pancreatopathy in Pre-symptomatic and Symptomatic Type 1 Diabetes.

Authors: Federica Vecchio; Gloria Messina; Anna Giovenzana; Alessandra Petrelli
Journal: Curr Diab Rep Date: 2019-08-31 Impact factor: 4.810

Review 5. The genomic landscape of African populations in health and disease.

Authors: Charles N Rotimi; Amy R Bentley; Ayo P Doumatey; Guanjie Chen; Daniel Shriner; Adebowale Adeyemo
Journal: Hum Mol Genet Date: 2017-10-01 Impact factor: 6.150

6. Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).

Authors: Daniel A Cunha; Monia Cito; Fabio Arturo Grieco; Cristina Cosentino; Tatiana Danilova; Laurence Ladrière; Maria Lindahl; Andrii Domanskyi; Marco Bugliani; Piero Marchetti; Décio L Eizirik; Miriam Cnop
Journal: J Biol Chem Date: 2017-07-11 Impact factor: 5.157

7. Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11.

Authors: Tomoki Maegawa; Yuki Miyasaka; Misato Kobayashi; Naru Babaya; Hiroshi Ikegami; Fumihiko Horio; Masahide Takahashi; Tamio Ohno
Journal: Mamm Genome Date: 2018-03-09 Impact factor: 2.957